Introducing AKT1 as a Critical Common Dysregulated Proteins in Esophageal, Gastric, and Intestinal Cancers
Gastroenterology and Hepatology from Bed to Bench,
Aim: The aim of this study is determining the common dysregulated proteins between esophageal, gastric, and intestinal cancers.
Background: There are several documents about role of AKT1 in promotion of esophageal, gastric, and intestinal cancers.
Methods: Number of 100 proteins related to each of esophageal, gastric, and intestinal cancers were retrieved from STRING database and interacted by Cytoscape software v 3.2.7. 2 to create the correlated interactomes. Results of network analysis and action map assessment were used to determine the common critical proteins between the three studied cancers.
Results: Among 42 common dysregulated proteins 36 individuals were selected via network analysis which were screened via action map assessment and 18 ones were introduced as the important common proteins. Finally, AKT1 was candidate as the crucial dysregulated proteins common the three analyzed diseases.
Conclusions: finding indicates that AKT1 is a suitable candidate to be evaluate in patients as a pre diagnostic tool to reduce endoscopy and colonoscopy rate.
- Esophageal cancer- gastric cancer– intestinal cancer – Network analysis- AKT1
How to Cite
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