Advances in Nursing & Midwifery

Vol. 24 No. 85 (2015)

Relationship between maternal serum C - reactive protein

Advances in Nursing & Midwifery, Vol. 24 No. 85 (2015), 2 Tir 2015 , Page 31-38
https://doi.org/10.22037/anm.v24i85.8111

Abstract

Abstract 

Abstract Background:

 It is hypothesized that GDM may be a systemic inflammation mediated by cytokine.

This case-control study was designed to investigate correlation between C-reactive protein (CRP) and

 gestational diabetes mellitus (GDM).

 Method:

 In a case-control study, a convenient sample of 60 pregnant women with GDM (case group) and

120 pregnant women without GDM (control group) who attended to GDM and prenatal clinics and women

 

clinics of Ayatollah Taleghani and Mahdiyeh Hospitals were included. Serum level of CRP measured by

 

qualitative and quantitative methods was compared in two groups. Demographic information and

 

reproductive history were obtained by interview. Both of the group was matched in age, parity, first trimester

 body mass index and DMF index. Data were analyzed by descriptive and analytic statistics.

 Result

 : Demographic characteristics and reproductive histories were similar in two groups. Significantly

different was between two groups in serum level of qualitative CRP (p<0/0005) and serum level of

 quantitative CRP (P<0/0005). CRP was strongly associated wish Glucose Challenge Test (GCT) (p<0/0005).

 Conclusion

 : The results suggest that there is correlation between C-reactive protein and gestational diabetes

mellitus, and inflammation may play an important role in the development of gestational diabetes mellitus and

 CRP can act as the risk predictor of GDM. More studies are needed to verify these results.

 Key words:

 Gestational Diabetes, C - reactive protein, Pregnancy

 

 

Keywords:
  • Gestational Diabetes
  • C - reactive protein
  • Pregnancy

How to Cite

Ahi, zahra, Kariman, norosadat, Zahedi, saleh, & Shakeri, nezhat. (2015). Relationship between maternal serum C - reactive protein. Advances in Nursing & Midwifery, 24(85), 31–38. https://doi.org/10.22037/anm.v24i85.8111

References

Baraban E, McCoy L, Simon P(2008). "Increasing Prevalence of Gestational Diabetes and Pregnancy-Related

Hypertension in Los Angeles County.California, 1991–2003", Centers for Disease Control, 5(3): A77. [on line] .

[PMCID: 2483543].

- Coustan D, Jovanovic L(2013) "Treatment and course gestational diabetes mellitus", UpToDate Marketing

Professional, 85.133.137.136-7CBA809361-14, 2013 . [on line]. www.uptodate.com>

- Cunningham FG et al (2010) William's Obstetrics.23rd edition. New York, twickler, wendel.

- D’Anna R et al(2006) "C-reactive protein as an early predictor of gestational diabetes mellitus". Journal of

Reproductive Medicine. 51(1) :55-8. [on line]. [PMID: 16482778].

- Dasanayake AP et al(2008) ״Periodontal Pathogens and Gestational Diabetes Mellitus ״. Journal of Dental

Reseach. 87 (4) :328-333. [on line]. [PMCID:PMC2561333].

- Dehghan A et al(2007) "Genetic Variation,C-reactive protein levels,and incidence of Diabetes", Diabetes, 56 (3):

–8, doi: 10.2337/db06-0922. [on line]. [PMID:23049543].

- Di Benedetto A et al(2005) "Inflammatory markers in women with a recent history of gestational diabetes

mellitus", J Endocrinol Invest, 28(1):34-8. [on line]. [PMID:15816369].

- Horvath K et al(2010) "Effects of treatment in women with gestational diabetes mellitus: systematic review and

meta-analysis". British Medical Journal, 340: c1395, doi: 10.1136/bmj.c1395. [on line]

http://www.bmj.com/content/340/bmj.c1395>

- Keshavars M et al (2005). "Gestational diabetes in Iran: incidence, risk factors and pregnancy outcomes",

[abstract]. Diabetes Research and Clinical Practice. 69(3):279-286. [on line]. [PMID:16095925].

www.ncbi.nlm.nih.gov/pubmed/16098925>

- Lau DC et al (2005) "Adipokines: molecular links between obesity and atheroslcerosis". American Journal of

Physioloy , Heart and Circulatory Physiology. 288 (5): 2031–2041. [on line]. [PMID:15653761].

www.ncbi.nlm.nih .gov/pubmed/ 15653761>

- Li X, Lu X (2007) "Study on correlation between C-reactive protein and gestational diabetes mellitus ", Journal of

Nanjing Medical University. 21(6) :382-385. [on line] .<http://www.researchgate.net/publication/22912394>

- Lopez-Garcia E et al (2005) "Consumption of trans fatty acids is related to plasma biomarkers of inflammation and

endothelial dysfunction". The Journal of Nutrition. 135 (3) 562–6. [on line]. [PMID:15735094]. < www.ncbi

.nlm.nih.gov /pubmed/15735094

Pakzad p (2004) [Principles and Interpretation of Clinical Serology Experiments]. 11th edition. Tehran. Noore

danesh press (Persian).

- Pepys MB, Hirschfield GM (2003) . "C-reactive protein: a critical update", The Journal of Clinical Investigation .

(12) 1805–12, 2003 Jun. [on line]. [PMID:12803013]. < www.jci.org /articles/view/ 18921>

- Pradhan AD et al(2001). "C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus",

JAMA, 286 (3) : 327–34, 2001 Jul. [on line]. [PMID:11466099]. < www.ncbi .nlm.nih.gov /pubmed/

>

- Qiu CH et al .( 2004 ) "A prospective study of maternal serum C-reactive protein (CRP) concentrations and risk of

gestational diabetes mellitus", Paediatric and Perinatal Epidemiology, 18(5):377-84. [on line].

[PMID:15367325]. < www.ncbi .nlm.nih.gov /pubmed/ 15367325 >

- Retnakaran R et al( 2003) . "C-Reactive Protein and Gestational Diabetes: The Central Role of Maternal Obesity",

The Journal of Clinical Endocrinology & Metabolism. 88(8): 3507-12. [on line]. [PMID:12915627].

www.ncbi .nlm.nih.gov /pubmed/ 12915627>

- Rota S et al (2005) . "C-reactive protein levels in non-obese pregnant women with gestational diabetes". The

Tohoku Journal of Experimental Medicine . 206(4) 341-5. [on line]. [PMID:15997206].

- S. Feig D et al ( 2008). "Risk of development of diabetes mellitus after diagnosis of gestational diabetes .״

Canadian Medical Association. 179(3) 229–234. [on line]. [PMID:18663202].

.gov/pmc/articles/ PMC2474881>

- Sudhindra Mohan B (2006). "C-reactive protein in early months of pregnancy as a screening test for Gestational

diabetes mellitus developing in later mouths of pregnancy", The Journal of Obstetrics and Gynecology of India,

(2):131-133. [on line]. < medind.nic.in/ jaq/t06/i2/jaqt06i2p131.pdf>

- Thompson D, Pepys MB, Wood SP(1999) ״The physiological structure of human C-reactive protein and its

complex with phosphocholine ״ Structure. 7 (2) 169–177. [on line]. [PMID:10368284]. < www.sciencedirect

.com/science/article/pii/ S0969212699800239>

- Wolf M et al (2003). "First-trimester C-Reactive Protein and subsequent gestational diabetes ״. Diabetes Care.

(3):819-24. [on line]. [PMID: 12610043]. < care.diabetesjournals .org/content/26/3/819.full.pdf>

  • Abstract Viewed: 474 times
  • PDF Downloaded: 393 times

Download Statastics

Information

Language