Protective effects of synbiotic soymilk fortified with whey protein concentrate and zinc sulfate against bile duct ligated induced hepatic encephalopathy
Gastroenterology and Hepatology from Bed to Bench,
Vol. 13 No. 1 (2020),
22 January 2020
,
Page 64-76
https://doi.org/10.22037/ghfbb.v13i1.1750
Abstract
Abstract
Aim(s): Hepatic encephalopathy (HE) is seriously associated with neuromuscular and cognitive alterations. This study aimed to examine the hepato-protective effect of different soymilk products on bile duct ligated induced HE.
Methods: Eighty-two Sprague Dawley rats were randomly assigned into seven groups (Sham, bile duct ligation (BDL), BDL + lactulose, BDL + soymilk (SM), BDL + Synbiotic soymilk (SSM), BDL + SSM + whey protein concentrate (WPC), BDL + SSM + WPC + ZnSO4). Different SM products, lactulose, and normal saline were given via oral gavage. The serum and liver markers and liver histopathology were assessed at the end of the experiment.
Results: The SM products significantly reduced serum alanine aminotransferase, albumin, and ammonia (P < 0.05). The levels of Aspartate aminotransferase, endotoxin, and liver interleukin-6 were improved significantly in all treatments except for those receiving SM. SSM and SSM + WPC + ZnSO4 were the only effective products in reduction of serum Alkaline phosphatase (P < 0.05). Furthermore, liver total antioxidant capacity level was greater (P < 0.05) in the SSM + WPC and SSM + WPC + ZnSO4 groups. The histopathological examinations confirmed the efficiency of all SM products in the reduction of the liver fibrosis. Liver bile duct proliferation was reduced only in the SSM + WPC and SSM + WPC+ ZnSO4 groups (P < 0.05).
Conclusion: This study showed positive effects of different SM products, especially SSM + WPC and SSM + WPC + ZnSO4 in HE. Further studies are required to elucidate our findings- Hepatic encephalopathy
- Soymilk
- Synbiotic
- Whey protein
- Zinc sulfate
How to Cite
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