Gastroenterology and Hepatology from Bed to Bench

Abstract

ABSTRACT

Background and Purposes: Gastrointestinal cancers including stomach adenocarcinoma are very prevalent and one the main causes of death due to cancer. Mazandaran has a high mortality rate of stomach adenocarcinoma. This study was proposed for estimation of survival time in patients with stomach adenocarcinoma.

Materials and Methods: The study was historical cohort. The samples were the patients with stomach adenocarcinoma referred to Tooba clinic among 3 years (2007-2010). A parametric model was fitted on data. Kaplan Mayer and life table method were used for estimation of survival probability.  The effects of covariates on survival time were assessed by Cox Regression model.

Results: 68.3% of the patients were men and 31.7% were women. The mean of patients' age was 64 years. 48.4% of patients were in the most advanced stage i.e.: stage 4. The more than 2 years survival probability of patients was calculated 27.7% by using Kaplan Mayer method. The stage, metastasis, surgery, and age were the variables which affect the survival probability of patients, by using Cox hazard proportional model.

Conclusion:  The survival time of our patients is much lower than the developed countries which are related to latency in diagnosis and therapeutic limitations.

Key words: stomach adenocarcinoma, parametric model, life table, Cox hazard proportional model.

1) Corresponded Author  ,Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran

2) Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran

3) Department of Internal Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

4)Tehran university,Tehran ,Iran

5) Department of Occupational health, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran