Does the prognosis of colorectal cancer vary with tumor site?
Gastroenterology and Hepatology from Bed to Bench,
Vol. 4 No. 4 (2011),
28 September 2011
Aim: The aim of this study was to compare prognostic factors between colon and rectal cancers.
Background: Prognosis of Colorectal Cancer (CRC) may depend on the anatomical site.
Patients and methods: A total of 1219 patients with CRC diagnosis according to the pathology report of RCGLD cancer registry, from 1 January 2002 to 1 October 2007, were entered into the study. Demographic and clinico-pathological factors were analyzed using survival analysis.
Results: From age at diagnosis, colon cancer had significantly better survival than rectal cancer (Multivariate Hazard Ratio (MVHR)=0.24; 95% Confidence Interval (CI) =(0.074-0.77)). Other factors, including marital status (MVHR =1.78; 95% CI =(0.33-9.62)), body mass index (BMI) (MVHR =1.21 and 1.54; 95% CI =(.30-4.85) and (.44-5.4) respectively for < 18.5 and >30 BMI groups), pathologic stage (MVHR =.64; 95% CI =(.21-1.98)) and alcohol history (MVHR =4.86; 95% CI =(.67-35.14)) were not significantly different between the two patient group but suggested a possible effect upon prognosis. Overall survival in rectum was better than that of colon.
Conclusion: Our findings support this hypothesis that prognosis of CRC varies with tumor site.
- Prognostic factors
- Colorectal cancer
- Survival analysis
- Abstract Viewed: 222 times
- PDF Downloaded: 109 times