The evaluation of interleukin-8 chemokine in chronic and acute Toxoplasma gondii infection
Gastroenterology and Hepatology from Bed to Bench,
Vol. 4 No. 1 (2011),
29 December 2010
Aim: We investigated whether the level of IL8 was different in patients with chronic and acute Toxoplasma gondii infection during the pregnancy compared with control group.
Background: It is well established that T.gondii infection induces a strong cell-mediated immune response.
Patients and methods: ELISA was used to determine the level of IL8 in sera of 568 pregnant women. Patients were divided into three groups according to a T.gondii serology. The first group included 202 women with positive IgG titres, the second group was 66 women with IgM and negative IgG T.gondii serology; and the third group comprised the sera of 300 healthy pregnant women with negative T.gondii serology and served as controls.
Results: The level of IL8 in group I was within normal range similar to control group. However, the level of IL8 was increased in those pregnant patients with positive IgM T.gondii serology.
Conclusion: The serum levels of pro-inflammatory cytokines such as IL8 seem to be increased in patients with serological evidence of acute T.gondii infection.
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