Barrett's esophagustransits to a cancer condition via potential biomarkers
Gastroenterology and Hepatology from Bed to Bench,
Vol. 11 No. Supplement 1 (2018),
11 December 2018
,
Page s80-s84
https://doi.org/10.22037/ghfbb.v0i0.1510
Abstract
Aim: In this study, the transcriptome profile of Barrett's esophagus (BE) was examined for identification potential related biomarkers in view of interacting charactering.
Background: Since BE is known as a precursor of esophageal cancer, the molecular studies of this condition could be essential.
Methods: Gene expression data of BE in comparison with normal cases, GSE34619 was retrieved from Gene Expression Omnibus. Differentially expressed genes (DEGs) were determined applying GEO2R online software. The DEGs then were analyzed in terms of centrality properties via constructing an interaction network.
Results: The data indicate that there are two sets of hub-bottlenecks panels with distinguishable values in BE. The first group shows that BE is very susceptible to develop cancer, and the second one implied on central characteristic of some DEGs as previously were also reported for BE pathogenicity. In addition, these genes are also implicated in cancer shift from certain conditions.
Conclusion: On the whole, taking together these findings explain and support the cancerous origin of BE and introduced a panel of nominated biomarkers that could be more specific for BE rather than other types of esophageal problems. However, a complementary study to support this claim is suggested.
Keywords: Barrett's esophagus, Transcriptome, Protein interaction maps, Cancer development.
(Please cite as: Zali MR, Zadeh-Esmaeel MM, Rezaei-Tavirani M, Tabatabaei ES, Ahmadi NA. Barrett's esophagus transits to a cancer condition via potential biomarkers. Gastroenterol Hepatol Bed Bench 2018;11(Suppl. 1):S80-S84).
- Barrett's esophagus
- Transcriptome
- Protein interaction maps
- Cancer development.
How to Cite
References
Larki P, Gharib E, Yaghoob Taleghani M, Khorshidi F, Nazemalhosseini-Mojarad E, Asadzadeh Aghdaei H. Coexistence of KRAS and BRAF Mutations in Colorectal Cancer: A Case Report Supporting The Concept of Tumoral Heterogeneity. Cell J. 2017;19:113-117.
Bus P, Kestens C, Ten Kate FJ, Peters W, Drenth JP, Roodhart JM, et al. Profiling of circulating microRNAs in patients with Barrett's esophagus and esophageal adenocarcinoma. J Gastroenterol 2016;51:560-70.
Contino G, Vaughan TL, Whiteman D, Fitzgerald RC. The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma. Gastroenterology 2017;153:657-73.
Crous-Bou M, Feskanich D, Stampfer MJ, Fuchs CS, De Vivo I, Jacobson BC. Gene-environment interactions and the risk of Barrett's esophagus in three US cohorts. Genetic Epidemiology 2013;37:643-56.
Rostami Nejad M, Nazemalhosseini Mojarad E, Nochi Z, Fasihi Harandi M, Cheraghipour K, Mowlavi GR, et al. Echinococcus granulosus strain differentiation in Iran based on sequence heterogeneity in the mitochondrial 12S rRNA gene. J Helminthol. 2008;82:343-47.
Mansouri V, Rezaei Tavirani S, Zadeh-Esmaeel MM, Rostami-Nejad M, Rezaei-Tavirani M. Comparative study of gastric cancer and chronic gastritis via network analysis. Gastroenterol Hepatol Bed Bench 2018;11:343-51.
Dashatan NA, Tavirani MR, Zali H, Koushki M, Ahmadi N. Prediction of Leishmania Major Key Proteins via Topological Analysis of Protein-Protein Interaction Network. GMJ 2018;7.
Zamanian Azodi M, Peyvandi H, Rostami-Nejad M, Safaei A, Rostami K, Vafaee Ret al. Protein-protein interaction network of celiac disease. Gastroenterol Hepatol Bed Bench. 2016;9:268-277.
Wang C, Yang H, Gao C. Potential biomarkers for heart failure. J Cell Physiol 2018;
Safari-Alighiarloo N, Taghizadeh M, Seyyed Mohammad T, Shahsavari S, Namaki S, Khodakarim S, et al. Topological analysis of blood differentially expressed genes in protein-protein interaction network in type 1 diabetes. Koomesh 2016:86-94.
Deng W, Gu L, Li X, Zheng J, Zhang Y, Duan B, et al. CD24 associates with EGFR and supports EGF/EGFR signaling via RhoA in gastric cancer cells. J Transl Med 2016;14:32.
Valizadeh R, Bahadorimonfared A, Rezaei-Tavirani M, Norouzinia M, Ehsani Ardakani MI. Evaluation of involved proteins in colon adenocarcinoma: an interactome analysis. Gastroenterol Hepatol Bed Bench 2017;10:S129-38.
Reid BJ, Levine DS, Longton G, Blount PL, Rabinovitch PS. Predictors of progression to cancer in Barrett's esophagus: baseline histology and flow cytometry identify low- and high-risk patient subsets. Am J Gastroenterol 2000;95:1669-76.
Nazemalhosseini Mojarad E, Farahani RK, Haghighi MM, Aghdaei HA, Kuppen PJ, Zali MR. Clinical implications of BRAF mutation test in colorectal cancer. Gastroenterol Hepatol Bed Bench. 2013;6:6-13.
Gharahkhani P, Fitzgerald RC, Vaughan TL, Palles C, Gockel I, Tomlinson I, et al. Genome-wide association
studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis. Lancet Oncol 2016 Oct;17:1363-73.
Guo Y, Bao Y, Ma M, Zhang S, Zhang Y, Yuan M, et al. Clinical significance of the correlation between PLCE 1and PRKCA in esophageal inflammation and esophageal carcinoma. Oncotarget. 2017May 16;8:33285-99.
Al-Taie OH, Graf T, Illert B, Katzenberger T, Mörk H, Kraus MR, et al. Differential effects of PPARgamma activation by the oral antidiabetic agent pioglitazone in Barrett's carcinoma in vitro and in vivo. J Gastroenterol 2009;44:919-29.
Verbeke H, Geboes K, Van Damme J, Struyf S. The role of CXC chemokines in the transition of chronic inflammation to esophageal and gastric cancer. Biochim
Biophys Acta 2012;1825:117-29.
Sharifian A, Pourhoseingholi MA, Emadedin M, Rostami Nejad M, Ashtari S, Hajizadeh N, et al. Burden of Breast Cancer in Iranian Women is Increasing. Asian Pac J Cancer Prev. 2015;16:5049-52.
Wasniewski T, Woclawek-Potocka I, Boruszewska D, Kowalczyk-Zieba I, Sinderewicz E, Grycmacher K. The significance of the altered expression of lysophosphatidic acid receptors, autotaxin and phospholipase A2 as the potential
biomarkers in type 1 endometrial cancer biology. Oncol Rep 2015;34:2760-7.
Picardo S, Sommerville G, Maher S, Reynolds J. the Ccl28 chemokine is differentially expressed in response to bile acid across the Barrett's oesophagus to adenocarcinoma sequence: o11. BJS 2011;98:4.
Rostami Nejad M, Rostami K, Cheraghipour K, Nazemalhosseini Mojarad E, Volta U, Al Dulaimi D, et al. Celiac disease increases the risk of Toxoplasma gondii infection in a large cohort of pregnant women. Am J Gastroenterol. 2011;106:548-49.
- Abstract Viewed: 167 times
- PDF Downloaded: 107 times