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  3. Vol 16, No 1 (2023): Winter
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ISSN: 2008-2258

Vol 16, No 1 (2023): Winter

Granulocyte Colony-Stimulating Factor Does Not Improve Mortality in Severe Alcoholic Hepatitis: A Single-Center Experience from the United States

  • Jonathan Nahas
  • Clara Tow
  • Kristina R. Chacko
  • Tehseen Haider
  • Hatef Massoumi

Gastroenterology and Hepatology from Bed to Bench, ,
https://doi.org/10.22037/ghfbb.v16i1.2639 Published 31 December 2022

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Abstract

Background: Severe alcoholic hepatitis is a disease with high mortality and poor medical options. Few studies from India have reported survival benefit with granulocyte colony-stimulating factor (GCSF), though real-world data and data outside of Asia is lacking.


Materials and Methods: We performed a single-center retrospective study of consecutive patients admitted to a tertiary care, liver transplant center with severe alcoholic hepatitis from May 2015 to February 2019. Patients receiving GCSF (5μg/kg subcutaneously every 12 hours for 5 consecutive days) (n=12) were compared to patients receiving standard of care (n=42).


Results: Thirty-day, 90-day and 1-year mortality rates was similar between groups (25% vs. 17%, p=0.58; 41% vs 29%, p=0.30; 41% vs 47%, p=0.44, respectively). There was no difference in liver transplant listing and orthotopic transplantation between groups.


Conclusions: In this real-world, United States-based study, GCSF does not improved survival in patient with several alcoholic hepatitis compared to standard of care.

Keywords:
  • alcoholic hepatitis; granulocyte colony-stimulating factor; liver failure

How to Cite

Nahas, J., Tow, C., R. Chacko, K., Haider, T., & Massoumi, H. (2022). Granulocyte Colony-Stimulating Factor Does Not Improve Mortality in Severe Alcoholic Hepatitis: A Single-Center Experience from the United States. Gastroenterology and Hepatology from Bed to Bench, 16(1). https://doi.org/10.22037/ghfbb.v16i1.2639
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References

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2. Mathurin P, Moreno C, Samuel D, Dumortier J, Salleron J, Durand F, et al. Early liver transplantation for severe alcoholic hepatitis. NEJM 2011;365(19):1790-800.
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5. Singh V, Sharma AK, Narasimhan RL, Bhalla A, Sharma N, Sharma R. Granulocyte colony-stimulating factor in severe alcoholic hepatitis: a randomized pilot study. Am J Gastroenterol 2014;109(9):1417-22.
6. Singh V, Keisham A, Bhalla A, Sharma N, Agarwal R, Sharma R, et al. Efficacy of granulocyte colony-stimulating factor and N-acetylcysteine therapies in patients with severe alcoholic hepatitis. Clin Gastroenterol Hepatol 2018; 16(10): 1650-56.
7. Shasthry SM, Sharma MK, Shasthry V, Pande A, Sarin SK. Efficacy of granulocyte colony-stimulating factor in the management of steroid-nonresponsive severe alcoholic hepatitis: a double-blind randomized control trial. Hepatology 2019; 70(3): 802-11.
8. Rathi S, Hussaini T, Yoshida EM. Granulocyte colony stimulating factor: a potential therapeutic rescue in severe alcoholic hepatitis and decompensated cirrhosis. Ann Hepatol 2021;20: 100211.
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GHFBB journal is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0).

Print ISSN: 2008-2258
Online ISSN: 2008-4234

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