Prevalence of Astrovirus, Adenovirus, Sapovirus infections among Iranian children with acute gastroenteritis
Gastroenterology and Hepatology from Bed to Bench,
9 December 2020
Aim: This study aimed to determine the prevalence of Human Astroviruses (HAstVs), enteric Adenoviruses (HAdVs), Sapoviruses (SaVs) in acute diarrhea patients, as well as their relation to age, sex and season.
Background: Acute gastroenteritis is one of the most common diseases affecting children <5 years old and viral agents with approximately >75% are most of the agents of acute infectious diarrhea. After Rotavirus and Norovirus, the greater viral agents of acute gastroenteritis include HAstVs, HAdVs, SaVs. To our best knowledge, there are the little study in Iran that were detected at least three enteric viruses as causative agents of diarrhea simultaneously.
Methods: The Sample was collected from children that referred to Children’s Medical Centers in Tehran, Iran and tested for Astrovirus, enteric Adenovirus, and Sapovirus by conventional PCR method. The association of incidence of viral enteric agents evaluated with age, sex and seasonal pattern in children <5 years old.
Results: The positive case number among acute gastroenteritis patients was 17/120 (14.1%). Patients ranged in age from 1–60 month but 52.9% were aged ≤ 12 months. Males comprised the majority (70.6), and the male: female ratio was 2.4. HAstV was the most frequently detected virus (6.7%), while SaVs were detected only by 2.5%. Mixed infections were not detected in these samples. The highest rate of HAstV was identified in winter (66.7%), HAdV in autumn (66.7%) and SaV in winter (33.3%)
Conclusion: These findings underscore the importance of monitoring the epidemiology of HAstV, HAdV, and SaV as agents of viral diarrhea infections.
- Gastroenteritis Virus, Astrovirus, Adenovirus, Sapovirus, Polymerase Chain Reaction
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