Evaluation of salivary beta-2 microglobulin as HBV proliferation marker in HBS Ag+, HBV DNA PCR+ and HBV DNA PCR- subjects
Gastroenterology and Hepatology from Bed to Bench,
Vol. 6 No. Supplement 1 (2013),
5 October 2013
Page Gastroenterol Hepatol Bed Bench 2013;6(Suppl.1):S105-S111
Aim: The aim of this study was to determine the concentration of salivary ?2M as a marker of viral proliferation in HBS Ag+, HBV DNA PCR+ and Hbs Ag+ and HBV DNA PCR- subjects.
Background: Beta-2 microglobulin (?2M) is responsible for transmission of viral antigens such as Hepatitis B (HBV) on the surface of liver cells as part of an HLA complex.
Patients and methods: In this case control study, 25 PCR+ and 2 PCR- patients were included. 5 mL of the saliva sample was obtained from all patients and salivary ?2M level was measured using nephelometer. The data was evaluated by the descriptive, chi square and t tests.
Results: 72% of the PCR+ patients received medications and in contrast, 85.7% of the patients with PCR- did not take any medication (P<0.001). The average salivary concentration ofBeta-2 microglobulin in the PCR+ group (5.28 ± 5.45 mg/deciliter) was more than PCR- group (1.51±0.77) and this difference was statistically significant (P=0.003).
Conclusion: the salivary B2Mlevel can be used as a marker of viral proliferation in patients with hepatitis B.
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