Assessment of Common and Differentially Expressed Proteins between Diabetes Mellitus and Fatty Liver Disease: A Network Analysis
Gastroenterology and Hepatology from Bed to Bench,
30 December 2021
AbstractBack ground: Nonalcoholic fatty liver disease (NFLD) is a chronic hepatic failure with broad range of hepatic disorders. NFLD and diabetes type 2 coexist regularly to drive adverse outcome as hepatocellular carcinoma and vascular complications.
Aim: This study aimed to introduce main biomarkers related to NFLD and diabetes II to find out common pathogenic and metabolite factors linked NFLD to diabetes II
Methods: The related proteins to NFDL and diabetes mellitus extracted from String database. Proteins related to each disease were included in protein-protein interaction network via Cytoscape software. Obtained networks were analyzed via Cytoscape network analyzer. The central nodes were determined as top hubs based on degree value. Top hubs related to NFLD and diabetes melliteswere compared.
Results: 200 proteins related to NFDL and diabetes mellitus were found via String database separately and connected via undirected edges in individual networks. Central nodes based on degree value were determined for each disease. 10 percent of top nodes were selected based on degree value as 20 top hubs for each disease. Target common hub proteins between NFDL and diabetes mellitus are: INS, AKT1, ALB, PPARG, IL6, GPDPH, LEP, TNF, ADIPOQ, IGF1, TP53, MAPK3, and SIRT1
According to the results, 13 common and 14 discriminatory central dysregulated proteins were determined for NAFLD and diabetes mellitus.
- Nonalcoholic fatty liver disease, Diabetes mellitus, Network analysis, Bioinformatics, Biomarkers
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