Metabolic analysis of acute appendicitis by using system biology approach
Gastroenterology and Hepatology from Bed to Bench,
Vol. 11 No. Supplement 1 (2018),
11 December 2018
,
Page s92-s97
https://doi.org/10.22037/ghfbb.v0i0.1517
Abstract
Aim: Introducing possible suitable compound as diagnostic agent in appendicitis is aim of this investigation.
Background: Appendicitis diagnosis is a difficult step in treatment of disease due to complex abdominal pain signal which may be refer to the non-appendicitis pain.
Methods: Gene expression profiles of children with non-preforated appendicitis in comparison with the samples with non- appendicitis abdominal pain are analysis via protein – protein interaction (PPI) and the critical compounds are introduced by STITCH.
Results: Ten compounds including including MgATP, glycerol, MgADP, calcium ions, chloride, magnesium, phosphate, sulphate, acetate, and sodium are introduced as possible biomarker panel to differentiate appendicitis from the other abdominal pains.
Conclusion: A laboratory method such as flame photometry based on metal detection for diagnosis of appendicitis is possible, however more investigations are required.
Keywords: Appendicitis, Gene, Biomarker.
(Please cite as: Zojaji H, Rezaei Tavirani M, Mansouri V, Seyed Salehi A, Robati RM, Lak E. Metabolic analysis of acute appendicitis by using system biology approach. Gastroenterol Hepatol Bed Bench 2018;11(Suppl. 1):S92-S97).
- Appendicitis
- Gene
- Biomarker.
How to Cite
References
Bhangu A, Søreide K, Di Saverio S, Assarsson JH, Drake FT. Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet 2015;386:1278-87.
Alvarado A. How to improve the clinical diagnosis of acute appendicitis in resource limited settings. World J Emerg Surg 2016;11:16.
Mathews EK, Griffin RL, Mortellaro V, Beierle EA, Harmon CM, Chen MK, et al. Utility of immature granulocyte percentage in pediatric appendicitis. J Surg
Res 2014;190:230-4.
Kentsis A, Lin YY, Kurek K, Calicchio M, Wang YY, Monigatti F, et al. Discovery and validation of urine markers of acute pediatric appendicitis using high-accuracy mass spectrometry. Ann Emerg Med 2010;55:62-70.
Chawla LS, Toma I, Davison D, Vaziri K, Lee J, Lucas R, et al. Acute appendicitis: transcript profiling of blood identifies promising biomarkers and potential underlying processes. BMC Med Genomics 2016;9:40.
Khayer N, Zamanian-Azodi M, Mansouri V, Ghassemi-Broumand M, Rezaei-Tavirani M, Heidari MH, et al. Oral squamous cell cancer protein-protein interaction network interpretation in comparison to esophageal adenocarcinoma. Gastroenterol Hepatol Bed Bench 2017;10:118-24.
Rezaie-Tavirani M, Fayazfar S, Heydari-Keshel S, Rezaee MB, Zamanian-Azodi M, Rezaei-Tavirani M, et al. Effect of essential oil of Rosa Damascena on human colon cancer cell line SW742. Gastroenterol Hepatol Bed Bench 2013;6:25.
Sharifian A, Pourhoseingholi MA, Emadedin M, Rostami Nejad M, Ashtari S, Hajizadeh N, et al. Burden of Breast Cancer in Iranian Women is Increasing. Asian Pac J Cancer Prev. 2015;16:5049-52.
Nazemalhosseini Mojarad E, Farahani RK, Haghighi MM, Aghdaei HA, Kuppen PJ, Zali MR. Clinical implications of BRAF mutation test in colorectal cancer. Gastroenterol Hepatol Bed Bench. 2013;6:6-13.
Zamanian Azodi M, Rezaei-Tavirani M, Mahboubi M, Hamidpour M, Rezaei Tavirani M, Hamdieh M, et al. Serum Proteomic study of Women with Obsessive-Compulsive Disorder, Washing Subtype. BCN 2018;9:337-46.
Zamanian-Azodi M, Rezaei-Tavirani M, Rahmati-Rad S, Rezaei Tavirani M. Ethanol and Cancer Induce Similar Changes on Protein Expression Pattern of Human Fibroblast Cell. Iran J Pharm Res 2016;15:175-84.
Azodi MZ, Rezaei-Tavirani M, Rezaei-Tavirani M, Mansouri V, Vafaee R. Interpretation of Tongue Squamous Cell Carcinoma via Protein-Protein Interaction Network Construction and Analysis. International Journal of Cancer Management 2018;11.
Kohl M, Wiese S, Warscheid B. Cytoscape: software for visualization and analysis of biological networks. Methods Mol Biol 2011;696:291-303.
Rezaei Tavirani M, OkHOVATIAN F, Zamanian Azodi M, Rezaei Tavirani M. Duchenne Muscular Dystrophy (DMD) Protein-Protein Interaction Mapping. Iran J Child Neurol 2017;11:7-14.
Safaei A, Rezaei Tavirani M, Zamanian Azodi M, Lashay A, Mohammadi SF, Ghasemi Broumand M, et al. Diabetic Retinopathy and Laser Therapy in Rats: A Protein-Protein Interaction Network Analysis. J Lasers Med Sci 2017;8:S20-1.
Zamanian Azodi M, Peyvandi H, Rostami-Nejad M, Safaei A, Rostami K, Vafaee R, et al. Protein-protein interaction network of celiac disease. Gastroenterol Hepatol Bed Bench 2016;9:268-77.
Zamanian Azodi M, Rezaei-Tavirani M, Rostami Nejad M, Rezaei-Tavirani M. Human Prolactinoma: A View of Protein-Protein Interaction Pattern. Int J Endocrinol Metab 2018;16:e67332.
Safaei A, Rezaei Tavirani M, Arefi Oskouei A, Zamanian Azodi M, Mohebbi SR, Nikzamir AR. Protein-protein interaction network analysis of cirrhosis liver disease. Gastroenterol Hepatol Bed Bench 2016;9:114-23.
Zamanian-Azodi M, Rezaei-Tavirani M, Rahmati-Rad S, Hasanzadeh H, Tavirani MR, Seyyedi SS. Protein-Protein Interaction Network could reveal the relationship between the breast and colon cancer. Gastroenterol Hepatol Bed Bench 2015;8:215.
Shommu NS, Jenne CN, Blackwood J, Martin DA, Joffe AR, Eccles R, et al. The Use of Metabolomics and Inflammatory Mediator Profiling Provides a Novel Approach to Identifying Pediatric Appendicitis in the Emergency Department. Sci Rep 2018;8:4083.
Tajbakhsh M, García Migura L, Rahbar M, Svendsen CA, Mohammadzadeh M, et al. Antimicrobial-resistant Shigella infections from Iran: an overlooked problem? J Antimicrob Chemother. 2012;67:1128-33.
Nazemalhosseini Mojarad E, Kuppen PJ, Aghdaei HA, Zali MR. The CpG island methylator phenotype (CIMP) in colorectal cancer. Gastroenterol Hepatol Bed Bench. 201;6:120-8.
Rostami Nejad M, Nazemalhosseini Mojarad E, Nochi Z, Fasihi Harandi M, Cheraghipour K, Mowlavi GR, et al. Echinococcus granulosus strain differentiation in Iran based on sequence heterogeneity in the mitochondrial 12S rRNA gene. J Helminthol. 2008;82:343-47.
Larki P, Gharib E, Yaghoob Taleghani M, Khorshidi F, Nazemalhosseini-Mojarad E, Asadzadeh Aghdaei H. Coexistence of KRAS and BRAF Mutations in Colorectal Cancer: A Case Report Supporting The Concept of Tumoral Heterogeneity. Cell J. 2017;19:113-117.
Aktimur R, Gokakin AK, Deveci K, Atabey M, Topcu O. Oxidative stress markers in laparoscopic vs. open appendectomy for acute appendicitis: A double-blind randomized study. J Minim Access Surg 2016;12:143-7.
Rostami Nejad M, Rostami K, Cheraghipour K, Nazemalhosseini Mojarad E, Volta U, Al Dulaimi D, et al. Celiac disease increases the risk of Toxoplasma gondii infection in a large cohort of pregnant women. Am J Gastroenterol. 2011;106:548-49.
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