Neuro-Ophthalmologic Disorders That Mimic Glaucoma: A Review
Journal of Ophthalmic and Optometric Sciences,
Vol. 5 No. 3 (2021),
15 March 2023
,
Page 48-56
https://doi.org/10.22037/joos.v5i3.40467
Abstract
Background: To summarize the neuro-ophthalmologic disorders that mimic glaucoma.
Material and Methods: All studies from PubMed, Scopus, and Google Scholar were found using these keywords: optic atrophy, neuro-ophthalmologic disorders, glaucoma mimicker, glaucoma masquerader, and mimic glaucoma.
Results: The main neuro-ophthalmologic disorders that mimic glaucoma are large physiologic cupping, optic disc cup asymmetry, hereditary optic neuropathy, tilted disc syndrome, morning glory anomaly, superior segmental optic nerve hypoplasia, optic disc coloboma, optic disc pits, optic disc drusen, high myopia, inflammatory conditions (optic neuritis), toxic-nutritional optic neuropathy, nutritional deficiency, toxins, traumatic optic neuropathy, compressive optic neuropathy, periventricular leukomalacia, hydrocephalus, perinatal asphyxia, ischemic optic neuropathy, and radiation optic neuropathy.
Conclusion: Repeated evaluations of visual functions such as visual acuity, visual field, and color vision are necessary for diagnosing glaucoma mimickers. Furthermore, a precise examination of the optic disc and retina is crucial. Notably, it is necessary to consider normal-tension glaucoma as an exclusionary diagnosis.
- Optic Neuropathy
- Glaucoma
- Optic Nerve
How to Cite
References
Greenfield DS, editor Glaucomatous versus nonglaucomatous optic disc cupping: clinical differentiation. Seminars in ophthalmology; 1999: Taylor & Francis.
Zhang Y-X, Huang H-B, Wei S-H. Clinical characteristics of nonglaucomatous optic disc cupping. Experimental and Therapeutic Medicine. 2014;7(4):995-9.
Senthil S, Nakka M, Sachdeva V, Goyal S, Sahoo N, Choudhari N, editors. Glaucoma Mimickers: a major review of causes, diagnostic evaluation, and recommendations. Seminars in Ophthalmology; 2021: Taylor & Francis.
Sihota R, Srinivasan G, Dada T, Gupta V, Ghate D, Sharma A. Is the ISNT rule violated in early primary open-angle glaucoma—a scanning laser tomography study. Eye. 2008;22(6):819-24.
Maupin E, Baudin F, Arnould L, Seydou A, Binquet C, Bron AM, et al. Accuracy of the ISNT rule and its variants for differentiating glaucomatous from normal eyes in a population-based study. British Journal of Ophthalmology. 2020;104(10):1412-7.
Gandhi M, Dubey S. Evaluation of the optic nerve head in glaucoma. Journal of current glaucoma practice. 2013;7(3):106.
Amador-Patarroyo MJ, Pérez-Rueda MA, Tellez CH. Congenital anomalies of the optic nerve. Saudi Journal of Ophthalmology. 2015;29(1):32-8.
Kjer B, Eiberg H, Kjer P, Rosenberg T. Dominant optic atrophy mapped to chromosome 3q region: II. Clinical and epidemiological aspects. Acta Ophthalmologica Scandinavica. 1996;74(1):3-7.
Lee BJ, Traboulsi EI. Update on the morning glory disc anomaly. Ophthalmic genetics. 2008;29(2):47-52.
Rosdahl JA, Asrani S. Glaucoma masqueraders: diagnosis by spectral domain optical coherence tomography. Saudi Journal of Ophthalmology. 2012;26(4):433-40.
Dias DT, Ushida M, Battistella R, Dorairaj S, Prata TS. Neurophthalmological conditions mimicking glaucomatous optic neuropathy: analysis of the most common causes of misdiagnosis. Bmc Ophthalmology. 2017;17(1):1-5.
Rebolleda G, Noval S, Contreras I, Arnalich-Montiel F, Garcia-Perez J, Munoz-Negrete F. Optic disc cupping after optic neuritis evaluated with optic coherence tomography. Eye. 2009;23(4):890-4.
Grzybowski A, Zülsdorff M, Wilhelm H, Tonagel F. Toxic optic neuropathies: an updated review. Acta ophthalmologica. 2015;93(5):402-10.
Sharma P, Sharma R. Toxic optic neuropathy. Indian journal of ophthalmology. 2011;59(2):137.
Karimi S, Arabi A, Ansari I, Shahraki T, Safi S. A systematic literature review on traumatic optic neuropathy. Journal of Ophthalmology. 2021;2021.
Hata M, Miyamoto K, Oishi A, Makiyama Y, Gotoh N, Kimura Y, et al. Comparison of optic disc morphology of optic nerve atrophy between compressive optic neuropathy and glaucomatous optic neuropathy. PLoS One. 2014;9(11):e112403.
Leaney JC, Nguyen V, Miranda E, Barnett Y, Ahmad K, Wong S, et al. Bruch's membrane opening minimum rim width provides objective differentiation between glaucoma and nonglaucomatous optic neuropathies. American Journal of Ophthalmology. 2020;218:164-72.
Choudhari NS, Neog A, Fudnawala V, George R. Cupped disc with normal intraocular pressure: The long road to avoid misdiagnosis. Indian journal of ophthalmology. 2011;59(6):491.
Jacobson L, Hård A, Svensson E, Flodmark O, Hellström A. Optic disc morphology may reveal timing of insult in children with periventricular leucomalacia and/or periventricular haemorrhage. British Journal of Ophthalmology. 2003;87(11):1345-9.
Jacobson L, Hellström A, Flodmark O. Large cups in normal-sized optic discs: a variant of optic nerve hypoplasia in children with periventricular leukomalacia. Archives of Ophthalmology. 1997;115(10):1263-9.
Gourdeau A, Miller NR. Neuroophthalmological Signs of Hydrocephalus. Neurobiology of Cerebrospinal Fluid 2: Springer; 1983. p. 835-49.
Chinta S, Wallang BS, Sachdeva V, Gupta A, Patil-Chhablani P, Kekunnaya R. Etiology and clinical profile of childhood optic nerve atrophy at a tertiary eye care center in South India. Indian Journal of Ophthalmology. 2014;62(10):1003.
Ghate D, Vedanarayanan V, Kamour A, Corbett JJ, Kedar S. Optic nerve morphology as marker for disease severity in cerebral palsy of perinatal origin. Journal of the neurological sciences. 2016;368:25-31.
Zhao Z, Lan Y, Bai S, Shen J, Xiao S, Lv R, et al. Late-onset radiation-induced optic neuropathy after radiotherapy for nasopharyngeal carcinoma. Journal of Clinical Neuroscience. 2013;20(5):702-6.
Levin F. When Glaucomatous Damage Isn't Glaucoma. Many conditions besides glaucoma can produce the appearance of the disease. Review of ophthalmology. 2013;5(5).
Scuderi G, Fragiotta S, Scuderi L, Iodice CM, Perdicchi A. Ganglion cell complex analysis in glaucoma patients: what can it tell us? Eye and brain. 2020;12:33.
Cole J, Mazzarella J. Glaucoma: hone your differential diagnosis. Review of Optometry. 2016;153(4):74-82.
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