Impact of proteomics investigations on gastric cancer treatment and diagnosis
Gastroenterology and Hepatology from Bed to Bench,
Vol. 12 No. Supplement 1 (2019),
7 December 2019
,
Page 1-7
https://doi.org/10.22037/ghfbb.v12i0.1839
Abstract
Gastric cancer is one of the epidemics diseases with a high mortality rate in different countries. It causes many health problems in the world every year. It affects the digestive tract, and in advanced cases, its treatment has many difficulties. Early detection of cancer in different parts of the gastrointestinal tract can be accompanied by inexpensive treatment. As cancer cells make different biomarkers during different stages of the disease, researchers are looking for different biomarkers for gastrointestinal cancers detection. On the other hand, with the advent of advanced techniques such as proteomics and the discovery of a large number of proteins related to gastrointestinal cancer, finding the role of these proteins is essential. Indeed, the function of large amounts of these proteins has remained unknown.
Data from databases such as genes and proteins associated with gastrointestinal cancers were collected and the proteomic data of these databases were analyzed to find a clear perspective of the impact of proteomics in gastric cancer management.
The role of heat shock proteins, metabolic proteins, membrane binding proteins, galectins, prohibitins, S100 proteins, and many different types of proteins in gastric cancer was highlighted. This article reviewed proteomic researches in cancer-related areas of the gastric cancer in order to evaluate the findings of researchers.
Keywords: Gastric cancer, Biomarker, Proteomic.
(Please cite as: Rostami-Nejad M, Rezaei-Tavirani M, Mansouri V, Akbari Z, Abdi S. Impact of proteomics investigations on gastric cancer treatment and diagnosis. Gastroenterol Hepatol Bed Bench 2019;12(Suppl. 1):S1-S7).
- Gastric cancer
- Biomarker
- Proteomic.
How to Cite
References
Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. A Cancer J Clin 2015;65:87-108.
Sitarz R, Skierucha M, Mielko J, Offerhaus GJA, Maciejewski R, Polkowski WP. Gastric cancer: epidemiology, prevention, classification, and treatment. Cancer Manage Res 2018;10:239.
Skierucha M, Milne AN, Offerhaus GJA, Polkowski WP, Maciejewski R, Sitarz R. Molecular alterations in gastric cancer with special reference to the early-onset subtype. World Gastroenterol 2016;22:2460.
Wu W, Yong WW, Chung MC. A simple biomarker scoring matrix for early gastric cancer detection. Proteomics 2016;16:2921-30.
Pan S, Brentnall TA, Kelly K, Chen R. Tissue proteomics in pancreatic cancer study: discovery, emerging technologies, and challenges. Proteomics 2013;13:710-21.
Werner S, Chen H, Tao S, Brenner H. Systematic review: serum autoantibodies in the early detection of gastric cancer. Int J Cancer 2015;136:2243-52.
Catenacci DV, Liao WL, Zhao L, Whitcomb E, Henderson L, O’Day E, et al. Mass-spectrometry-based quantitation of Her2 in gastroesophageal tumor tissue: comparison to IHC and FISH. Gastric Cancer 2016;19:1066-79.
Toiyama Y, Okugawa Y, Goel A. DNA methylation and microRNA biomarkers for noninvasive detection of gastric and colorectal cancer. Biochem Biophys Res Commun 2014;455:43-57.
Liu R, Zhang C, Hu Z, Li G, Wang C, Yang C, et al. A five-microRNA signature identified from genome-wide serum microRNA expression profiling serves as a fingerprint for gastric cancer diagnosis. Eur J Cancer 2011;47:784-91.
Xiao H, Zhang Y, Kim Y, Kim S, Kim JJ, Kim KM, et al. Differential Proteomic Analysis of Human Saliva using Tandem Mass Tags Quantification for Gastric Cancer Detection. Sci Rep 2016;6:22165.
Hu W, Wang J, Luo G, Luo B, Wu C, Wang W, et al. Proteomics-based analysis of differentially expressed proteins in the CXCR1-knockdown gastric carcinoma MKN45 cell line and its parental cell. Acta Biochim Biophys Sin 2013;45:857-66.
Leal MF, Wisnieski F, de Oliveira Gigek C, Do Santos LC, Calcagno DQ, Burbano RR, et al. What gastric cancer proteomic studies show about gastric carcinogenesis? Tumor Biol 2016;37:9991-10010.
Yang J, Xiong X, Wang X, Guo B, He K, Huang C. Identification of peptide regions of SERPINA1 and ENOSF1 and their protein expression as potential serum biomarkers for gastric cancer. Tumour Biol 2015;36:5109-18.
Ryu JW, Kim HJ, Lee YS, Myong NH, Hwang CH, Lee GS, et al. The proteomics approach to find biomarkers in gastric cancer. J Korean Med Sci 2003;18:505.
Cai Z, Zhao JS, Li JJ, Peng DN, Wang XY, Chen TL, et al. A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism. Mol Cell Proteomics 2010;9:2617-28.
Leal MF, Chung J, Calcagno DQ, Assumpcao PP, Demachki S, da Silva IDCG, et al. Differential proteomic analysis of noncardia gastric cancer from individuals of northern Brazil. PLoS One 2012;7:e42255.
Kočevar N, Odreman F, Vindigni A, Grazio SF, Komel R. Proteomic analysis of gastric cancer and immunoblot validation of potential biomarkers. World J Gastroenterol 2012;18:1216.
Wu C, Luo Z, Chen X, Wu C, Yao D, Zhao P, et al. Two-dimensional differential in-gel electrophoresis for identification of gastric cancer-specific protein markers. Oncol Rep 2009;21:1429-37.
Cheng Y, Zhang J, Li Y, Wang Y, Gong J. Proteome analysis of human gastric cardia adenocarcinoma by laser capture microdissection. BMC Cancer 2007;7:191.
Chen J, Kähne T, Röcken C, Götze T, Yu J, Sung JJ, et al. Proteome analysis of gastric cancer metastasis by two-dimensional gel electrophoresis and matrix assisted laser desorption/ionization-mass spectrometry for identification of metastasis-related proteins. J Proteome Res 2004;3:1009-16.
Chen YR, Juan HF, Huang HC, Huang HH, Lee YJ, Liao MY, et al. Quantitative proteomic and genomic profiling reveals metastasis-related protein expression patterns in gastric cancer cells. J Proteome Res 2006;5:2727-42.
Nakatsura T, Senju S, Yamada K, Jotsuka T, Ogawa M, Nishimura Y. Gene cloning of immunogenic antigens overexpressed in pancreatic cancer. Biochemical and biophysical research communications. 2001;281(4):936-44.
Lianos GD, Alexiou GA, Mangano A, Mangano A, Rausei S, Boni L, et al. The role of heat shock proteins in cancer. Cancer lett 2015;360:114-8.
Hou Q, Tan HT, Lim KH, Lim TK, Khoo A, Tan IB, et al. Identification and functional validation of caldesmon as a potential gastric cancer metastasis-associated protein. J Proteome Res 2013;12:980-90.
Kapranos N, Kominea A, Konstantinopoulos P, Savva S, Artelaris S, Vandoros G, et al. Expression of the 27-kDa heat shock protein (HSP27) in gastric carcinomas and adjacent normal, metaplastic, and dysplastic gastric mucosa, and its prognostic significance. J Cancer Res Clin Oncol 2002;128:426-32.
Liu H, Lu J, Hua Y, Zhang P, Liang Z, Ruan L, et al. Targeting heat-shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancer. Cell Death Dis 2015;6:e1595.
Banerji U. O7. 6HSP90 inhibitors in the clinic. Ann Oncol 2015;26.
Capello M, Ferri-Borgogno S, Cappello P, Novelli F. α‐enolase: a promising therapeutic and diagnostic tumor target. FEBS J 2011;278:1064-74.
Bai Z, Ye Y, Liang B, Xu F, Zhang H, Zhang Y, et al. Proteomics-based identification of a group of apoptosis-related proteins and biomarkers in gastric cancer. Int J Oncol 2011;38:375-83.
Yan GR, Xu SH, Tan ZL, Yin XF, He QY. Proteomics characterization of gastrokine 1‐induced growth inhibition of gastric cancer cells. Proteomics 2011;11:3657-64.
Pancholi V. Multifunctional α-enolase: its role in diseases. Cell Mol Life Sci 2001;58:902-20.
Kočevar N, Grazio SF, Komel R. Two-dimensional gel electrophoresis of gastric tissue in an alkaline p H range. Proteomics 2014;14:311-21.
Goh WQJ, Ow GS, Kuznetsov VA, Chong S, Lim YP. DLAT subunit of the pyruvate dehydrogenase complex is upregulated in gastric cancer-implications in cancer therapy. Am J Trans Res 2015;7:1140.
House SW, Warburg O, Burk D, Schade AL. On respiratory impairment in cancer cells. Science 1956;124:267-72.
Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 2004;4:891.
DeBerardinis RJ, Sayed N, Ditsworth D, Thompson CB. Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev 2008;18:54-61.
Gerke V, Creutz CE, Moss SE. Annexins: linking Ca 2+ signalling to membrane dynamics. Nat Rev Mol Cell Biol 2005;6:449.
Liu R, Li Z, Bai S, Zhang H, Tang M, Lei Y, et al. Mechanism of cancer cell adaptation to metabolic stress: proteomics identification of a novel thyroid hormone-mediated gastric carcinogenic signaling pathway. Mol Cell Proteomics 2009;8:70-85.
Leal MF, Calcagno DQ, Chung J, de Freitas VM, Demachki S, Assumpção PP, et al. Deregulated expression of annexin-A2 and galectin-3 is associated with metastasis in gastric cancer patients. Clin Exp Med 2015;15:415-20.
Emoto K, Sawada H, Yamada Y, Fujimoto H, Takahama Y, Ueno M, et al. Annexin II overexpression is correlated with poor prognosis in human gastric carcinoma. Anticancer Res 2001;21:1339-45.
Sun M-Y, Xing R-H, Gao X-J, Yu X, He H-M, Gao N, et al. ANXA2 regulates the behavior of SGC-7901 cells. Asian Pac J Cancer Prev 2013;14:6007-12.
Zhu F, Xu C, Jiang Z, Jin M, Wang L, Zeng S, et al. Nuclear localization of annexin A1 correlates with advanced disease and peritoneal dissemination in patients with gastric carcinoma. Anat Rec 2010;293:1310-4.
Cheng TY, Wu MS, Lin JT, Lin MT, Shun CT, Huang HY, et al. Annexin A1 is associated with gastric cancer survival and promotes gastric cancer cell invasiveness through the formyl peptide receptor/extracellular signal‐regulated kinase/integrin beta‐1‐binding protein 1 pathway. Cancer 2012;118:5757-67.
Jorge YC, Mataruco MM, Araújo LP, Rossi AFT, De Oliveira JG, Valsechi MC, et al. Expression of annexin-A1 and galectin-1 anti-inflammatory proteins and mRNA in chronic gastritis and gastric cancer. Mediators Inflammation 2013;2013.
Kikuchi S, Kaibe N, Morimoto K, Fukui H, Niwa H, Maeyama Y, et al. Overexpression of Ephrin A2 receptors in cancer stromal cells is a prognostic factor for the relapse of gastric cancer. Gastric cancer 2015;18:485-94.
Zhang ZQ, Li XJ, Liu GT, Xia Y, Zhang XY, Wen H. Identification of Annexin A1 protein expression in human gastric adenocarcinoma using proteomics and tissue microarray. World J Gastroenterol 2013;19:7795.
Gao W, Xu J, Wang F, Zhang L, Peng R, Shu Y, et al. Plasma membrane proteomic analysis of human Gastric Cancer tissues: revealing flotillin 1 as a marker for Gastric Cancer. BMC Cancer 2015;15:367.
Yu S, Li Y, Fan L, Zhao Q, Tan B, Liu Y. Impact of Annexin A3 expression in gastric cancer cells. Neoplasma 2014;61:257-64.
Wang X, Zhang S, Zhang J, Lam E, Liu X, Sun J, et al. Annexin A6 is down-regulated through promoter methylation in gastric cancer. Am J Transl Res 2013;5:555.
Hsu PI, Huang MS, Chen HC, Hsu PN, Lai TC, Wang JL, et al. The significance of ANXA7 expression and its correlation with poor cellular differentiation and enhanced metastatic potential of gastric cancer. J Surg Oncol 2008;97:609-14.
Kim J, Kim MA, Jee CD, Jung EJ, Kim WH. Reduced expression and homozygous deletion of annexin A10 in gastric carcinoma. Int J Cancer 2009;125:1842-50.
Lu SH, Chen YL, Shun CT, Lai JN, Peng SY, Lai PL, et al. Expression and prognostic significance of gastric‐specific annexin A10 in diffuse‐and intestinal‐type gastric carcinoma. J Gastroenterol Hepatol 2011;26:90-7.
Thijssen VL, Heusschen R, Caers J, Griffioen AW. Galectin expression in cancer diagnosis and prognosis: A systematic review. Biochim Biophys Acta 2015;1855:235-47.
Bektas S, Bahadir B, Ucan BH, Ozdamar SO. CD24 and galectin-1 expressions in gastric adenocarcinoma and clinicopathologic significance. Pathol Oncol Res 2010;16:569-77.
Chen J, Tang D, Wang S, Li QG, Zhang JR, Li P, et al. High expressions of galectin-1 and VEGF are associated with poor prognosis in gastric cancer patients. Tumor Biol 2014;35:2513-9.
Jung JH, Kim HJ, Yeom J, Yoo C, Shin J, Yoo J, et al. Lowered expression of galectin-2 is associated with lymph node metastasis in gastric cancer. J Gastroenterol 2012;47:37-48.
Ellerhorst J, Troncoso P, Xu XC, Lee J, Lotan R. Galectin-1 and galectin-3 expression in human prostate tissue and prostate cancer. Urol Res 1999;27:362-7.
Van den Brule F, Berchuck A, Bast R, Liu FT, Gillet C, Sobel M, et al. Differential expression of the 67-kD laminin receptor and 31-kD human laminin-binding protein in human ovarian carcinomas. Eur J Cancer 1994;30:1096-9.
Choufani G, Nagy N, Saussez S, Marchant H, Bisschop P, Burchert M, et al. The levels of expression of galectin‐1, galectin‐3, and the Thomsen–Friedenreich antigen and their binding sites decrease as clinical aggressiveness increases in head and neck cancers. Cancer 1999;86:2353-63.
Martínez-Aguilar J, Clifton-Bligh R, Molloy MP. A multiplexed, targeted mass spectrometry assay of the S100 protein family uncovers the isoform-specific expression in thyroid tumours. BMC Cancer 2015;15:199.
Moss SE, Morgan RO. The annexins. Genome Biol 2004;5:219.
Liu Y-F, Liu Q-Q, Wang X, Luo C-H. Clinical significance of S100A2 expression in gastric cancer. Tumor Biology. 2014;35(4):3731-41.
Kang X, Zhang L, Sun J, Ni Z, Ma Y, Chen X, et al. Prohibitin: a potential biomarker for tissue-based detection of gastric cancer. J Gastroenterol 2008;43:618-25.
Liu T, Tang H, Lang Y, Liu M, Li X. MicroRNA-27a functions as an oncogene in gastric adenocarcinoma by targeting prohibitin. Cancer lett 2009;273:233-42.
Leal MF, Cirilo PDR, Mazzotti TKF, Calcagno DQ, Wisnieski F, Demachki S, et al. Prohibitin expression deregulation in gastric cancer is associated with the 3′ untranslated region 1630 C> T polymorphism and copy number variation. PLoS One 2014;9:e98583.
Balluff B, Rauser S, Meding S, Elsner M, Schöne C, Feuchtinger A, et al. MALDI imaging identifies prognostic seven-protein signature of novel tissue markers in intestinal-type gastric cancer. Am J Pathol 2011;179:2720-9.
Schwamborn K. Imaging mass spectrometry in biomarker discovery and validation. Journal of proteomics. 2012;75(16):4990-8.
Yuan W, Chen Z, Wu S, Ge J, Chang S, Wang X, et al. Expression of EphA2 and E-cadherin in gastric cancer: correlated with tumor progression and lymphogenous metastasis. Pathology & Oncology Research. 2009;15(3):473.
Ichikawa H, Kanda T, Kosugi Si, Kawachi Y, Sasaki H, Wakai T, et al. Laser microdissection and two-dimensional difference gel electrophoresis reveal the role of a novel macrophage-capping protein in lymph node metastasis in gastric cancer. J Proteome Res 2013;12:3780-91.
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