Combined Branch Retinal Vein and Artery Occlusion in Toxoplasmosis with Hyperhomocysteinemia, and Mutation of Factor V Leiden
Journal of Ophthalmic and Optometric Sciences,
Vol. 6 No. 2 (2022),
8 November 2023
,
Page 67-73
https://doi.org/10.22037/joos.v6i2.42823
Abstract
Moreover, heterozygosity of a mutation of factor V Leiden; FVL (coagulation factor V gene) was also observed in the case. The patient was diagnosed with branch retinal vein and artery occlusion with hyperhomocysteinemia and mutation of factor V Leiden. The patient was underwent intravitreal injection of bevacizum (IVB), and PRP laser due to severe retinal ischemia and extensive NVD. The patient was treated with sulfamethoxazole (800 mg), trimethoprim (160 mg), and corticosteroid (1-1.5 mg/kg/day). Vitamin B6 (100 mg/daily), acid folic (5 mg daily), and vitamin B12 (112 mg/daily) were also added to the treatment for 8 weeks. After treatment, the assessment of plasma homocysteine showed that the level of homocysteine was normal. This is the first report of combined retinal branch vein and artery occlusion in toxoplasmosis with hyperhomocysteinemia and mutation of factor V Leiden.
- Branch Retinal Vein
- Branch Artery Occlusion
- Hyperhomocysteinemia
- Mutation of Factor V Leiden
- Ocular Toxoplasmosis
- 2023-12-13 (2)
- 2022-04-03 (1)
How to Cite
References
Aggio FB, Novelli FJd, Rosa EL, Nobrega MJ. Combined branch retinal vein and artery occlusion in toxoplasmosis. Arquivos Brasileiros de Oftalmologia. 2016;79:189-91.
Sanaie S, Nematian J, Shoushtarian SMM. Study of electrooculogram (EOG) abnormalities in patient with ocular toxoplasmosis. Medical Science Journal of Islamic Azad Univesity-Tehran Medical Branch. 2014;24(1):33-6.
Park Y-H, Nam H-W. Clinical features and treatment of ocular toxoplasmosis. The Korean journal of parasitology. 2013;51(4):393.
Lee S-E, Hong S-H, Lee S-H, Jeong Y-I, Lim SJ, Kwon OW, et al. Detection of ocular Toxoplasma gondii infection in chronic irregular recurrent uveitis by PCR. The Korean Journal of Parasitology. 2012;50(3):229.
Chiang E, Goldstein DA, Shapiro MJ, Mets MB. Branch retinal artery occlusion caused by toxoplasmosis in an adolescent. Case Reports in Ophthalmology. 2012;3(3):333-8.
Commodaro AG, Belfort RN, Rizzo LV, Muccioli C, Silveira C, Burnier Jr MN, et al. Ocular toxoplasmosis: an update and review of the literature. Memórias do Instituto Oswaldo Cruz. 2009;104:345-50.
Arai H, Sakai T, Okano K, Aoyagi R, Imai A, Takase H, et al. Presumed toxoplasmic central retinal artery occlusion and multifocal retinitis with perivascular sheathing. Clinical Ophthalmology. 2014:789-92.
Dubey J, Lago E, Gennari SM, Su C, Jones J. Toxoplasmosis in humans and animals in Brazil: high prevalence, high burden of disease, and epidemiology. Parasitology. 2012;139(11):1375-424.
Kahloun R, Mbarek S, Khairallah-Ksiaa I, Jelliti B, Yahia SB, Khairallah M. Branch retinal artery occlusion associated with posterior uveitis. Journal of ophthalmic inflammation and infection. 2013;3:1-5.
Abu El-Asrar A, Abdel Gader A, Al-Amro S, Al-Attas O. Hyperhomocysteinemia and retinal vascular occlusive disease. European journal of ophthalmology. 2002;12(6):495-500.
Deyhim M, Razjou F, Maghsudlu M, Abedini M. Correlation between plasma total homocysteine concentration and the risk of thrombosis. Scientific Journal of Iran Blood Transfus Organ. 2008;4(4):259-64.
McRae MP. Betaine supplementation decreases plasma homocysteine in healthy adult participants: a meta-analysis. Journal of chiropractic medicine. 2013;12(1):20-5.
Wüthrich RP, Cicvara-Muzar S, Booy C, Maly FE. Heterozygosity for the factor v leiden (G1691A) mutation predisposes renal transplant recipients to thrombotic complications and graft loss1. Transplantation. 2001;72(3):549-50.
Eldibany MM, Caprini JA. Hyperhomocysteinemia and thrombosis: an overview. Archives of pathology & laboratory medicine. 2007;131(6):872-84.
- Abstract Viewed: 58 times
- pdf Downloaded: 64 times