Investigation of the effect of probiotic yogurt and fenugreek on allergic asthma
Archives of Medical Laboratory Sciences,
Vol. 5 No. 2 (2019),
20 March 2019
,
Page 15-21
https://doi.org/10.22037/amls.v5i2.30388
Abstract
Background: Asthma as the variable degrees of airway obstruction is reversible and allergic asthma is a common form of asthma. Yogurt is coagulated milk and fenugreek as a plant is used in traditional medicine. Oral administration of yogurt (as food) can provide probiotic agents that have the main effects on immune responses. In this study, the effect of yogurt and fenugreek on asthma was studied. Materials and Methods: After producing of asthma model in BALB/c mice in 4 groups, groups were treated with yogurt, yogurt-probiotics, and yogurt-fenugreek. At least, total IgE in serum, IL-4, 5, 13 in BAL (Broncho-Alveolar lavage) fluid was measured. Histopathological sections were prepared and eosinophilic infiltration and mucus-secreting were investigated. Results: Eosinophilic infiltration and mucus hyper-secretion were decreased in treated groups. Total IgE in serum was decreased in asthma-yogurt-probiotic and asthma-yogurt-fenugreek groups in comparison with asthmatic and asthma-yogurt groups. The amount of IL-4 in BAL of the asthma-yogurt-fenugreek group was decreased. The amount of IL-5 in BAL of the asthma-yogurt-probiotic and asthma-yogurt-fenugreek groups was decreased. The amount of IL-13 was decreased significantly in three treated groups. Conclusion: This study showed that yogurt with fenugreek and probiotic has a strong effect on suppression of progression of airway inflammation and asthma pathophysiology.
- Herbal Medicine
- Probiotic
- Allergy
- food
- Cow’s milk yogurt
How to Cite
References
Masoli M, Fabian D, Holt S, Beasley R, Program GIfA. The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy. 2004; 59(5):469-78.
Athari SS, Pourpak Z, Folkerts G, Garssen J, Moin M, Adcock IM, et al. Conjugated Alpha-Alumina nanoparticle with vasoactive intestinal peptide as a Nano-drug in treatment of allergic asthma in mice. European Journal of Pharmacology. 2016; 791:811-20.
Athari SS, Athari SM. The importance of eosinophil, platelet and dendritic cell in asthma. Asian Pacific Journal of Tropical Disease. 2014; 4:S41-S7.
Mould AW, Ramsay AJ, Matthaei KI, Young IG, Rothenberg ME, Foster PS. The effect of IL-5 and eotaxin expression in the lung on eosinophil trafficking and degranulation and the induction of bronchial hyperreactivity. The Journal of Immunology. 2000; 164(4):2142-50.
Trachoo N. Yogurt: The fermented milk. Songklanakarin J Sci Technol. 2002; 24(4):727-37.
Kurmann JA. Fermented fresh milk products and their cultures: Technical Dairy Publishing House (diff.); 1978.
Rasic JL, Kurmann JA. Yoghurt. Scientific grounds, technology, manufacture and preparations. Yoghurt Scientific grounds, technology, manufacture and preparations. 1978.
Ellis A. Immunity to bacteria in fish. Fish & shellfish immunology. 1999; 9(4):291-308.
Vientós-Plotts AI, Ericsson AC, Rindt H, Reinero CR. Oral probiotics alter healthy feline respiratory microbiota. Frontiers in microbiology. 2017; 8:1287.
Fleming T, Deutsch M, Murray L. PDR for Herbal Medicines. Montvale, NJ: Medical Economics Co. Inc Fleming PDR for Herbal Medicines. 2000.
Azam Khan M, Azam E. Chest diseases chapter. vol. 2. Tehran: The Institute for Medical History Sciences. 2004:130-3.
Thirunavukkarasu V, Anuradha C, Viswanathan P. Protective effect of fenugreek (Trigonella foenum graecum) seeds in experimental ethanol toxicity. Phytotherapy Research. 2003; 17(7):737-43.
Murugesan M, Revathi R, Manju V. Cardioprotective effect of fenugreek on isoproterenol-induced myocardial infarction in rats. Indian journal of pharmacology. 2011; 43(5):516.
Blaeser F, Bryce PJ, Ho N, Raman V, Dedeoglu F, Donaldson DD, et al. Targeted inactivation of the IL-4 receptor α chain I4R motif promotes allergic airway inflammation. The Journal of experimental medicine. 2003; 198(8):1189-200.
Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, et al. Interleukin-13: central mediator of allergic asthma. Science. 1998; 282(5397):2258-61.
Tanaka H, Kawada N, Yamada T, Kawada K, Takatsu K, Nagai H. Allergen-induced airway inflammation and bronchial responsiveness in interleukin-5 receptor alpha chain-deficient mice. Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology. 2000; 30(6):874-81.
Renz H, Enssle K, Lauffer L, Kurrle R, Gelfand EW. Inhibition of allergen-induced IgE and IgG1 production by soluble IL-4 receptor. International archives of allergy and immunology. 1995; 106(1):46-54.
Athari SM, Nasab EM, Athari SS. Study effect of Ocimum basilicum seeds on mucus production and cytokine gene expression in allergic asthma mice model. Revue Française d'Allergologie. 2018; 58(7):489-93.
Puri P, Mahapatra S, Bijlani R, Prasad H, Nath I. Feed efficiency and splenic lymphocyte proliferation response in yogurt-and milk-fed mice. International journal of food sciences and nutrition. 1994; 45(4):231-5.
De Simone C, Vesely R, Bianchi Salvadori B, Jirillo E. The role of probiotics in modulation of the immune system in man and in animals. International Journal of Immunotherapy. 1993;9(1):23-8.
Puri P, Rattan A, Bijlani R, Mahapatra S, Nath I. Splenic and intestinal lymphocyte proliferation response in mice fed milk or yogurt and challenged with Salmonella typhimurium. International journal of food sciences and nutrition. 1996; 47(5):391-8.
Takahashi T, Oka T, Iwana H, Kuwata T, Yamamoto Y. Immune response of mice to orally administered lactic acid bacteria. Bioscience, biotechnology, and biochemistry. 1993; 57(9):1557-60.
Dini M. Scientific name of medicinal plants used in traditional medicine. Forest and Rangeland Research Institute Publication, Iran. 2006:299-300.
Emtiazy M, Oveidzadeh L, Habibi M, Molaeipour L, Talei D, Parvin M, et al. Investigating the effectiveness of the Trigonella foenum-graecum L.(fenugreek) seeds in mild asthma: A randomized controlled trial. Allergy, Asthma & Clinical Immunology. 2018; 14(1):19.
Razi M. Al-Havi (the large comprehensive). Beirut: Dare Ehia Attorath Al Arabi. 2001.
Kaviarasan S, Naik G, Gangabhagirathi R, Anuradha C, Priyadarsini K. In vitro studies on antiradical and antioxidant activities of fenugreek (Trigonella foenum graecum) seeds. Food chemistry. 2007; 103(1):31-7.
Мokrozub VV, Lazarenko LM, Sichel LM, Babenko LP, Lytvyn PM, Demchenko OM, et al. The role of beneficial bacteria wall elasticity in regulating innate immune response. EPMA Journal. 2015; 6(1):13.
Pinto MGV, Gómez MR, Seifert S, Watzl B, Holzapfel WH, Franz CM. Lactobacilli stimulate the innate immune response and modulate the TLR expression of HT29 intestinal epithelial cells in vitro. International journal of food microbiology. 2009; 133(1-2):86-93.
Del Giudice MM, De Luca M. The role of probiotics in the clinical management of food allergy and atopic dermatitis. Journal of clinical gastroenterology. 2004; 38:S84-S5.
SS A. Immune response shifting of asthma in aging. Middle-East Journal of Scientific Research. 2013; 13:489-98.
Jeffery P, Zhu J, editors. Mucin-producing elements and inflammatory cells. Novartis Found Symp; 2002: Wiley Online Library.
Athari S, Babaloo Z, Tehrani AA, Naderi MM, Aghamohammadi N, Khoshbakht R, et al. Anti-inflammatory effects of silymarin against damages caused by UV irradiation. Global Veterinaria. 2012; 9(2):149-53.
Taghavi M, Khosravi A, Mortaz E, Nikaein D, Athari SS. Role of pathogen-associated molecular patterns (PAMPS) in immune responses to fungal infections. European journal of pharmacology. 2017; 808:8-13.
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