The potentials of probiotics on gluten hydrolysis; a review study
Gastroenterology and Hepatology from Bed to Bench,
Vol. 13 No. Supplement 1 (2020),
9 Azar 2020
,
Page S1-S7
https://doi.org/10.22037/ghfbb.v13i1.2245
Abstract
Celiac disease (CD) is an autoimmune disorder of the small intestinal mucosa in genetically susceptible subjects consuming gluten. Gluten in wheat, rye and barley is harmful for some individuals and leads to various symptoms. Research has shown that treatment with probiotics in CD patients could improve the symptoms by the gluten hydrolysis. For this purpose, different databases such as Medline, PubMed, Scopus, and Google Scholar were searched using the following keywords: Celiac disease, Wheat flour, Gluten, glutamine, Probiotic, Bifidobacterium, Lactobacillus, Enzymes, Wheat allergy, Immune system, T cells, HLA-DQ2, HLA-DQ8, Gluten-free diet, Proteolysis, α2-gliadin fragment, Gliadin, 33-mer peptide, and Zonulin. The search aimed to retrieve the articles published during 2000-2019. Today, a gluten-free diet (GFD) is the only celiac disease treatment. Biotechnological strategy based on probiotic treatment could degrade gluten. Research has shown that combination of the probiotic enzyme is more effective than single probiotic on gluten hydrolysis. The result of different studies showed that probiotic mixture has the capacity to hydrolyze a considerable concentration of the 33-mer of gliadin completely. The present study was aimed to investigate associations between the capacities of probiotics on gluten hydrolysis.
Keywords: Celiac disease, Gliadin, Gluten-free diet, Probiotics, Wheat.
(Please cite as: Ramedani N, Sharifan A, Gholam-Mostafaei FS, Rostami-Nejad M, Yadegar A, Moham Ehsani-Ardakani MJ. The potentials of probiotics on gluten hydrolysis; a review study. Gastroenterol Hepatol Bed Bench 2020;13(Suppl.1):S1-S7).
- • Celiac disease, Gliadin, Gluten-free diet, Probiotics, Wheat×
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References
Rostami K, Marsh MN, Johnson MW, Mohaghegh H, Heal C, Holmes G, et al. ROC-king onwards: intraepithelial lymphocyte counts, distribution & role in coeliac disease mucosal interpretation. Gut 2017;66:2080-2086.
Kamboj AK, Oxentenko AS. Clinical and Histologic Mimickers of Celiac Disease. Clin Transl Gastroenterol 2017;8:e114.
Ehsani-Ardakani MJ, Rostami-Nejad M, Villanacci V, Volta U, Manenti S, Caio G,et al. Gastrointestinal and Non-Gastrointestinal Presentation in Patients with Celiac Disease. Arch Iran Med 2013;16:78-82.
Mustalahti K, Catassi C, Reunanen A, Fabiani E, Heier M, McMillan S, et al. The prevalence of celiac disease in Europe: results of a centralized, international mass screening project. Ann Med 2010;42:587-95.
Gujral N, Freeman H, Thomson A. Celiac disease: Prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol 2012;18:6036-59.
Clemente E, Efthymakis K, Carletti E, Capone V, Sperduti S, Bologna G, et al. An explorative study identifies miRNA signatures for the diagnosis of non-celiac wheat sensitivity. PLoS One 2019;14:e0226478.
Bascunan KA, Araya M, Roncoroni L, Doneda L, Elli L. Dietary Gluten as a Conditioning Factor of the Gut Microbiota in Celiac Disease. Am Soc for Nutr 2019;1-15.
Francavilla R, De Angelis M, Giuseppe Rizzello C, Cavallo N, Dal Bello F, Gobbettid M, Selected Probiotic Lactobacilli Have the Capacity to Hydrolyze Gluten Peptides during Simulated Gastrointestinal Digestion. Appl Environ Microbiol 2017; 83:1-12.
Kumar J, Kumar M, Pandey R, Chauhan N. Physiopathology and Management of Gluten-Induced Celiac Disease. J Food Sci 2017;82:270-7.
Boyce JA, Assa’ad A, Burks AW, Jones SM, Sampson HA, Wood RA, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol 2010;126:S1-58.
Hofer G, Wieser S, Bogdos MK, Gattinger P, Nakamura R, Ebisawa M, et al. Three-dimensional structure of the wheat β-amylase Tri a 17, a clinically relevant food allergen. Allergy 2019;74:1009-13.
Cianferoni A. Wheat allergy: diagnosis and management. J Asthma Allergy 2016;9:13-25.
Helmerhorst EJ, Zamakhchari M, Schuppan D, Oppenheim FG. Discovery of a novel and rich source of gluten–degrading microbial enzymes in the oral cavity. PLoS One 2010;5:e13264.
Meresse B, Malamut G, Cerf-Bensussan N. Celiac Disease: An Immunological Jigsaw. Immunity 2012;36:907-19.
Schalk K, Lang CH, Wieser H, Koehler P, Anne Scherf K. Quantitation of the immunodominant 33-mer peptide from α-gliadin in wheat flours by liquid chromatography tandem mass spectrometry. Sci Rep 2017;7:45092.
Caputo I, Lepretti M, Martucciello S, Esposito C. Enzymatic Strategies to Detoxify Gluten: Implications for Celiac Disease. Enzyme Res 2010;1-9.
Catassi C, Fabiani E, Iacono G, D'Agate C, Francavilla R, Biagi F, et al. Am J Clin Nutr 2007;85:160-6.
Gilissen LJWJ, Van der Meer IM, Smulders MJM. Why Oats Are Safe and Healthy for Celiac Disease Patients. Med Sci 2016;4:1-9.
Lerner BA, Phan Vo LT, Yates S, Rundle AG, Green PHR, Lebwohl B. Detection of Gluten in Gluten-Free Labeled Restaurant Food: Analysis of Crowd-Sourced Data. Am J Gastroenterol 2019;114:792-7.
Chibbar R, Dieleman LA. The Gut Microbiota in Celiac Disease and probiotics. Nutrients 2019;11:2375.
De Sousa Morae LF, Grzeskowiak LM, de Sales Teixeira TF. and Gouveia Peluzio, Mdo.C. Intestinal microbiota and probiotics in celiac disease. Clin Microbiol Rev 2014;27:482-9.
Food and Agriculture Organization of the United Nations, World Health Organization. 2002. Guidelines for the evaluation of probiotics in food. World Health Organization, Geneva, Switzerland. Accessed 27 April 2014.
Ghouri YA, Richards DM, Rahimi EF, Krill JT, Jelinek KA, DuPont AW. Systematic review of randomized controlled trials of probiotics, prebiotics, and synbiotics in inflammatory bowel disease. Clin Exp Gastroenterol 2014;7:473-87.
De Angelis M, Rizzelo CG, Fasano A, Clemente MG, De Simone C, Silano M, et al. VSL#3 probiotic preparation has the capacity to hydrolyze gliadin polypeptides responsible for celiac sprue. Biochim Biophys Acta 2006;1762:80-93.
Lukic J, Chen V, Strahinic I, Begovic J, Lev-Tov H, Davis SC, et al. Probiotics or pro-healers: the role of beneficial bacteria in tissue repair. Wound Repair Regen 2017;25:912-22.
Ash, M. The Golden Age of Gluten Free Living: New Findings, Tests and Treatments. Clinical Education 2015
Siddiqi RA, Singh Sogi D, Sehajpa PK. Effect of short-term sourdough fermentation on wheat protein. Cogent Food Agric 2016;2:1132983:1-10.
Moreno-Amador ML, Arévalo-Rodríguez M, Durán EM, Martínez-Reyes JC, Sousa-Martín C. A new microbial gluten-degrading prolyl endopeptidase: Potential application in celiac disease to reduce gluten immunogenic peptides. PLoS One 2019;14:e0218346.
Volta U, Tovoli F, Cicola R, Parisi C, Fabbri A, Piscaglia M, et al. Serological tests in gluten sensitivity (nonceliac gluten intolerance). J Clin Gastroenterol 2012;46:680-5.
Greco L, Gobbetti M, Auricchio R, Di Mase R, Paparo F, Di Cagno R, et al. Safety for celiac disease of baked goods made of wheat flour hydrolyzed during food processing. Clin Gastroenterol Hepatol 2011;9:24-9.
Sahebekhtiari N, Nochi Z, Eslampour MA, Dabiri H, Bolfion M, Taherikalani M, et al. Characterization of Staphylococcus aureus strains isolated from raw milk of bovine subclinical mastitis in Tehran and Mashhad. Acta Microbiol Immunol Hung. 2011;58:113-21.
Socha P, Mickowska B, Urminska D, Kacmarova K. The use of different proteases to hydrolyze gliadins. J Microbiol Biotech Food Sci 2015;4:101-4.
Herran AR, Perez-Andres J, Caminero A, Nistal E, Vivas S, de Morales RJM, et al. Gluten-degrading bacteria are present in human small intestine of healthy volunteers and celiac patients. Res Microbiol 2017;168:673-84.
Olivares M, Laparra M, Sanz Y. Influence of Bifidobacterium longum CECT 7347 and gliadin peptides on intestinal epithelial cell proteome. J Agric Food Chem 2012;59:7666-71.
Shan L, Mathews II, Khosla C. Structural and mechanistic analysis of two prolyl endopeptidases: role of interdomain dynamics in catalysis and specificity. Proc Natl Acad Sci USA 2005;102:3599-604.
Watson P, Ding A, McMillan SA, et al. Implications of enzymatic detoxification of food gluten in coeliac disease. Gastroenterology 2008;134:A213.
Orlando A, Linsalata M, Notarnicola M, Tutino V, Russo F. Lactobacillus GG restoration of the gliadin induced epithelial barrier disruption: the role of cellular polyamines. BMC Microbiol 2014;14:1-12.
Cristofori F, Francavilla R, Capobianco D, Dargenio VN, Filardo S, Mastromarino P. Bacterial-Based Strategies to Hydrolyze Gluten Peptides and Protect Intestinal Mucosa. Front Immunol 2020;11:567801.
Keijzer C, van der Zee R, van Eden W, Broere F. Treg inducing adjuvants for therapeutic vaccination against chronic inflammatory diseases. Front Immunol 2013;4:1-10.
Veeraraghavan G, Leffler DA, Kaswala DH, Mukherjee R. Celiac disease update: new therapies. Expert Rev Gastroenterol Hepato 2015;19:913-27.
Sollid LM, Jabri B. Celiac disease and transglutaminase 2: a model for post–translational modification of antigens and HLA association in the pathogenesis of autoimmune disorders. Curr Opin Immunol 2011;23:732-8.
Makharia GK. Current and emerging therapy for celiac disease. Front Med 2014;1:1-14.
Kim CY, Quarsten H, Bergseng E, Bergseng E, Khosla C, Sollid LM. Structural basis for HLA–DQ2–mediated presentation of gluten epitopes in celiac disease. Proc Natl Acad Sci USA 2004;101:4175-9.
Schuppan D, Junker Y, Barisani D. Celiac disease: from pathogenesis to novel therapies. Gastroenterol 2009;137:1912-33.
Stoven S, Murray JA, Marietta E. Celiac Disease: Advances in Treatment via Gluten Modification. Clin Gastroenterol Hepatol 2012;10:859-62.
Stepniak D, Spaenij-Dekking L, Mitea C, Moester M, de Ru A, Baak-Pablo R, et al. Highly efficient gluten degradation with a newly identified prolyl endoprotease: implications for celiac disease. Am J Physiol Gastrointest Liver Physiol 2006;1-35.
Ehren J, Morón B, Martin E, Bethune MT, Gray GM, Khosla C. A food-grade enzyme preparation with modest gluten detoxification properties. PLoS One 2009;21:4.
Montserrat V, Bruins MJ, Edens L, Koning F. Influence of dietary components on Aspergillus niger prolyl endoprotease mediated gluten degradation. Food Chem 2015;1:440-5.
Kaukinen K. Lindfors K. Novel Treatments for Celiac Disease: Glutenases and Beyond. Dig Dis 2015;277-81.
Duar RM, Clark KJ, Patil PB, Hernández C, Brüning S, Burkey TE, et al. Identification and characterization of intestinal lactobacilli strains capable of degrading immunotoxic peptides present in gluten. J Appl Microbiol 2015;118:515-27.
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