Gastric Hepatoid Adenocarcinoma with multiple liver metastasis. A case report
Gastroenterology and Hepatology from Bed to Bench,
26 April 2021
Hepatoid adenocarcinoma is a poorly differentiated alpha-fetoprotein-producing (AFP) tumor, frequently located in the stomach, ovary, and pancreas. Presentation in the stomach has a high mortality rate due to late diagnosis, which offers the patient little therapeutic alternative. A 44-year-old woman from Lima, on February 22, 2019, entered the emergency department for pain in the right hypochondrium for 4 months, weight loss, nausea and asthenia. On physical examination, hepatomegaly presented with liver span of 17cm. Serology showed severe anemia and AFP of 49800. The tomography showed multiple hypodense lesions in the liver and the presence of nodes. Endoscopy showed Bormann III gastric malignancy. Gastric biopsy determined undifferentiated epithelial malignancy, the immunohistochemical mark (+) for AFP and PAS Diastase confirmed a hepatoid gastric adenocarcinoma. A rare variant of gastric adenocarcinoma is evident, which often mimics an HCC. In this case, multiple liver metastases are observed that differ from the diagnosis of HCC, so this variant must always be taken into account when a primary gastric tumor presents with hepatic metastases.
Keywords: Hepatoid Adenocarcinoma, metastases, liver
- Hepatoid Adenocarcinoma, metastases, liver
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