Presentation of COVID-19 in a liver transplant recipient
Gastroenterology and Hepatology from Bed to Bench,
20 September 2020
Diarrhea is common after liver transplant. Although the majority of the episodes are experienced during the first year of transplantation, but some of them can be seen at any time after the procedure. Diarrhea can impose a major risk of morbidity and mortality on transplanted patients; so a careful evaluation is required to manage it. There are few studies highlighting the gastrointestinal manifestations of COVID-19, in particular among immunosuppressed patients. Predominant respiratory symptoms of coronavirus is the reason why GI aspects of the virus are usually overlooked. This study represents a young woman with a history of liver transplant who was referred to the hospital because of diarrhea, fever and abdominal pain attributed to coronavirus infection.
- Liver transplant
2. Altiparmak MR, Trablus S, Pamuk ON, Apaydin S, Sariyar M, Ozturk R, et al. Diarrhoea following renal transplantation. ClinTransplant 2002;16:212-216.
3. Wong NA, Bathgate AJ, Bellamy CO. Colorectal disease Eur J Gastroenterol Hepatol 2002;14:231-236.
4. Willingham FF, Ticona CE, Taylor DN, Bowen AB, Crane AR, Gottlieb AL, et al. Diarrhea and Clostridium difficile infection in Latin American patients with AIDS. Working Group on AIDS in Peru. Clin Infect Dis 1998;27:487-493.
5. Philip M. Ginsburg and Paul J. Thuluvath. Diarrhea in Liver Transplant Recipients: Etiology and Management. Liver Transplantation, Vol 11, No 8 (August), 2005:881-890.
6. Alexander JA, Cuellar RE, Fadden RJ, Genovese JJ, Gavaler JS,Van Thiel DH. Cytomegalovirus infection of the upper gastrointestinal tract before and after liver transplantation. Transplantation 1988;46:378-382.
7. Van Thiel DH, Gavaler JS, Schade RR, Chien MC, Starzl TE. Cytomegalovirus infection and gastric emptying. Transplantation 1992;54:70-73.
8. Palau LA, Kemmerly SA. First report of invasive amebiasis in an organ transplant recipient. Transplantation 1997;64:936-937.
9. Mack DR, Dhawan A, Kaufman SS, Langnas AN, Seemayer TA. Small bowel bacterial overgrowth as a cause of chronic diarrhea after liver transplantation in children. Liver Transpl Surg 1998;4:166-169
10. Maes BD, Dalle I, Geboes K, Oellerich M, Armstrong VW, Evenepoel P, et al. Erosive enterocolitis in mycophenolate mofetil-treated renal-transplant recipients with persistent afebrile diarrhea. Transplantation 2003;75:665-672.
11. Maes BD, Lemahieu W, Kuypers D, Evenepoel P, Coosemans W, Pirenne J, et al. Differential effect of diarrhea on FK506 versus cyclosporine A trough levels and resultant prevention of allograft rejection in renal transplant recipients. Am J Transplant 2002;2:989-992.
12. Teisseyre J, Teisseyre M, Kalicinski P, Ismail H, Drewniak T, Kaminski A, et al. Elevated tacrolimus levels during diarrhea in children after liver transplantation. Transplant Proc 2003;35:2292-2294.
13. Smith DM, Agura E, Netto G, Collins R, Levy M, Goldstein R, et al. Liver transplant-associated graft-versus-host disease. Transplantation 2003;75:118-126.
14. Jain A, Nalesnik M, Reyes J, Pokharna R, Mazariegos G, Green M, et al. Posttransplant lymphoproliferative disorders in liver transplantation: a 20-year experience. Ann Surg 2002;236:429-436
15. Dvorchik I, Subotin M, Demetris AJ, Fung JJ, Starzl TE, Wie and S, et al. Effect of liver transplantation on inflammatory bowel disease in patients with primary sclerosing cholangitis. Hepatology 2002;35:380-384.
16. Atassi T, Thuluvath PJ. Risk of colorectal adenoma in liver transplant recipients compared to immunocompetent control population undergoing routine screening colonoscopy. J Clin Gastroenterol 2003;37:72-73.
17. Pan L, Mu M, Yang P, Sun Y, Wang R, Yan J, et al. Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study. Am J Gastroenterol. 2020;115(5):766-73.
18. Tian Y, Rong L, Nian W, He Y. gastrointestinal features in COVID‐19 and the possibility of faecal transmission. Aliment Pharmacol Ther. 2020;51(9):843-51.
19. Jin X, Lian JS, Hu JH, Gao J, Zheng L, Zhang YM, et al. Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut. 2020;69(6):1002-9.
20. Tian Y, Rong L, Nian W, He Y. gastrointestinal features in COVID‐19 and the possibility of faecal transmission. Aliment Pharmacol Ther. 2020;51(9):843-51.
21. Charles J. Kahi et al. Gastrointestinal aspects of COVID-19. NEJM 2020 reviewing Cheung KS et al. Gastroenterology 2020.03.065.
22. Romanelli A, Mascolo S. Immunosuppression drug‐related and clinical manifestation of Coronavirus disease 2019: a therapeutical hypothesis. Am J Transplant. 2020.
- Abstract Viewed: 0 times
- PDF Downloaded: 0 times