COVID-19 prognosis: what we know of the significance and prognostic value of liver-related laboratory parameters in SARS-CoV-2 infection?
Gastroenterology and Hepatology from Bed to Bench,
20 September 2020
This is not the first nor it will be the last time that a member of ?-coronaviruses is waging a full-scale war against human health. Notwithstanding atypical pneumonia being the primary symptom, emergence of severe disease mainly resulting from the injury of non-pulmonary organs leaves no choice, in some cases, rather than a dreadful death. To provide a well-conceptualized viewpoint representing prognostic values of liver-related laboratory parameters in COVID-19, we planned to perform a meta-analysis of pertinent literature. While severe COVID-19 cases displayed higher values of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (Bili) compared to non-severe patients (mean differences of 7.48, 12.07, 3.07), value of albumin (Alb) was significantly lower in severe cases (mean differences of -6.15). There was also correlation between alterations of all these parameters, however, only correlations between ALT and Bili (R=0.98, P=0.0031), and Bili and Alb (R=-1, P=0.0012) were significant. In conclusion, the present study highlighted that abnormal values of liver-related examinations outwardly contribute to reflect progression of the disease toward an unfavorable outcome and therefore, careful scrutiny of these parameters will provide clinicians with invaluable information in SARS-CoV-2 infection, at least in term of liver injury. Even though, at the time of writing this article, the lack of adequate and appropriate studies is the most challenging issue facing us, planning of future research aiming to provide new clues and data will definitively cast a flash of light on the significance of these parameters.
- Liver injury
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