Lack of association between VEGF -2578C/A polymorphism and risk of colorectal cancer in an Iranian population
Gastroenterology and Hepatology from Bed to Bench,
,
9 December 2020
https://doi.org/10.22037/ghfbb.v13i1.2203
Abstract
Aim: Vascular endothelial growth factor (VEGF) is a key regulatory factor in angiogenesis and with essential roles in the development of malignancy in colorectal cancer (CRC), which is the third most prevalent cancer worldwide. Here we evaluated the VEGF gene -2578C/A polymorphism as a potential susceptibility factor in colorectal cancer (CRC) occurrence amongst Iranian CRC patients. M&M: VEGF -2578C/A polymorphism was evaluated in 200 CRC patients and 200 healthy control subjects using restriction fragment length polymorphism analysis methods. Results: The frequencies of CC, AC and AA genotypes among CRC patients were 22.5%, 51% and 26.5%, respectively and genotype frequencies were 16%, 54% and 30% in controls cohort respectively (P=0.247). The A allele frequency among case group was 52% and for control group, 57%. C allele frequency in case and control groups was 48% and 43%, respectively (p=0.156). No significant association between this polymorphism and CRC stage was observed (p=0.990). Conclusion: Our findings provide limited support for the hypothesis that the -2578C/A VEGF are associated with increased risk for Colorectal cancer in Iranian colorectal cancer patients and suggest instead that meta data studies, which have previously relied upon populations definitions such as ‘asian’, should more specifically take into account country of origin when associating prognostic value to a given genotype.
Keywords: Colorectal cancer, Angiogenesis, VEGF, Single Nucleotide Polymorphism, Vascular Endothelial Growth Factor
Keywords:
- Colorectal cancer, Angiogenesis, VEGF, Single Nucleotide Polymorphism, Vascular Endothelial Growth Factor
References
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1. Deschoolmeester, V.; Baay, M.; Specenier, P.; Lardon, F.; Vermorken, J. B. A Review of the Most Promising Biomarkers in Colorectal Cancer: One Step Closer to Targeted Therapy. The Oncologist 2010, 15(7), 699-731. doi:10.1634/theoncologist.2010-0025.
2. Qasim Alhilfia, H. S.; Mohsin Almohammadawi, K. O; Abduljalil Alsaad, R. K.; Ameen, N.A.; Abbood Aliedani, B. K.; Imran Aldubaisi, H. J.; Hussien Alshewered, A. S. Colorectal cancer epidemiology and clinical study in MisanEpidemiologia do câncer colorretal e estudo clínico em Misan. Journal of Coloproctology 2019, 39, (2), 159-162. doi: 10.1016/j.jcol.2018.12.001.
3. Haddad, F. G.; Eid, R.; Kourie, H. R., Barouky, E., Ghosn, M. Prognostic and predictive biomarkers in nonmetastatic colorectal cancers. Future Oncology 2018, 14:21. doi: 10.2217/fon-2017-0708.
4. Mo Bae, J.; Rhee, Y. Y.; Kim, K. J.; Wen, X.; Seok Song, Y.; Cho, N. Y.; Kim, J. H.; Kang, G. H. Are clinicopathological features of colorectal cancers with methylation in half of CpG island methylator phenotype panel markers different from those of CpG island methylator phenotype–high colorectal cancers? Human Pathology 2016, 47, 85-94. doi: 10.1016/j.humpath.2015.09.008.
5. Chayeb, V.; Mahjoub, S.; Zitouni, H.; Jrah-Harzallah, H.; Zouari, K. Contribution of microRNA-149, microRNA-146a, and microRNA-196a2 SNPs in colorectal cancer risk and clinicopathological features in Tunisia. Gene 2018, 666, 100-107. doi: 10.1016/j.gene.2018.04.084.
6. Yee, Y. K.; Tan, V. P.; Chan, P.; Hung, I. F.; Pang, R.; Wong, B. C. Y. Epidemiology of colorectal cancer in Asia. J Gastroenterol Hepatol 2009, 24(12), 1810-6.
7. Crockett, S. D.; Nagtegaal, I. Terminology, Molecular Features, Epidemiology, and Management of Serrated Colorectal Neoplasia. Gastroenterology 2019, (In Press). doi: 10.1053/j.gastro.2019.06.041.
8. Yamazaki, K.; Taniguchi, H.; Yoshino, T.; Akagi, K.; Ishida, H.; Ebi, H.; Nakatani, K.; Muro, K.; Yatabe, Y.; Yamaguchi, K. Japanese Society of Medical Oncology Clinical Guidelines: Molecular Testing for Colorectal Cancer Treatment, Third Edition. Cancer Sci 2018, 109(6), 2074-2079. doi: 10.1111/cas.13617
9. Du, W.; Ma, X. L.; Zhao, C.; Liu, T.; Du, Y. L.; Kong, W. Q.; Wei, B. L.; Yu, J. Y.; Li, Y. Y.; Huang, J. W.; et al. Associations of single nucleotide polymorphisms in miR-146a, miR-196a, miR-149 and miR-499 with colorectal cancer susceptibility. Asian Pac J Cancer Prev 2014, 15(2), 1047-1055. doi: 10.7314/apjcp.2014.15.2.1047.
10. Liu, Y.; Lin, X. F.; Lin, C. J.; Jin, S. S.; Wu, J.M. Transforming growth factor beta-1 C-509T polymorphism and cancer risk: a meta-analysis of 55 case-control studies. Asian Pacific Journal of Cancer Prevention 2012, 13(9), 4683-4688. doi: 10.7314/apjcp.2012.13.9.4683.
11. Yue, A. M.; Xie, Z. B.; Zhao, H. F.; Guo, S. P.; Shen, Y. H.; Wang, H. P. Associations of ABCB1 and XPC genetic polymorphisms with susceptibility to colorectal cancer and therapeutic prognosis in a Chinese population. Asian Pac J Cancer Prev 2013, 14(5), 3085-3091. doi: 10.7314/apjcp.2013.14.5.3085.
12. Aizat, A. A.; Shahpudin, S. N.; Mustapha, M. A.; Zakaria, Z.; Sidek, A. S.; Abu Hassan, M. R.; Ankathil, R. Association of Arg72Pro of P53 polymorphism with colorectal cancer susceptibility risk in Malaysian population. Asian Pac J Cancer Prev 2011, 12(11), p. 2909-2913. PMID: 22393962.
13. Zhang, Y.; Zhang, D.; Zhao, L.; Lili Sun, L.; Dong, Q.; Cheng, L.; Cheng, R. Association between p53 Arg72Pro polymorphism and colorectal cancer risk in Asian population: a meta-analysis. Current Problems in Cancer 2018, 42: 6, 582-592. doi: 10.1016/j.currproblcancer.2018.08.007.
14. Saeed, H. M.; Alanazi, M. S.; Parine, N. R.; Shaik, J.; Semlali, A.; Alharbi, O.; Azzam, N.; Aljebreen, A.; Almadi, M.; Shalaby, M. A. Matrix metalloproteinase-2 (-1306 c > t) promoter polymorphism and risk of colorectal cancer in the Saudi population. Asian Pac J Cancer Prev 2013, 14, 6025-6030. doi: 10.7314/apjcp.2013.14.10.6025.
15. Canavese, M.; Ngo, D. T.; Maddern, G. J.; Hardingham, J. E.; Price, T. J.; Hauben, E. Biology and therapeutic implications of VEGF-A splice isoforms and single-nucleotide polymorphisms in colorectal cancer. International Journal of Cancer 2017, 140, 10, 2183-2191. Doi: 10.1002/ijc.30567.
16. Nishida, N.; Yano, H.; Nishida, T.; Kamura, T.; Kojiro, M. Angiogenesis in cancer. Vasc Health Risk Manag 2016, 2(3), 213-9. doi:10.2147/vhrm.2006.2.3.213.
17. Ruhrberg, C. Endogenous inhibitors of angiogenesis. Journal of cell science 2001, 114(18), 3215-3216. PubMed: 11591810.
18. Takahashi, S. Vascular endothelial growth factor (VEGF), VEGF receptors and their inhibitors for antiangiogenic tumour therapy. Biol Pharm Bull 2011, 34(12), 1785-1788. doi: 10.1248/bpb.34.1785.
19. Roy, H.; Bhardwaj, S.; Ylä-Herttuala, S. Biology of vascular endothelial growth factors. FEBS letters 2006, 580(12), 2879-2887. doi: 10.1016/j.febslet.2006.03.087.
20. Pentheroudakis, G.; Leonidas Mavroeidis, L.; Papadopoulou, K.; Koliou, G. A.; Bamia, C.; Chatzopoulos, K.; Samantas, E.; Mauri, D.; Efstratiou, I.; Pectasides, D. et al. Angiogenic and anti-angiogenic VEGFA splice variants in colorectal cancer: A prospective retrospective cohort study in patients treated with irinotecan-based chemotherapy and bevacizumab. Clinical Colorectal Cancer. Clinical Colorectal cancer 2019 (In Press- Available online). doi: 10.1016/j.clcc.2019.07.007.
21. Schomber, T.; Zumsteg, A.; Strittmatter. K.; Crnic, I.; Antoniadis, H.; Littlewood-Evans, A.; Wood, J.; Christofori, G. Differential effects of the vascular endothelial growth factor receptor inhibitor PTK787/ZK222584 on tumour angiogenesis and tumour lymphangiogenesis. Mol Cancer Ther 2009, 8(1), 55-63. doi: 10.1158/1535-7163.MCT-08-0679.
22. Tonini, T.; Rossi, F.; Claudio, P. P. Molecular basis of angiogenesis and cancer. Oncogene 2003, 22(42), 6549-6556. Doi: 10.1038/sj.onc.1206816.
23. Koukourakis, M. I.; Papazoglou, D.; Giatromanolaki, A.; Bougioukas, G.; Maltezos, E.; Siviridisc, E. VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer. Lung Cancer 2004, 46(3), 293-298. Doi: 10.1016/j.lungcan.2004.04.037.
24. Kim, Y. H.; Kim, M. A.; Park, I. A.; Park, W. Y.; Kim, J. W.; Kim, S. C.; Parka, N. H.; Song, Y. S.; Kang, S. B. VEGF polymorphisms in early cervical cancer susceptibility, angiogenesis, and survival. Gynecologic oncology 2010, 119(2), 232-236. doi: 10.1016/j.ygyno.2010.07.035.
25. Supic, G.; Jovic, N.; Zeljic, K.; Kozomara, R.; Magic, Z. Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients. Oral oncology 2012, 48(11), 1171-1177.
26. Jannuzzi, A.T.; Özhan, G.; Yanar, H. T. Alpertunga B VEGF Gene Polymorphisms and Susceptibility to Colorectal Cancer. Genetic testing and molecular biomarkers 2015, 19(3), 133-137. doi: 10.1089/gtmb.2014.0259.
27. Spielmann, M.; Lupiáñez, D. G.; Mundlos, S. Structural variation in the 3D genome. Nat Rev Genet 2018, 19(7), 453-467. Doi: 10.1038/s41576-018-0007-0.
28. Vannitamby, A.; Hendry, S.; Makadia, T.; Danks, J.; Slavin, J.; Irving, L.; Steinfort, D.; Bozinovski, S. A Novel Approach to Detect Programed Death Ligand 1 (PD-L1) Status and Multiple Tumor Mutations Using a Single Non–Small-Cell Lung Cancer (NSCLC) Bronchoscopy Specimen. The Journal of Molecular Diagnostics 2019, 21:2, 186-197. Doi: 10.1016/j.jmoldx.2018.10.001.
29. Joshi MS, Berger PJ, Kaye DM, Pearson JT, Bauer JA, Ritchie, R. H. Functional relevance of genetic variations of endothelial nitric oxide synthase and vascular endothelial growth factor in diabetic coronary microvessel dysfunction. Clin Exp Pharmacol Physiol 2013, 40(4), 253-261. doi: 10.1111/1440-1681.12070.
30. Cao, C.; Ying, T.; Fang, J. J.; Sun, S. F.; Lv, D.; Zhong-Bo Chen, Z. B.; Ma, H. Y.; Yu, Y. M.; Ding, O. L.; Shu, l. H.; et al. Polymorphism of vascular endothelial growth factor -2578C/A with cancer risk: evidence from 11263 subjects. Medical Oncology 2011, 28(4), 1169-1175. doi: 10.1007/s12032-010-9613-1.
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