Common and differential genetically pathways between ulcerative colitis and colon adenocarcinoma
Gastroenterology and Hepatology from Bed to Bench,
Vol. 10 No. Supplement 1 (2017),
26 December 2017
,
Page S93-101
https://doi.org/10.22037/ghfbb.v0i0.1266
Abstract
Aim: In the present study, genes of Ulcerative Colitis and Colon Adenocarcinoma (COAC) were extracted by string App in Cytoscape software version 3.5.1. Then protein- protein interaction (PPI) networks analyzed.
Background: One of the most common chronic digestive problems is ulcerative colitis (UC) especially in developing countries. Prevalence of the disease is reported about 7.6 to 245 cases per 100,000 per year. UC can lead to colon cancer that is the third malignancy related death in the world. So awareness of the future of the patient with UC and the possibility of colon cancer is a very helpful approach.
Methods: The analysis was based on centralities values. The goal is determining common gene pathways and differential gene pathways of the two diseases.
Results: Results showed there are 11 and 29 central genes related to COAC and UC respectively. At least five common key genes between the two diseases were introduced. The number of 26 terms related to the common key genes were determined and clustered in seven clusters.
Conclusion: ALB, AKT1, TP53, SRC and MYC are the common genes that play crucial roles in the related biological processes of UC and COAC. Besides introducing the common genes the differentiate genes related to the two diseases were proposed.
- Ulcerative colitis
- Colon adenocarcinoma
- PPI network
- Cytoscape
- Gene Ontology
How to Cite
References
Anderson, C. A., et al. (2009). "Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship." Gastroenterology 136(2): 523-529. e523.
Bishehsari, F., et al. (2014). "Epidemiological transition of colorectal cancer in developing countries: environmental factors, molecular pathways, and opportunities for prevention." World journal of gastroenterology: WJG 20(20): 6055.
Chen, W. S., et al. (2001). "Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene." Genes & development 15(17): 2203-2208.
Chng, W., et al. (2007). "Clinical significance of TP53 mutation in myeloma." Leukemia 21(3): 582-585.
Choi, P. M., et al. (1993). "Colonoscopic surveillance reduces mortality from colorectal cancer in ulcerative colitis." Gastroenterology 105(2): 418-424.
Colitis–Pathophysiology, U. (2003). "Inflammatory bowel disease part I: ulcerative colitis–pathophysiology and conventional and alternative treatment options." Alternative medicine review 8(3): 247-283.
Eaden, J., et al. (2000). "Colorectal cancer prevention in ulcerative colitis: a case-control study." Alimentary Pharmacology and Therapeutics 14(2): 145-154.
Ericson, K., et al. (2010). "Genetic inactivation of AKT1, AKT2, and PDPK1 in human colorectal cancer cells clarifies their roles in tumor growth regulation." Proceedings of the National Academy of Sciences 107(6): 2598-2603.
Fondevila, C., et al. (2004). "p53 and VEGF expression are independent predictors of tumour recurrence and survival following curative resection of gastric cancer." British journal of cancer 90(1): 206-215.
Frame, M. C. (2002). "Src in cancer: deregulation and consequences for cell behaviour." Biochimica et Biophysica Acta (BBA)-Reviews on Cancer 1602(2): 114-130.
Furstoss, O., et al. (2002). "c‐Abl is an effector of Src for growth factor‐induced c‐myc expression and DNA synthesis." The EMBO journal 21(4): 514-524.
Jokerst, J. V., et al. (2009). "Nano-bio-chips for high performance multiplexed protein detection: determinations of cancer biomarkers in serum and saliva using quantum dot bioconjugate labels." Biosensors and Bioelectronics 24(12): 3622-3629.
Karbalaei, R., et al. (2017). "A systems biology analysis protein-protein interaction of NASH and IBD based on comprehensive gene information." Gastroenterology and Hepatology from bed to bench 10(3): 194.
Keerthikumar, S. and S. Mathivanan (2017). "Proteomic Data Storage and Sharing." Proteome Bioinformatics: 5-15.
Khayer, N., et al. (2017). "Oral squamous cell cancer protein-protein interaction network interpretation in comparison to esophageal adenocarcinoma." Gastroenterology and Hepatology from bed to bench 10(2): 118.
KIMUYU, P. (2016). "Chronic Inflammation as a Risk Factor for Colon Cancer?".
Kluck, R. M., et al. (1997). "The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis." Science 275(5303): 1132-1136.
Langan, R. C., et al. (2007). "Ulcerative colitis: diagnosis and treatment." American family physician 76(9).
Ławicki, S., et al. (2013). "The plasma concentration of VEGF, HE4 and CA125 as a new biomarkers panel in different stages and sub-types of epithelial ovarian tumors." Journal of ovarian research 6(1): 45.
Lichtiger, S., et al. (1994). "Cyclosporine in severe ulcerative colitis refractory to steroid therapy." New England Journal of Medicine 330(26): 1841-1845.
Maghvan, P. V., et al. (2017). "Network analysis of common genes related to esophageal, gastric, and colon cancers." Gastroenterology and Hepatology from bed to bench.
McGovern, D. P., et al. (2010). "Genome-wide association identifies multiple ulcerative colitis susceptibility loci." Nature genetics 42(4): 332-337.
Meijerink, J., et al. (2001). "A novel method to compensate for different amplification efficiencies between patient DNA samples in quantitative real-time PCR." The Journal of Molecular Diagnostics 3(2): 55-61.
Mertz, J. A., et al. (2011). "Targeting MYC dependence in cancer by inhibiting BET bromodomains." Proceedings of the National Academy of Sciences 108(40): 16669-16674.
Metwally, I. H., et al. (2017). "Epidemiology and survival of colon cancer among Egyptians: a retrospective study." Journal of Coloproctology.
Petitjean, A., et al. (2007). "TP53 mutations in human cancers: functional selection and impact on cancer prognosis and outcomes." Oncogene 26(15): 2157-2165.
Prajapati, K. D., et al. (2010). "Upregulation of albumin expression in focal ischemic rat brain." Brain research 1327: 118-124.
Rezaei-Tavirani, M., et al. (2006). "Conformational study of human serum albumin in pre-denaturation temperatures by differential scanning calorimetry, circular dichroism and UV spectroscopy." BMB Reports 39(5): 530-536.
Rezaei-Tavirani, M., et al. (2017). "Duchenne muscular dystrophy (DMD) protein-protein interaction mapping." Iranian Journal of Child Neurology 11(4): 7-14.
Rezaei-Tavirani, M., et al. (2012). "Fluoxetine competes with cortisol for binding to human serum albumin." Iranian journal of pharmaceutical research: IJPR 11(1): 325.
Rubenstein, J. H., et al. (2009). "Cost effectiveness of ulcerative colitis surveillance in the setting of 5-aminosalicylates." The American journal of gastroenterology 104(9): 2222-2232.
Rutgeerts, P., et al. (2005). "Infliximab for induction and maintenance therapy for ulcerative colitis." New England Journal of Medicine 353(23): 2462-2476.
Safari-Alighiarloo, N., et al. (2016). "Network-based analysis of differentially expressed genes in cerebrospinal fluid (CSF) and blood reveals new candidate genes for multiple sclerosis." PeerJ 4: e2775.
Safari‐Alighiarloo, N., et al. (2017). "Identification of new key genes for type 1 diabetes through construction and analysis of protein–protein interaction networks based on blood and pancreatic islet transcriptomes." Journal of diabetes 9(8): 764-777.
Schwab, S. G., et al. (2005). "Further evidence for association of variants in the AKT1 gene with schizophrenia in a sample of European sib-pair families." Biological psychiatry 58(6): 446-450.
Siegel, R. L., et al. (2015). "Cancer statistics, 2015." CA: a cancer journal for clinicians 65(1): 5-29.
Tsutsumi, T., et al. (1994). "Reciprocal regulation of α-fetoprotein and albumin gene expression by butyrate in human hepatoma cells." Gastroenterology 107(2): 499-504.
Wang, B., et al. (2017). "The risk and survival outcome of subsequent primary colorectal cancer after the first primary colorectal cancer: cases from 1973 to 2012." BMC cancer 17(1): 783.
Winawer, S., et al. (2003). "Colorectal cancer screening and surveillance: clinical guidelines and rationale—update based on new evidence." Gastroenterology 124(2): 544-560.
Zamanian-Azodi, M., et al. (2015). "Protein-Protein Interaction Network could reveal the relationship between the breast and colon cancer." Gastroenterology and Hepatology from bed to bench 8(3): 215.
Zamanian–Azodi, M., et al. (2015). "Introducing biomarker panel in esophageal, gastric, and colon cancers; a proteomic approach." Gastroenterology and Hepatology from bed to bench 8(1): 6.
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