Restless leg syndrome a common undiagnosed comorbidity of clinical significance in cirrhosis
Gastroenterology and Hepatology from Bed to Bench,
Vol. 12 No. 1 (2019),
29 January 2019
,
Page 13-16
https://doi.org/10.22037/ghfbb.v0i0.1486
Abstract
ABSTRACT
Background & Aim: Sleep disturbances are common in cirrhosis. Restless leg syndrome is a chronic sensorimotor sleep disorder with an irresistible urge to move limbs. Our aim was to study prevalence &association of RLS in liver cirrhosis subjects.
Material & Method: Two hundred consecutive cirrhosis patients, presenting at Mahatma Gandhi Medical College & Hospital, Jaipur were evaluated. 157 subjects meeting the inclusion criteria were selected for further evaluation. Revised International Restless Legs Syndrome Study Group (IRLSSG) criteria 2012, was used for diagnosed of RLS. Severity of RLS was evaluated by a validated Hindi translation of International RLS severity (IRLS) scoring system.
Result: Of studied 157 cirrhotic, the mean age was 46.4 ± 10 years, 109 (69.43%) males and 48 (30.57%) females. 41 (26.11%) cirrhotic subjects had Restless Leg Syndrome (RLS). Child Turcotte Pugh (CTP) Class (A 9/55, B 15/68, C 17/34; p 0.043) and alcohol as etiology for liver dysfunction (p 0.03) was significantly associated with RLS.
Conclusion: RLS is common comorbidity in cirrhosis, especially in alcohol related cirrhosis. RLS has a clinical correlation with prognosis & severity of cirrhosis.
- RLS
- Cirrhosis
- CTP
How to Cite
References
Ekbom KA. Restless legs syndrome. Neurology 1960; 10:868-73.
Allen RP, Earley CJ. Restless legs syndrome: a review of clinical and pathophysiologic features. J Clin Neurophysiol 2001;18:128-47
Svetel MV, Jovic JS, Pekmezovic TD, Kostic VS. Quality of life in patients with primary restless leg syndrome: community-based study. Neurol Sci 2015;36:1345–51
Allen RP, Auerbach S, Bahrain H, Auerbach M, Earley CJ. The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia. Am J Hematol 2013;88:261–4.
Luigetti M, Del Grande A, Testani E, Bisogni G, Losurdo A, Giannantoni NM, et al. Restless leg syndrome in different types of demyelinating neuropathies: a single-center pilot study. J Clin Sleep Med 2013;9:945–9.
Stefanidis I, Vainas A, Dardiotis E, Giannaki CD, Gourli P, Papadopoulou D, ,et al. Restless legs syndrome in hemodialysis patients: an epidemiologic survey in Greece. Sleep Med 2013;14:1381–6.
Rajender A, Gaurav R, Kanwal K, Chaudhri RS, Deepa C, Choudhary P, et al. Restless leg syndrome as co-morbidity in type 2 diabetes mellitus. Int J Adv Med 2016; 3:282-6.
Mostacci B, Ferlisi M, Baldi Antognini A, Sama C, Morelli C, Mondini S, et al. Sleep disturbance and daytime sleepiness in patients with cirrhosis: a case control study. Neurol Sci 2008;29:237-40
Cordoba J, Cabrera J, Lataif L, Penev P, Zee P, Blei AT. High prevalence of sleep disturbance in cirrhosis. Hepatology 1998;27: 339–45
Matsuzaki T, Ichikawa T, Kondo H, Taura N, Miyaaki H, Isomoto H, et al. Prevalence of restless legs syndrome in Japanese patients with chronic liver disease. Hepatol Res 2012;42:1221-6.
Franco RA, Ashwathnarayan R, Deshpandee A, Knox J, Daniel J, Eastwood D, et al. The high prevalence of restless legs syndrome symptoms in liver disease in an academic-based hepatology practice. J Clin Sleep Med 2008;4:45-9.
Gupta R, Lahan V, Goel D. Translation and validation of International Restless Leg Syndrome Study Group rating scale in Hindi language. Ann Indian AcadNeurol 2011;14:257-61
Van De Vijver DA, Walley T, Petri H. Epidemiology of restless legs syndrome as diagnosed in UK primary care. Sleep Med 2004; 5:435-40.
Zucconi M, Ferini-Strambi L. Epidemiology and clinical fndings of restless legs syndrome. Sleep Med 2004; 5:293-9.
Högl B, Kiechl S, Willeit J, Saletu M, Frauscher B, Seppi K, et al. Restless legs syndrome: a community-based study
of prevalence, severity, and risk factors. Neurology. 2005;64:1920-4
Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J. Restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. International Restless Legs Syndrome Study Group. Validation of the International Restless Legs Syndrome Study Group rating scale for restless legs syndrome. Sleep Med 2003;4:121-131
Rangarajan S, Rangarajan S, D'Souza GA. Restless legs syndrome in an Indian urban population. Sleep Med 2007;9:88-93.
Godau J, Klose U, Di Santo A, Schweitzer K, Berg D. Multiregional brain iron deficiency in restless legs syndrome. Mov Disord 2008;23:1184–7
Lozeva-Thomas V. Serotonin brain circuits with a focus on hepatic encephalopathy. Metab Brain Dis 2004;19: 413-20.
Rovira A, Cordoba J, Raguer N, Alonso J. Magnetic Resonance imaging measurement of brain edema in patients with liver disease: resolution after transplantation. Curr Opin Neurol 2002;15:731-37.
Jalan R, Seer JP, Taylor-Robinson SD. Review article: pathogenesis and treatment of chronic hepatic encephalopathy. Aliment Pharmoacol Ther 1996; 10: 681-697.
De Mello MT, Lauro FA, Silva AC, Tufik S. Incidence of periodic leg movements and of the restless legs syndrome during sleep following acute physical activity in spinal cord injury subjects. Spinal Cord 1996;34:294-6
Lidove O, Cacoub P, Maisonobe T, Servan J, Thibault V, Piette JC, et al. Hepatitis C virus infection with peripheral neuropathy is not always associated with cryoglobulinemia. Ann Rheum Dis 2001; 60:290-292.
- Abstract Viewed: 244 times
- PDF Downloaded: 116 times