Introducing AKT1 as a Critical Common Dysregulated Proteins in Esophageal, Gastric, and Intestinal Cancers
Gastroenterology and Hepatology from Bed to Bench,
Vol. 15 No. 1 (2022),
30 January 2022
https://doi.org/10.22037/ghfbb.vi.2510
Abstract
Aim: The aim of this study is determining the common dysregulated proteins between esophageal, gastric, and intestinal cancers.
Background: There are several documents about role of AKT1 in promotion of esophageal, gastric, and intestinal cancers.
Methods: Number of 100 proteins related to each of esophageal, gastric, and intestinal cancers were retrieved from STRING database and interacted by Cytoscape software v 3.2.7. 2 to create the correlated interactomes. Results of network analysis and action map assessment were used to determine the common critical proteins between the three studied cancers.
Results: Among 42 common dysregulated proteins 36 individuals were selected via network analysis which were screened via action map assessment and 18 ones were introduced as the important common proteins. Finally, AKT1 was candidate as the crucial dysregulated proteins common the three analyzed diseases.
Conclusions: finding indicates that AKT1 is a suitable candidate to be evaluate in patients as a pre diagnostic tool to reduce endoscopy and colonoscopy rate.
- Esophageal cancer- gastric cancer– intestinal cancer – Network analysis- AKT1
How to Cite
References
2. Ahmed M. Colon cancer: a clinician’s perspective in 2019. Gastroenterology research. 2020;13(1):1.
3. Barani M, Sabir F, Rahdar A, Arshad R, Kyzas GZ. Nanotreatment and nanodiagnosis of prostate cancer: recent updates. Nanomaterials. 2020;10(9):1696.
4. Dubey P, Thakur V, Chattopadhyay M. Role of minerals and trace elements in diabetes and insulin resistance. Nutrients. 2020;12(6):1864.
5. Rezaei-Tavirani M, Nejad MR, Arjmand B, Tavirani SR, Razzaghi M, Mansouri V. Fibrinogen Dysregulation is a Prominent Process in Fatal Conditions of COVID-19 Infection; a Proteomic Analysis. Archives of Academic Emergency Medicine. 2021;9(1).
6. Rezaei Tavirani M, Arjmand B, Razzaghi M, Ahmadzadeh A. 50S Ribosomal proteins family is the main target of cinnamon extract: a network analysis. Research Journal of Pharmacognosy. 2021;8(2):63-8.
7. Hu G, Wu Z, Uversky VN, Kurgan L. Functional analysis of human hub proteins and their interactors involved in the intrinsic disorder-enriched interactions. International journal of molecular sciences. 2017;18(12):2761.
8. Yang S, Senapati P, Wang D, Bauch CT, Fountoulakis K. Targeted pandemic containment through identifying local contact network bottlenecks. PLoS computational biology. 2021;17(8):e1009351.
9. Salavati C, Abdollahpouri A, Manbari Z. Ranking nodes in complex networks based on local structure and improving closeness centrality. Neurocomputing. 2019;336:36-45.
10. Rezaei-Tavirani M, Arjmand B, Khodadost M, Sherafat SJ, Ahmadi N, Moghadam MH, et al. The Principal Role of Several Members of HLA and IRF Genes in Prevention of Oral Mucositis After Chemoradiotherapy. Journal of Lasers in Medical Sciences. 2021;12:e65-e.
11. Szklarczyk D, Gable AL, Nastou KC, Lyon D, Kirsch R, Pyysalo S, et al. The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets. Nucleic acids research. 2021;49(D1):D605-D12.
12. Doncheva NT, Morris JH, Gorodkin J, Jensen LJ. Cytoscape StringApp: network analysis and visualization of proteomics data. Journal of proteome research. 2018;18(2):623-32.
13. Barra WF, Moreira FC, Cruz AMP, Khayat AS, Calcagno DQ, Dos Santos NPC, et al. GEJ cancers: gastric or esophageal tumors? searching for the answer according to molecular identity. Oncotarget. 2017;8(61):104286.
14. Hu B, El Hajj N, Sittler S, Lammert N, Barnes R, Meloni-Ehrig A. Gastric cancer: Classification, histology and application of molecular pathology. Journal of gastrointestinal oncology. 2012;3(3):251.
15. Choi KS, Suh M. Screening for gastric cancer: the usefulness of endoscopy. Clinical endoscopy. 2014;47(6):490.
16. Evans JA, Early DS, Chandraskhara V, Chathadi KV, Fanelli RD, Fisher DA, et al. The role of endoscopy in the assessment and treatment of esophageal cancer. Gastrointestinal endoscopy. 2013;77(3):328-34.
17. Forbes N, Hilsden RJ, Martel M, Ruan Y, Dube C, Rostom A, et al. Association between time to colonoscopy after positive fecal testing and colorectal cancer outcomes: a systematic review. Clinical Gastroenterology and Hepatology. 2021;19(7):1344-54. e8.
18. Wang L-L, Zhang L, Cui X-F. Downregulation of long noncoding RNA LINC01419 inhibits cell migration, invasion, and tumor growth and promotes autophagy via inactivation of the PI3K/Akt1/mTOR pathway in gastric cancer. Therapeutic advances in medical oncology. 2019;11:1758835919874651.
19. Carpten JD, Faber AL, Horn C, Donoho GP, Briggs SL, Robbins CM, et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature. 2007;448(7152):439-44.
20. Zhang X, Wang S, Wang H, Cao J, Huang X, Chen Z, et al. Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway. Molecular cancer. 2019;18(1):1-24.
21. Pan C, Liu Q, Wu X. HIF1α/miR-520a-3p/AKT1/mTOR feedback promotes the proliferation and glycolysis of gastric cancer cells. Cancer management and research. 2019;11:10145.
22. Li W, Hou J-Z, Niu J, Xi Z-Q, Ma C, Sun H, et al. Akt1 inhibition promotes breast cancer metastasis through EGFR-mediated β-catenin nuclear accumulation. Cell Communication and Signaling. 2018;16(1):1-13.
23. Xu G, Wang H, Yuan D, Yao J, Meng L, Li K, et al. RUNX1-activated upregulation of lncRNA RNCR3 promotes cell proliferation, invasion, and suppresses apoptosis in colorectal cancer via miR-1301-3p/AKT1 axis in vitro and in vivo. Clinical and Translational Oncology. 2020;22(10):1762-77.
24. Liu X, Song M, Wang P, Zhao R, Chen H, Zhang M, et al. Targeted therapy of the AKT kinase inhibits esophageal squamous cell carcinoma growth in vitro and in vivo. International journal of cancer. 2019;145(4):1007-19.
25. Rezaei-Tavirani M, Rezaei-Tavirani S, Mansouri V, Rostami-Nejad M, Rezaei-Tavirani M. Protein-protein interaction network analysis for a biomarker panel related to human esophageal adenocarcinoma. Asian Pacific journal of cancer prevention: APJCP. 2017;18(12):3357.
26. Wei W-t, Wang L, Liang J-x, Wang J-f, Li Q, Zeng J. LncRNA EIF3J-AS1 enhanced esophageal cancer invasion via regulating AKT1 expression through sponging miR-373-3p. Scientific Reports. 2020;10(1):1-9.
27. Liu T-t, Liu X-s, Zhang M, Liu X-n, Zhu F-x, Zhu F-m, et al. Cartilage oligomeric matrix protein is a prognostic factor and biomarker of colon cancer and promotes cell proliferation by activating the Akt pathway. Journal of cancer research and clinical oncology. 2018;144(6):1049-63.
28. Wei W-T, Nian X-X, Wang S-Y, Jiao H-L, Wang Y-X, Xiao Z-Y, et al. miR-422a inhibits cell proliferation in colorectal cancer by targeting AKT1 and MAPK1. Cancer cell international. 2017;17(1):1-12.
29. Jia L, Luo S, Ren X, Li Y, Hu J, Liu B, et al. miR-182 and miR-135b mediate the tumorigenesis and invasiveness of colorectal cancer cells via targeting ST6GALNAC2 and PI3K/AKT pathway. Digestive diseases and sciences. 2017;62(12):3447-59.
- Abstract Viewed: 23 times
- pdf Downloaded: 23 times