ISSN: 2008-2258
Vol 16, No 1 (2023): Winter
Granulocyte Colony-Stimulating Factor Does Not Improve Mortality in Severe Alcoholic Hepatitis: A Single-Center Experience from the United States
Gastroenterology and Hepatology from Bed to Bench,
,
https://doi.org/10.22037/ghfbb.v16i1.2639
Abstract
Background: Severe alcoholic hepatitis is a disease with high mortality and poor medical options. Few studies from India have reported survival benefit with granulocyte colony-stimulating factor (GCSF), though real-world data and data outside of Asia is lacking.
Materials and Methods: We performed a single-center retrospective study of consecutive patients admitted to a tertiary care, liver transplant center with severe alcoholic hepatitis from May 2015 to February 2019. Patients receiving GCSF (5μg/kg subcutaneously every 12 hours for 5 consecutive days) (n=12) were compared to patients receiving standard of care (n=42).
Results: Thirty-day, 90-day and 1-year mortality rates was similar between groups (25% vs. 17%, p=0.58; 41% vs 29%, p=0.30; 41% vs 47%, p=0.44, respectively). There was no difference in liver transplant listing and orthotopic transplantation between groups.
Conclusions: In this real-world, United States-based study, GCSF does not improved survival in patient with several alcoholic hepatitis compared to standard of care.
- alcoholic hepatitis; granulocyte colony-stimulating factor; liver failure
How to Cite
References
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