Side effects of Omeprazole: a System Biology study Side effects of omeprazole: a system biology study
Gastroenterology and Hepatology from Bed to Bench,
Vol. 14 No. 4 (2021),
23 August 2021
https://doi.org/10.22037/ghfbb.v14i4.2269
Abstract
Background: Omeprazole as a proton pump inhibitor has a widespread consumption to inhibit gastric acid secretion. Assessment of omeprazole effects on human cardiovascular system is the main aim of this study.
Methods: Gene expression profiles of “human coronary artery endothelial cells” in the absence and presence of omeprazole is downloaded from gene expression omnibus (GEO). The differentially expressed genes (DEGs) are interacted as an interactome and the hub nodes are determined. The DEGs are enriched via gene ontology (GO) analysis. The critical hubs are identified based on GO finding.
Results: Among 103 queried DEGs 61 individuals were included in the main connected component. CTNNB1, HNRNPA1, SRSF4, TRA2A, SFPQ, and RBM5 genes are identified as critical hub genes. Six clusters of biological terms were introduced as deregulated elements in the presence of omeprazole.
Conclusion: In conclusion, long time consumption of omeprazole may be accompanied with undesirable effects, however more evidences are required.
Keywords:
- Omeprazole; system biology; Network analysis
How to Cite
Hamzeloo-Moghadam, M. ., Rezaei –Tavirani, M., Jahani-Sherafat, S., Rezaei Tavirani, S. ., Esmaeili, S., Ansari, M. ., & Ahmadzadeh, A. . (2021). Side effects of Omeprazole: a System Biology study: Side effects of omeprazole: a system biology study . Gastroenterology and Hepatology from Bed to Bench, 14(4). https://doi.org/10.22037/ghfbb.v14i4.2269
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2. CHEN J-y, WANG M-x, WANG H-m. Study on effect of pantoprazole, omeprazole and famotidine on treatment of peptic ulcer [J]. Modern Medicine & Health. 2010;11.
3. Rameau A, Andreadis K, Bayoumi A, Kaufman M, Belafsky P. Side Effects of Proton Pump Inhibitors: What are Patients’ Concerns? Journal of Voice. 2020.
4. Amiri-Dashatan N, Koushki M, Abbaszadeh H-A, Rostami-Nejad M, Rezaei-Tavirani M. Proteomics applications in health: biomarker and drug discovery and food industry. Iranian journal of pharmaceutical research: IJPR. 2018;17(4):1523.
5. Deng L, Xiong P, Luo Y, Bu X, Qian S, Zhong W. Bioinformatics analysis of the molecular mechanism of diffuse intrinsic pontine glioma. Oncology letters. 2016;12(4):2524-30.
6. Xia J, Sun J, Jia P, Zhao Z. Do cancer proteins really interact strongly in the human protein–protein interaction network? Computational biology and chemistry. 2011;35(3):121-5.
7. Kong B, Yang T, Chen L, Kuang Y-q, Gu J-w, Xia X, et al. Protein–protein interaction network analysis and gene set enrichment analysis in epilepsy patients with brain cancer. Journal of Clinical Neuroscience. 2014;21(2):316-9.
8. Ren G, Liu Z. NetCAD: a network analysis tool for coronary artery disease-associated PPI network. Bioinformatics. 2013;29(2):279-80.
9. Schlicker A, Domingues FS, Rahnenführer J, Lengauer T. A new measure for functional similarity of gene products based on Gene Ontology. BMC bioinformatics. 2006;7(1):302.
10. Ovaska K, Laakso M, Hautaniemi S. Fast Gene Ontology based clustering for microarray experiments. BioData mining. 2008;1(1):11.
11. Costarelli L, Giacconi R, Malavolta M, Basso A, Piacenza F, Provinciali M, et al. Different transcriptional profiling between senescent and non-senescent human coronary artery endothelial cells (HCAECs) by Omeprazole and Lansoprazole treatment. Biogerontology. 2017;18(2):217-36.
12. Rezaei-Tavirani M, Tavirani MR, Azodi MZ, Farshi HM, Razzaghi M. Evaluation of skin response after erbium: yttrium–aluminum–garnet laser irradiation: a network analysis approach. Journal of lasers in medical sciences. 2019;10(3):194.
13. Rezaei-Tavirani M, Rezaei-Tavirani S, Ahmadi N, Naderi N, Abdi S. Pancreatic adenocarcinoma protein-protein interaction network analysis. Gastroenterology and Hepatology from bed to bench. 2017;10(Suppl1):S85.
14. Rezaei-Tavirani M, Mansouri V, Tavirani MR, Rostami-Nejad M, Bashash D, Azodi MZ. Gene and Biochemical Pathway Evaluation of Burns Injury via Protein-Protein Interaction Network Analysis. Galen Medical Journal. 2019;8:1257.
15. Maton PN. Omeprazole. New England Journal of Medicine. 1991;324(14):965-75.
16. ZHOU Y, QIAO L, WU J, HU H, XU C. Comparison of the efficacy of octreotide, vasopressin, and omeprazole in the control of acute bleeding in patients with portal hypertensive gastropathy: a controlled study. Journal of gastroenterology and hepatology. 2002;17(9):973-9.
17. Kuechler A, Willemsen MH, Albrecht B, Bacino CA, Bartholomew DW, van Bokhoven H, et al. De novo mutations in beta-catenin (CTNNB1) appear to be a frequent cause of intellectual disability: expanding the mutational and clinical spectrum. Human genetics. 2015;134(1):97-109.
18. Kharbanda M, Pilz DT, Tomkins S, Chandler K, Saggar A, Fryer A, et al. Clinical features associated with CTNNB1 de novo loss of function mutations in ten individuals. European journal of medical genetics. 2017;60(2):130-5.
19. Li M, Hu X, Zhu J, Zhu C, Zhu S, Liu X, et al. Overexpression of miR-19b impairs cardiac development in zebrafish by targeting ctnnb1. Cellular Physiology and Biochemistry. 2014;33(6):1988-2002.
20. Palacios J, Gamallo C. Mutations in the β-catenin gene (CTNNB1) in endometrioid ovarian carcinomas. Cancer research. 1998;58(7):1344-7.
21. Dobrosotskaya IY, James GL. MAGI-1 interacts with β-catenin and is associated with cell–cell adhesion structures. Biochemical and biophysical research communications. 2000;270(3):903-9.
22. Cotter L, Özçelik M, Jacob C, Pereira JA, Locher V, Baumann R, et al. Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelination. Science. 2010;328(5984):1415-8.
23. Ribeiro M, Furtado M, Martins S, Carvalho T, Carmo-Fonseca M. RNA Splicing Defects in Hypertrophic Cardiomyopathy: Implications for Diagnosis and Therapy. International Journal of Molecular Sciences. 2020;21(4):1329.
24. Umbria M, Ramos A, Aluja MP, Santos C. The role of control region mitochondrial DNA mutations in cardiovascular disease: stroke and myocardial infarction. Scientific Reports. 2020;10(1):1-10.
25. Wei M, Gan L, Liu Z, Liu L, Chang J-R, Yin D-C, et al. Mitochondrial-Derived Peptide MOTS-c Attenuates Vascular Calcification and Secondary Myocardial Remodeling via Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway. Cardiorenal medicine. 2020;10(1):42-50.
26. Glanz VY, Sobenin IA, Grechko AV, Yet S-F, Orekhov AN. The role of mitochondria in cardiovascular diseases related to atherosclerosis. Frontiers in bioscience (Elite edition). 2020;12:102-12.
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