ISSN: 2008-2258
Vol 15, No 3 (2022): Summer
Prevalence of enteric adenovirus and co-infection with rotavirus in children under 15 years of age with gastroenteritis in Qom, Iran Prevalence of Adenovirus and Co-infection with Rotavirus
Gastroenterology and Hepatology from Bed to Bench,
,
https://doi.org/10.22037/ghfbb.v15i3.2483
Abstract
Aim: The current study is the first performed in Qom to determine the prevalence of adenovirus and co-infections with rotavirus in children aged <15 years with gastroenteritis symptoms.
Background: Gastroenteritis-associated viral infections are a cause of death among young children worldwide, especially in developing countries. The Adenovirus species F (40 and 41) are responsible for a range of acute diarrhea cases among infants and children.
Methods: Over a period of 9 months, a total of 130 children suffering from intestinal problems who referred to the infectious ward of Children's Hospital were enrolled in the current study. After clinical examination and collection of demographic information, fecal samples were obtained from the patients. Viral genomes were extracted with a commercial kit and amplified and typed by adenovirus-specific PCR assay. Adenovirus-positive samples were also evaluated for co-infection with rotavirus.
Results: Patients had a mean±SD age of 2.66±2.72 years; 63.1% of patients were male and 36.9% were female. Adenovirus infection was identified in 23 cases (17.7%), 21 (91.0%) and 2 (9.0%) of which were type 41 and type 40, respectively. Fever was the most common clinical manifestation among adenovirus-positive patients. No significant difference was observed between adenovirus infection and clinical symptoms, seasonal pattern, or serum laboratory results. Co-infection was found in only 5 cases (21.7%).
Conclusion: This study was the first to demonstrate adenovirus infection with a relatively high prevalence among children, especially infants, in Qom. The findings further revealed co-infection with rotavirus, indicating a health problem in this region.
- Adenovirus, Rotavirus, Co-infection, Gastroenteritis
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References
King CK, Glass R, Bresee JS, Duggan C; Centers for Disease Control and Prevention. Managing acute gastroenteritis among children: oral rehydration, maintenance, and nutritional therapy. MMWR Recomm Rep 2003;52:1-16.
Shane AL, Mody RK, Crump JA, Tarr PI, Steiner TS, Kotloff K, et al. 2017 Infectious Diseases Society of America clinical practice guidelines for the diagnosis and management of infectious diarrhea. Clin Infect Dis 2017;65:45-80.
Santosham M. Oral rehydration therapy: Reverse transfer of technology. Arch Pediat Adolesc Med 2002;156:1177-79.
Wilhelmi I, Roman E, Sanchez-Fauquier A. Viruses causing gastroenteritis. Clin Microbiol Infect 2003;9:247-262.
Chow CM, Leung AK, Hon KL. Acute gastroenteritis: From guidelines to real life. Clin Exp Gastroenterol 2010;3:97-112.
Khanal S, Ghimire P, Dhamoon A. The repertoire of adenovirus in human disease: The innocuous to the deadly. Biomedicines 2018;6:30.
Lynch JP 3rd, Fishbein M, Echavarria M. Adenovirus. Semin Respir Crit Care Med 2011;32:494-511.
Ghebremedhin B. Human adenovirus: Viral pathogen with increasing importance. Eur J Microbiol Immunol 2014;4:26-33.
Echavarría M. Adenoviruses in immunocompromised hosts. Clin Microbiol Rev 2008;21:704-715.
Najafi A, Najafi S, Vahdat K, Kargar M, Javdani N. Importance of viral pathogens in children with acute gastroenteritis in the south of Iran. Ann Saudi Med 2013;33:124-129.
Allard A, Girones R, Juto P, Wadell G. Polymerase chain reaction for detection of adenoviruses in stool samples. J Clin Microbiol 1990;28:2659-67.
Aminu M, Ahmad A, Umoh J, De Beer M, Esona M, Steele A. Adenovirus infection in children with diarrhea disease in Northwestern Nigeria. Ann Afr Med 2007;6:168-73.
Faden H, Wilby M, Hainer Z-D, Rush-Wilson K, Ramani R, Lamson D, et al. Pediatric adenovirus infection: relationship of clinical spectrum, seasonal distribution, and serotype. Clin Pediat 2011;50:483-87.
Sharifipour E, Shams S, Esmkhani M, Khodadadi J, Fotouhi-Ardakani R, Koohpaei A, et al. Evaluation of bacterial co-infections of the respiratory tract in COVID-19 patients admitted to ICU. BMC Infect Dis 2020;20:646.
Romo-Saenz CI, Medina-Soltero MR, Delgado-Gardea M, Carmen E, Zavala-Diaz de la Serna FJ, Tamez-Guerra P, et al. Human enteric circulating viruses and co-infections among hospitalized children with severe acute gastroenteritis in Chihuahua, Mexico, during 2010-2011. Jundishapur J Microbiol 2020;13:95010.
Makimaa H, Ingle H, Baldridge MT. Enteric viral co-infections: Pathogenesis and perspective. Viruses 2020;12:904.
Motamedifar M, Amini E, Shirazi PT. Frequency of rotavirus and adenovirus gastroenteritis among children in Shiraz, Iran. Iran Red Crescent Med J 2013;15:729-33.
Sanaei Dashti A, Ghahremani P, Hashempoor T, Karimi A. Molecular epidemiology of enteric adenovirus gastroenteritis in under-five-year-old children in Iran. Gastroenterol Res Prac 2016;2016:2045697.
Shokrollahi MR, Noorbakhsh S, Monavari HR, Darestani SG, Motlagh AV, Nia SJ. Acute nonbacterial gastroenteritis in hospitalized children: a cross sectional study. Jundishapur J Microbiol 2014;7:e11840.
Yousefi M, Nejati A, Zahraei SM, Mahmoudi S, Parhizgari N, Farsani SMJ, et al. Enteroviruses and Adenoviruses in stool specimens of paralytic children-can they be the cause of paralysis? Iran J Microbiol 2018:10:194.
Xu W, McDonough MC, Erdman DD. Species-specific identification of human adenoviruses by a multiplex PCR assay. J Clin Microbiol 2000:38:4114-20.
Shams S, Nasab SDM, Heydari H, Tafaroji J, Ahmadi N, Afzali ES. Detection and characterization of rotavirus G and P types from children with acute gastroenteritis in Qom, central Iran. Gastroenterol Hepatol Bed Bench 2020:13:128.
Pereira Filho E, da Costa Faria NR, Fialho AM, de Assis RS, Almeida MMS, Rocha M, et al. Adenoviruses associated with acute gastroenteritis in hospitalized and community children up to 5 years old in Rio de Janeiro and Salvador, Brazil. J Med Microbiol 2007;56:313-19.
Nasab SDM, Sabahi F, Makvandi M, Samiee SM, Nadji SA, Ravanshad M. Epidemiology of rotavirus-norovirus co-infection and determination of norovirus genogrouping among children with acute gastroenteritis in Tehran, Iran. Iran Biomed J 2016;20:280-86.
Ikner LA, Gerba CP. Adenoviruses. In: Quah S, Cockerham WC, eds. International Encyclopedia of Public Health: Cambridge, Massachusetts, United States: Elsevier Science; 2016.
Bonot S, Ogorzaly L, El Moualij B, Zorzi W, Cauchie H-M. Detection of small amounts of human adenoviruses in stools: Comparison of a new immuno real-time PCR assay with classical tools. Clin Microbiol Infect 2014;20:1010-16.
Samarbaf-Zadeh A, Pirmoradi R, Shamsizadeh A, Makvandi M. Prevalence of adenoviruses 40 and 41 in children less than five years suffering from acute gastroenteritis hospitalized in Ahvaz Abuzar Hospital. Jundishapur J Microbiol 2010;3:48-52.
Hamkar R, Yahyapour Y, Noroozi M, Nourijelyani K, Jalilvand S, Adibi L, et al. Prevalence of rotavirus, adenovirus, and astrovirus infections among patients with acute gastroenteritis in, Northern Iran. Iran J Public Health 2010;39:45-51.
Damavand B, Azimzadeh P, Mohebbi SR, Romani S, Majidizadeh Bozorgi S, Jadali F, et al. Prevalence of adenovirus infection and the dominant serotype among patients with acute gastroenteritis in Tehran between May 2008 and May 2009. Medical Science Journal of Islamic Azad Univesity-Tehran Medical Branch 2013:23:59-63. [In Persian]
Arashkia A, Bahrami F, Farsi M, Nejati B, Jalilvand S, Nateghian A, et al. Molecular analysis of human adenoviruses in hospitalized children < 5 years old with acute gastroenteritis in Tehran, Iran. J Med Virol 2019:91:1930-1936.
Modarres S, Modarres FJ-AS. Enteric adenovirus infection in infants and young children with acute gastroenteritis in Tehran. Acta Med Iran 2006;44:349-53.
Grimwood K, Carzino R, Barnes GL, Bishop RF. Patients with enteric adenovirus gastroenteritis admitted to an Australian pediatric teaching hospital from 1981 to 1992. J Clin Microbiol 1995;33:131-36.
Bon F, Fascia P, Dauvergne M, Tenenbaum D, Planson H, Petion A, et al. Prevalence of group A rotavirus, human calicivirus, astrovirus, and adenovirus type 40 and 41 infections among children with acute gastroenteritis in Dijon, France. J Clin Microbiol 1999;37:3055-58.
Li L, Phan TG, Nguyen TA, Kim KS, Seo JK, Shimizu H, et al. Molecular epidemiology of adenovirus infection among pediatric population with diarrhea in Asia. Microbiol Immunol 2005;49:121-28.
Herrmann JE, Blacklow NR, Perron-Henry DM, Clements E, Taylor DN, Echeverria P. Incidence of enteric adenoviruses among children in Thailand and the significance of these viruses in gastroenteritis. J Clin Microbiol 1988;26:1783-86.
Jarecki-Khan K, Tzipori SR, Unicomb LE. Enteric adenovirus infection among infants with diarrhea in rural Bangladesh. J Clin Microbiol 1993;31:484-89.
Yassin BAG, Ali SHM, Abu Al-ess HQM, Mohammed KIA, Al-Timimi MF, Al-Janabi MKW, et al. A trend of seasonality of enteric adenoviral gastroenteritis in pediatric patients less than five years from Baghdad. J Res Med Dent Sci 2018;6:18-23.
Rezaei M, Sohrabi A, Edalat R, Siadat SD, Gomari H, Rezaei M, Gilani SM. Molecular epidemiology of acute gastroenteritis caused by subgenus F (40, 41) enteric adenoviruses in inpatient children. Lab Med 2012;43:10-15.
Tang X, Hu Y, Zhong X, Xu H. Molecular epidemiology of human adenovirus, astrovirus, and sapovirus among outpatient children with acute diarrhea in Chongqing, China, 2017–2019. Front Pediatr 2022;10:826600.
Kamal Allayeh A, Mostafa El Baz R, Mohamed Saeed N, El Sayed Osman M. Detection and genotyping of viral gastroenteritis in hospitalized children below five years old in Cairo, Egypt. Arch Pediatr Infect Dis 2018;6:e60288.
Liu L, Qian Y, Zhang Y, Zhao L, Jia L, Dong H. Epidemiological aspects of rotavirus and adenovirus in hospitalized children with diarrhea: A 5-year survey in Beijing. BMC Infect Dis 2016;16:508-15.
Kotloff KL, Losonsky GA, Morris JG, Wasserman SS, Singh-Naz N, Levine MM. Enteric adenovirus infection and childhood diarrhea: An epidemiologic study in three clinical settings. Pediatrics 1989;84:219-25.
Khoshdel A, Parvin N, Doosti A, Famouri F. Prevalence of Nosocomial Diarrhea Due to Adenoviruses 40 and 41 in a Paediatric Ward in Iran. J Clin Diagn Res 2015;9:SC15-7.
Akan H, İzbırak G, Gürol Y, Sarıkaya S, Gündüz TS, Yılmaz G, et al. Rotavirus and adenovirus frequency among patients with acute gastroenteritis and their relationship to clinical parameters: A retrospective study in Turkey. Asia Pac Fam Med 2009:8:8.
Oyinloye S, Misherima K. Detection of Rotavirus and Adenovirus in Diarrhoeic Stool of Children at a Primary Health Care Centre, Borno State. Research Journal of Science 2018;18:60-66.
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