Co-Morbidity of Pituitary Adenoma and Frontal Convexity Meningioma: A Case Report and Review of the Literature
International Clinical Neuroscience Journal,
Vol. 7 No. 3 (2020),
21 Tir 2020
Instruction: The current study reports a woman with pituitary adenoma and frontal convexity meningioma that was detected accidentially. To the best of our knowledge, this case is considered as a rare clinical scenario.
Case presentation: A 37 years old woman suffering from amenorrhea and galactorrhea had her detail investigation showed hyperprolactinemia. The patient was diagnosed with a prolactinoma, and a frontal convexity meningioma was discovered on MRI. The prolactinoma controlled with Bromocriptine therapy, while the meningioma monitored through medical observation. After two months of pharmaceutical medication, her symptoms improved with the decrease in serum prolactin.
Conclusion: Thanks to sophisticated MRI techniques, meningioma and prolactinoma were incidentally detected. It should be noted that co-morbidity of prolactinoma and meningioma is very rare. The mechanism of the association between these two familiar types of intracranial tumors has not yet been clarified, which indicates the need for further studies to offer possible targeted treatment for patients.
Keyword: Meningiomas; Prolactinomas; Pituitary adenomas.
- Pituitary adenomas.
How to Cite
Furtado SV, Venkatesh PK, Ghosal N, Hegde AS. Coexisting intracranial tumors with pituitary adenomas: genetic association or coincidence? J Cancer Res Ther. 2010;6(2):221-3.
Simon M, Boström JP, Hartmann C. Molecular genetics of meningiomas: from basic research to potential clinical applications. Neurosurgery. 2007;60(5):787-98; discussion -98.
Ezzat S, Asa SL, Couldwell WT, Barr CE, Dodge WE, Vance ML, et al. The prevalence of pituitary adenomas: a systematic review. Cancer. 2004;101(3):613-9.
Soto-Pedre E, Newey PJ, Bevan JS, Greig N, Leese GP. The epidemiology of hyperprolactinaemia over 20 years in the Tayside region of Scotland: the Prolactin Epidemiology, Audit and Research Study (PROLEARS). Clinical endocrinology. 2017;86(1):60-7.
Umansky F, Shoshan Y, Rosenthal G, Fraifeld S, Spektor S. Radiation-induced meningioma. Neurosurgical focus. 2008;24(5):E7.
Abs R, Parizel PM, Willems PJ, Van de Kelft E, Verlooy J, Mahler C, et al. The association of meningioma and pituitary adenoma: report of seven cases and review of the literature. European neurology. 1993;33(6):416-22.
Amirjamshidi A, Mortazavi SA, Shirani M, Saeedinia S, Hanif H. 'Coexisting pituitary adenoma and suprasellar meningioma-a coincidence or causation effect: report of two cases and review of the literature'. Journal of surgical case reports. 2017;2017(5):rjx039.
Zentner J, Gilsbach J. Pituitary adenoma and meningioma in the same patient. Report of three cases. European archives of psychiatry and neurological sciences. 1989;238(3):144-8.
Gorge HH, Poll W, Gers B. [Para- and suprasellar meningioma coincident with a hormonally active intrasellar hypophyseal adenoma--case report]. Zentralblatt fur Neurochirurgie. 1993;54(4):190-6.
Zhu H, Miao Y, Shen Y, Guo J, Xie W, Zhao S, et al. The clinical characteristics and molecular mechanism of pituitary adenoma associated with meningioma. Journal of translational medicine. 2019;17(1):354.
Jimenez-Hakim E, el-Azouzi M, Black PM. The effect of prolactin and bombesin on the growth of meningioma-derived cells in monolayer culture. Journal of neuro-oncology. 1993;16(3):185-90.
Muccioli G, Ghè C, Faccani G, Lanotte M, Forni M, Ciccarelli E. Prolactin receptors in human meningiomas: characterization and biological role. The Journal of endocrinology. 1997;153(3):365-71.
Spallone A. Meningioma as a sequel of radiotherapy for pituitary adenoma. Neurochirurgia. 1982;25(2):68-72.
Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, et al. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. The Journal of clinical endocrinology and metabolism. 2011;96(2):273-88.
Goldbrunner R, Minniti G, Preusser M, Jenkinson MD, Sallabanda K, Houdart E, et al. EANO guidelines for the diagnosis and treatment of meningiomas. The Lancet Oncology. 2016;17(9):e383-91.
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