Evaluation of the benefit of addition of clidinium C to a Helicobacter pylori eradication regimen
Gastroenterology and Hepatology from Bed to Bench,
Vol. 6 No. 3 (2013),
9 June 2013
,
Page Gastroenterol Hepatol Bed Bench 2013;6(3):141-145
https://doi.org/10.22037/ghfbb.v6i3.386
Abstract
Aim: This study aimed to evaluate the success of H.pylori eradication therapy in patients with dyspepsia by therapeutics regimes with and without clidinium C.
Background: Helicobacter pylori infections are reported in all parts of the world. Appropriate antibiotic therapy can treat infection. The ideal treatment regimen has not been specified.
Patients and methods: In a randomized, double blind clinical trials study, 250 patients with dyspepsia were enrolled. All patients were treated by Omeprazole, Metronidazole, Amoxicillin and Bismuth (OMAB) for two weeks. One tablet clidinium C before each meal was added to this regimen in the intervention group (A). Urea Breath Test (UBT) was carried out after 8-12 weeks after treatment for evaluation of H.pylori eradication.
Results: 132 patients in the intervention group (A) and 118 patients in the control group (B) were enrolled to the study. The rate of eradication in group A was significantly higher than group B (62.1% vs. 50%, p=0.04).
Conclusion: The results supported the effect of clidinium C for increasing of helicobacter pylori eradication, but further studies need to be performed.
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