ISSN: 2008-2258
Vol 16, No 1 (2023): Winter
The role of moderate and high intensity supervised aerobic training in reducing steatosis and hepatic fibrosis in patients with non-alcoholic fatty liver disease; A randomized clinical trial
Gastroenterology and Hepatology from Bed to Bench,
,
https://doi.org/10.22037/ghfbb.v16i1.2466
Abstract
Introduction: Exercise is probably regarded as an appropriate way to prevent and treat Non-Alcoholic Fatty Liver Disease (NAFLD) - the most common chronic liver disease. This study aimed to evaluate the effect of the same volume of moderate and high intensity aerobic exercise on patients' liver status.
Methods: This study was performed as a parallel RCT on 60 patients with NAFLD in 3 groups of 20 people. 40 patients remained in the study after 6 months of follow up. Fibrosis and steatosis of liver including Control Attenuated Parameter (CAP) determined by fibroscan device.
The control group, as a routine management, was advised to adjust their lifestyle and received nutritional recommendations. The intervention groups additionally, participated on supervised exercise programs with two different intestines but the same volume of 1000 KCal per week. The intensities of 50 and 70 percent of V02 reserve were considered for moderate and vigorous programs respectively.
Results: On 6 months’ follow-ups, the mean of CAP scores changes were -20 (P=0.04), -10 (P=0.001), and -15 (P=0.002) within control, moderate, and high intensity groups, respectively. In the intervention groups, in addition to steatosis, this difference was also observed in the rate of fibrosis. The means of fibrosis changes were 0 (P=0.85), -0.5 (P=0.05), and -0.7 (<0.0001) within control, moderate, and high intensity groups, respectively. No significant differences between groups could be detected in steatosis, fibrosis, anthropometric, and laboratory findings were found.
Conclusion:
The data yielded by the present study appear to suggest that independent of intensity, aerobic exercise can improve the course of fibrosis and steatosis in NAFLD patients.
- aerobic training
- hepatic fibrosis
- steatosis
- non-alcoholic fatty liver disease
How to Cite
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