Circulating tumor DNA applications in treatment monitoring of metastatic colorectal cancer patients
Gastroenterology and Hepatology from Bed to Bench,
Vol. 12 No. Supplement 1 (2019),
7 December 2019
,
Page 14-21
https://doi.org/10.22037/ghfbb.v12i0.1812
Abstract
Colorectal cancer is the third most common cancer worldwide. New cancer treatment strategies such as monoclonal antibodies against growth factor and angiogenesis receptors have improved the overall survival (OS) and progression-free survival (PFS) in metastatic colorectal cancer (mCRC) patients. However, acquired resistance could happen after these therapies. Circulating tumor DNA (ctDNA) is the DNA fraction derived from tumor cells which could be applied as a non-invasive method for detecting tumor mutations before, during, and after therapies. Here, we reviewed most of the studies examining ctDNA as treatment monitoring in mCRC patients who receive different target therapies. Also, we compared ctDNA with other existing cancer-treatment monitoring methods.
Keywords: Circulating tumor DNA, Colorectal cancer, Treatment monitoring.
(Please cite as: Kazemifard N, Sadeghi A, Varaminian B, Rezvani H, Ayadi A, Talaie R, et al. Circulating tumor DNA applications in treatment monitoring of metastatic colorectal cancer patients Gastroenterol Hepatol Bed Bench 2019;12(Suppl.1):S14-S21).
- Circulating tumor DNA
- Colorectal cancer
- Treatment monitoring.
How to Cite
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