Biochemical Pathway Analysis of Gastric Atrophy
Gastroenterology and Hepatology from Bed to Bench,
18 April 2018
Aim: Pathway analysis of gastric atrophy to find new molecular prospective of disease.
Background: Gastric atrophy as a process which is accompanied with “loss of glans” in stomach can be considered as a risk factor of
gastric cancer. Here, the correlated biochemical pathways to the disorder have been analyzed via protein-protein interaction (PPI)
Methods: The genes related to gastric atrophy were retrieved by STRING database and organized in a network by Cytoscape. Three
significant clusters were determined by ClusterONE plug-in of Cytoscape. The elements of cluster-2 which contained all central nodes
of the network were enriched by ClueGO and the biochemical pathways discussed in details.
Results: The number of seven central nodes (which are included in cluster-2); INS, TP53, IL6, TNF, SRC, MYC, and IL8 were
identified. The biochemical pathways related to the elements of cluster-2 were determined and clustered in nine groups. The pathways
were discussed in details.
Conclusion: Pathway analysis indicates that the introduced central genes of the network can be considered as biomarkers of gastric
Keywords: Gastric atrophy, Network analysis, Gene, Biochemical pathway, Central node.
(Please cite as: Rezaei Tavirani M, Rezaei Tavirani S, Tajik Rostami F. Biochemical pathway analysis of gastric
atrophy. Gastroenterol Hepatol Bed Bench 2018;11(2):118-124).
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