The association between food insulin index and odds of non-alcoholic fatty liver disease (NAFLD) in adults: a case-control study
Gastroenterology and Hepatology from Bed to Bench,
26 April 2021
Aim: This research aimed to study the association of food insulin index and biochemical parameters with the odds of developing NAFLD in adult Iranians.
Background: Hyperinsulinemia may play an important role in the development of non-alcoholic fatty liver disease (NAFLD) because of the relationship between insulin response and body fat accumulation.
Methods: A case-control study of 169 NAFLD patients and 200 healthy adults aged 18-55 years was conducted. Dietary data was collected using a validated 168-item quantitative food frequency questionnaire (FFQ). Food insulin index (FII) was calculated by dividing the total insulin load by total energy intake (kcal/day). Total insulin load (ILoverall) was also calculated using a standard formula.
Results: Mean participant age was 43.9 ± 5.9 years. Patients with NAFLD were significantly associated with higher body mass index, levels of liver enzymes, triglyceride, low density lipoprotein-cholesterol (LDL), total cholesterol, and fasting blood sugar (FBS) compared to the healthy subjects (p < 0.05). The highest tertiles of FII were associated with higher odds of NAFLD (OR=1.4, 95% CI: 0.88-2.48, p for trend <0.001) and obesity (OR=2.33, 95% CI: 0.97-5.75) compared to the lowest tertiles. Potential confounders for the association were controlled.
Conclusion: This study found that adherence to a diet with high FII was associated with greater odds of NAFLD and overweight or obesity. Additional studies are required to better understand this association.
Keywords: Insulin, Biochemical processes, Obesity, Chronic diseases, Non-alcoholic fatty liver disease.
(Please cite as: Fatahi S, Sohouli MH, Rayi A, Teymoori F, Shidfar F. The association between food insulin index and odds of non-alcoholic fatty liver disease (NAFLD) in adults: a case-control study. Gastroenterol Hepatol Bed Bench 2021;14(3):221-228).
- Insulin; Biochemical Processes; Obesity; Chronic Diseases; Non-alcoholic Fatty Liver Disease
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