Coronavirus disease 2019 (COVID-19) and pediatric gastroenterology COVID-19 and Pediatric Gastroenterology
Gastroenterology and Hepatology from Bed to Bench,
20 September 2020
The coronavirus disease 2019 (COVID-19) is responsible for the new pandemic which remains as an important health and economic challenge in the world wild. The causative agent is a novel coronavirus, called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with similarity to SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Adult infection with symptoms of respiratory tract were considered in the beginning of pandemic. Now, it has been reported that SARS-CoV-2 infects children and another organ such as gastrointestinal tract. SARS-CoV-2 enters the host cells through angiotensin converting enzyme-2 (ACE2) receptors as main receptor which is expressed in the various organs such as lungs and gastrointestinal tract. Studies about children and clinical manifestations of COVID-19 do not completely explain the natural course of infection in children and understanding how GI tract is precisely involved. The present article highlights the gastrointestinal manifestations and pathological findings of children with COVID-19. According to evidence, children with SARS-CoV-2 infection is milder and may present different clinical symptoms from adults. common clinical manifestation of pediatric COVID-19 includes cough, fever, sore throat, malaise, fatigue and GI symptoms like diarrhea, abdominal pain, nausea, vomiting. Furthermore, liver and pancreatic enzymes may be elevated during the pediatric COVID-19 course. Asymptomatic children carriers are potential source of infection for adult especially old one. Diagnosis, treatment and isolation of children are one of the most effective ways to control expansion of pandemic of COVID-19.
- SARS-CoV-2, Pediatric COVID-19 and Gastroenterology
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