Functionalization of MWNT-COOH by one-step reaction with (3-oxoindolin-2-ylidene) urea and in vitro antitumor study on gastric cancer
Gastroenterology and Hepatology from Bed to Bench,
Vol. 6 No. Supplement 1 (2013),
5 October 2013
,
Page Gastroenterol Hepatol Bed Bench 2013;6(Suppl.1):S39-S44
https://doi.org/10.22037/ghfbb.v6i0.471
Abstract
Aim: In this study, we was tried to prepare a nano compound with a new way in functionalization as anti gastric cancer candidate.
Background: Functionalization of nanotubes is a useful route for modification of their biologic properties. (3-oxoindolin-2-ylidene) urea is a chemical compound that made of isatin and urea that can be useful in cancer study.
Patients and methods: MWNT-COOH was functionalized by this compound with one-step reaction that is a new class in modification. Product has been investigated by FT-IR, Raman and SEM. Anti cancer investigation with human gastric cells and MTT assay test for measurement of viable cell numbers were also performed.
Results: The two bands at around 2800–2900 cm-1 which are seen in functionalized product are attributed to the CH stretching of MWNT–COOH defects.
Conclusion: Cellular results demonstrated that the functionalized nano-tube is a more toxic agent compared to other samples for cancer cells and can be used as a candidate material for chemotherapy.
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