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  3. Vol 14, No 4 (2021): Autumn
  4. Original Article

ISSN: 2008-2258

Vol 14, No 4 (2021): Autumn

Efficacy of levofloxacin, omeprazole, nitazoxanide, and doxycycline (LOAD) regimen compared with standard triple therapy to eradicate Helicobacter pylori infection: a prospective randomized study from a tertiary hospital in India comparison of LOAD and Standard triple therapy in eradication of h.pylori infection.

  • HAMEED RAINA
  • Rajesh Sainani
  • Arshed Parray
  • Abdul Haseeb Wani
  • Umaymah Ashraf
  • Manzoor Ahmad Raina

Gastroenterology and Hepatology from Bed to Bench, ,
https://doi.org/10.22037/ghfbb.v14i4.2256 Published 23 August 2021

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Abstract

Introduction/Aim  : 


Helicobacter pylorus is a widespread infection in India. Resistance to commonly used antibiotics against Helicobacter pylori increases rapidly, leading to traditional triple therapy's lower success. So, a search for a new regimen is needed.


In this study, we compared the efficacy of  14-day triple therapy with a novel ten-day LOAD regimen to eradicate Helicobacter pylori infection in India .


Methods:


 In this randomized trial, patients with Helicobacter pylori infection were randomized to LOAD therapy (levofloxacin 250 mg OD, omeprazole 40 mg BD,  nitazoxanide 500mg BD, and doxycycline  100 mg OD) for ten days and standard triple therapy ( pantoprazole 80 mg, amoxicillin 2000 mg, and clarithromycin 1000 mg daily in divided doses for 14 days ). Gastric biopsy/RUT  was done 10–12 weeks after completing therapy to confirm Helicobacter pylori eradication.


Result :


The eradication rates with LOAD regimen  were significantly greater than with standard triple therapy on both intention-to-treat analysis (82.75 % vs. 60.26 %, p = 0.001; difference, 22.49 % [95 % CI, 8.5-18 %] and per-protocol analysis (83.3 % vs. 62.75 %, p = 0.002; difference, 20.55 % [95 % CI, 7.1-22.5 %]). Both the treatment regimens were well tolerated.


Conclusion :


Although the rate of eradication of H. pylori infection with the LOAD regimen was significantly higher than that with triple therapy, the efficacy was still suboptimal. It may be due to fluoroquinolone resistance or a short course of treatment.

Keywords:
  • Helicobacter pylori. LOAD regimen, Standard triple therapy.Eradication
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How to Cite

RAINA, H., Sainani, R., Parray , A., Wani , A. H., Ashraf , U., & Manzoor Ahmad Raina. (2021). Efficacy of levofloxacin, omeprazole, nitazoxanide, and doxycycline (LOAD) regimen compared with standard triple therapy to eradicate Helicobacter pylori infection: a prospective randomized study from a tertiary hospital in India : comparison of LOAD and Standard triple therapy in eradication of h.pylori infection. Gastroenterology and Hepatology from Bed to Bench, 14(4). https://doi.org/10.22037/ghfbb.v14i4.2256
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References

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Print ISSN: 2008-2258
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