Identification of Potential Biomarkers and Treatment Targets in Retinal Detachment Identify the biomarkers and Treatment Targets in Retinal Detachment
Journal of Ophthalmic and Optometric Sciences,
Vol. 5 No. 1 (2021),
19 Mehr 2022
,
Page 24-40
https://doi.org/10.22037/joos.v5i1.38861
Abstract
Background: Retinal detachment (RD), separation of the neurosensory retina away from its underlying layer of support tissue (retinal pigment epithelium), can be a serious eye condition that affects vision and can lead to blindness if not treated. Understanding the mechanism of RD help us to identify new potential pharmacological targets that may help to understand the pathological mechanism of vision loss in RD patients.
Material and Methods: Statistical analysis is more likely to explicit molecular basis of the disease. At first, the gene expression profile downloaded from the GEO database and was analyzed in the samples of patients with RD and control cases. Then STRING online database was used for reconstruction protein-protein interaction network and ultimately the important signaling pathways and key biomarkers involved in RD were assessed by resulting network analysis and extraction of functional modules. So, bioinformatics analyses were used to identify some biomarkers which could be used efficiently in combination with surgery to further improve final outcome.
Result:There is significant evidence that activation of the photo transduction cascade, interferon signaling, immune response and cytokine signaling in immune system are involved pathways which have major role in RD. as well as our finding indicates that up-regulation of HLA-C, HLA-A, HLA –B and HLA –E involved in the inflammatory response and C1QA, C1QB the members of the complement pathway are strictly correlated with RD.
Conclusion: we revealed multiple overlapping genes related disease and may help to understand the pathological mechanism of vision loss in RD patients.
- Retinal Detachment
- Systems Biology
- Biological Networks
How to Cite
References
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