Visual Evoked Potentials Changes among Patients with Chronic Mustard Gas Exposure
Journal of Ophthalmic and Optometric Sciences,
Vol. 2 No. 2 (2018),
3 April 2018
,
Page 6-9
https://doi.org/10.22037/joos.v2i2.29160
Abstract
Purpose: To report the chronic effect of mustard gas exposure on visual pathway measured by visual evoked potentials.
Patients and Methods: The present study included 150 participants in three groups. The case group included 50 patients with chronic mustard gas exposure inflicted on them during the Iran - Iraq war (1980 - 1988). The first control group included fifty veterans of the Iran - Iraq war with no history of exposure to mustard gas and the second control group included 50 age and sex matched participants with no history of involvement in the war. Visual evoked potentials including latency and amplitude of VEP, P100 peak wave were measured in all participants and were compared between groups.
Results: The result of the present study showed significant delay in mean latency of VEP, P100 peak in the case group compared to both control groups, while the difference in amplitude of VEP, P100 peak was not statistically significant.
Conclusion: A significant delay in the latency of VEP, P100 peak among patients with a chronic history of mustard gas exposure was found, which might be due to disturbances in visual pathway caused by mustard gas exposure.
Keywords: Mustard gas; Evoked potentials; Visual; Iran.
How to Cite
References
Haines DD, Fox SC. Acute and Long-Term Impact of Chemical Weapons: Lessons from the Iran-Iraq War. Forensic Sci Rev. 2014;26(2):97-114.
Balali-Mood M, Mousavi Sh, Balali-Mood B. Chronic health effects of sulphur mustard exposure with special reference to Iranian veterans. Emerg Health Threats J. 2008;1:e7.
Kehe K, Thiermann H, Balszuweit F, Eyer F, Steinritz D, Zilker T. Acute effects of sulfur mustard injury--Munich experiences. Toxicology. 2009;263(1):3-8.
Ghabili K, Agutter PS, Ghanei M, Ansarin K, Shoja MM. Mustard gas toxicity: the acute and chronic pathological effects. J Appl Toxicol. 2010;30(7):627-43.
Riazi A, Hafezi R, Babaei M, Naderi M. Possible long term effects of chemical warfare using visual evoked potentials. Iran J Med Sci. 2014;39(5):467-70.
Ghasemi H, Ghazanfari T, Ghassemi-Broumand M, Javadi MA, Babaei M, Soroush MR, et al. Long-term ocular consequences of sulfur mustard in seriously eye-injured war veterans. Cutan Ocul Toxicol. 2009;28(2):71-7.
Balali-Mood M, Hefazi M, Mahmoudi M, Jalali E, Attaran D, Maleki M, et al. Long-term complications of sulphur mustard poisoning in severely intoxicated Iranian veterans. Fundam Clin Pharmacol. 2005;19(6):713-21.
Rowell M, Kehe K, Balszuweit F, Thiermann H. The chronic effects of sulfur mustard exposure. Toxicology. 2009;263(1):9-11.
Javadi MA, Yazdani S, Sajjadi H, Jadidi K, Karimian F, Einollahi B, et al. Chronic and delayed-onset mustard gas keratitis: report of 48 patients and review of literature. Ophthalmology. 2005;112(4):617-25.
Kothari R, Bokariya P, Singh S, Singh R. A Comprehensive Review on Methodologies Employed for Visual Evoked Potentials. Scientifica (Cairo). 2016;2016:9852194.
Doulah A, Shushtarian SM. Probable Toxic Effect of Methotrexate on visual pathway using visual Evoked potential. Indian Journal of Applied Research. 2016;6(2):499-500.
Shahriary A, Asgari A, Hollisaz MT, Fallah-Husseini H, Sahraei H. Long-term effect of a single dose of sulfur mustard on nerve conduction velocity and electromyography pattern in rat hindlimb. Mil Med. 2003;168(10):849-51.
Holisaz MT, Rayegani SM, Hafezy R, Khedmat H, Motamedi MH. Screening for peripheral neuropathy in chemical warfare victims. Int J Rehabil Res. 2007;30(1):71-4.
- Abstract Viewed: 134 times
- PDF Downloaded: 116 times
