The potential of endoscopic ultrasound sonography (EUS)-elastography in determination the stage of pancreatic tumour
Gastroenterology and Hepatology from Bed to Bench,
26 April 2021
Background: Pancreatic cancer is numbered as one of the lethal malignancy with only 5% survival, worldwide. pancreatic lesions include wide ranges of diagnosis from benign to malignant forms. Biopsy and pathological study is the gold standard for differentiation of the malignant lesions and staging of these tumors. Recently, Endoscopic Ultrasound Sonography (EUS) elastography has been noticed as a non-invasive diagnosis modality. Nevertheless, no evidence is available about its potential to determine different stages of malignant tumors. Herein, we designed this study to evaluate the role of semi-quantitative EUS- elastography (strain ratio) in staging the malignant pancreatic lesions.
Method: In this prospective study, 81 adult patients with a confirmed diagnosis of the malignant pancreatic lesion in different clarified stages were included. All the diagnosis was confirmed after endoscopic ultrasound sonography via pathological investigation of surgical specimens or needle biopsies. The results of EUS-elastography based on tumor size (T staging), involved lymph nodes (N staging) and metastasis (M staging) compared with the gold standard.
Results: the mean age of patients was 60.11±13.57 years old. The mean of SR elastography was 52.78±48.97. elastography could not significantly discriminate T stage, N stage, M stage of tumors (P=0.57, P=0.92, P=0.11). in addition, the spearman rank correlation coefficient between T staging, N staging, M staging with SR elastography were not significant (P=0.40, P=0.94, P=0.39).
Conclusion: The EUS-elastography as a non-invasive modality could not replace the gold standard in staging the tumors. But, it seems, EUS-elastography could differentiation benign lesions from malignant type.
Keyword: Pancreatic Neoplasms, Elasticity Imaging Techniques, Neoplasm Staging
- Pancreatic Neoplasms
- Elasticity Imaging Techniques
- Neoplasm Staging
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