Comparison the potency of Nortriptyline and Mirtazapine on gastrointestinal symptoms, the level of anxiety and depression in patients with functional dyspepsia Comparison the Impact of Nortriptyline and Mirtazapine on Functional Dyspepsia
Gastroenterology and Hepatology from Bed to Bench,
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https://doi.org/10.22037/ghfbb.v16i1.2513
Abstract
Background: Functional dyspepsia usually accompanies other psychosocial disorders. According to previous studies, among these disorders, anxiety, and depression have the most correlation. In the current clinical trial study, we compared the potency of mirtazapine and nortriptyline in FD-patients who presented anxiety or depression.
Study design: This randomized clinical trial has been organized in Taleghani hospital (Tehran, Iran). In two parallel groups, 42 patients (22 patients in Mirtazapine 7.5 mg/daily arm and 20 in the Nortriptyline 25 mg/day group) were treated for 12 weeks. The patients with Positive history of antidepressant therapy, organic diseases, alcohol abuse, pregnancy, major psychiatric disorders were excluded. They were examined by three types of questionnaires (Nepean questionnaire, Hamilton questionnaires) three times: 1) before the onset of treatment, 2) during the treatment, and 3) at the end.
Results: Based on Gastrointestinal (GI) manifestation, Mirtazapine in comparison to Nortriptyline could significantly suppress the signs and symptoms, including epigastric pain (P=0.02), belching (P=0.004), and bloating (P=0.01). Although The results revealed that the Mirtazapine with the lower mean depression score of the Hamilton questionnaire at the end of the treatment led to a better result compared to Nortriptyline (P=0.002), but, there are no significant differences between the effects of these drugs on the anxiety scale of patients (P = 0.091).
Conclusion: Mirtazapine is more effective for GI symptoms related to gastric emptying. Whereas, Mirtazapine revealed better outcomes in FD-patients with depression, but according to the level of anxiety, Mirtazapine showed no better outcome in comparison with Nortriptyline.
- Functional Dyspepsia (FD)
- Depression
- Anxiety
- Nortriptyline
- Mirtazapine
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References
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