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  3. Vol. 6 No. Supplement 1 (2013): Supplement 1
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Vol. 6 No. Supplement 1 (2013)

October 2013

Functionalization of MWNT-COOH by one-step reaction with (3-oxoindolin-2-ylidene) urea and in vitro antitumor study on gastric cancer

  • Saeed Heidari- Keshel
  • Mahdieh Entezari
  • Mostafa Rezaei-Tavirani
  • Maryam Ebrahimi
  • Majid Rezaei-Tavirani

Gastroenterology and Hepatology from Bed to Bench, Vol. 6 No. Supplement 1 (2013), 5 October 2013 , Page Gastroenterol Hepatol Bed Bench 2013;6(Suppl.1):S39-S44
https://doi.org/10.22037/ghfbb.v6i0.471 Published: 2013-10-09

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Abstract

Aim: In this study, we was tried to prepare a nano compound with a new way in functionalization as anti gastric cancer candidate.

Background: Functionalization of nanotubes is a useful route for modification of their biologic properties. (3-oxoindolin-2-ylidene) urea is a chemical compound that made of isatin and urea that can be useful in cancer study.

Patients and methods: MWNT-COOH was functionalized by this compound with one-step reaction that is a new class in modification. Product has been investigated by FT-IR, Raman and SEM. Anti cancer investigation with human gastric cells and MTT assay test for measurement of viable cell numbers were also performed.

Results: The two bands at around 2800–2900 cm-1 which are seen in functionalized product are attributed to the CH stretching of MWNT–COOH defects.

Conclusion: Cellular results demonstrated that the functionalized nano-tube is a more toxic agent compared to other samples for cancer cells and can be used as a candidate material for chemotherapy.

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How to Cite

Heidari- Keshel, S., Entezari, M., Rezaei-Tavirani, M., Ebrahimi, M., & Rezaei-Tavirani, M. (2013). Functionalization of MWNT-COOH by one-step reaction with (3-oxoindolin-2-ylidene) urea and in vitro antitumor study on gastric cancer. Gastroenterology and Hepatology from Bed to Bench, 6(Supplement 1), Gastroenterol Hepatol Bed Bench 2013;6(Suppl.1):S39–S44. https://doi.org/10.22037/ghfbb.v6i0.471
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Print ISSN: 2008-2258
Online ISSN: 2008-4234

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