Purpose: To investigate the geographical incidence, and grade of prostate cancer in Iran during 2008-2010 and evaluate its relationship with ethnicity.
Materials and Methods: Data was extracted from the nationwide Iranian cancer registry system during 2008-2010. Pathologies and grade was extracted from scanned reports of patients’ pathologies by a urologist.
Results: The average 3-year age standardized incidence rate of prostate cancer during the study period was 11.52 per 100000 males. The age standardized incidence rates for Persian, Arab, Turkish and Turkmen, Lor, Kurd and Baluch ethnicities were 13.5, 9.3, 7.9, 7.9, 7.2 and 2.1 per 100000, respectively. Poisson regression analysis revealed a statistically significant difference in incidence of prostate cancer in Baluch ethnicity (P=0.028) and a near significant difference for incidence of prostate cancer in Turk-Turkmen and Kurd ethnicity (P=0.067 and P=0.082) in comparison with Persian ethnicity. The median Gleason score distribution of prostate cancer was not concordant to the age standardized incidence rates. 97% of all pathologies were adenocarcinoma of the prostate followed by malignant carcinoma (1.9%), and transitional cell carcinoma (1.1%).
Conclusion: The incidence of Prostate cancer was different between Baluch and Fars ethnicities in Iran. The lowest ASR of PCa was observed in Baluch ethnicity, however the possibility of underreporting due to less access in Baluch ethnicity cannot be ruled out. The Gleason distribution pattern was not concordant to the incidence distribution of Prostate cancer.
Sadjadi A, Nooraie M, Ghorbani A, et al. The incidence of prostate cancer in Iran: results of a population-based cancer registry. Archives of Iranian medicine. 2007;10:481-5.
Sandblom G, Varenhorst E. Incidence rate and management of prostate carcinoma. Biomedicine & pharmacotherapy. 2001;55:135-43.
Nakata S, Ohtake N, Kubota Y, et al. Incidence of urogenital cancers in Gunma Prefecture, Japan: a 10‐year summary. International journal of urology. 1998;5:364-9.
Rashidvash V. Iranian people: Iranian ethnic groups. International Journal of Humanities and Social Science. 2013;3:216-26.
Moore MA, Eser S, Igisinov N, et al. Cancer epidemiology and control in North-Western and Central Asia - past, present and future. Asian Pac J Cancer Prev. 2010;11 Suppl 2:17-32.
Herget KA, Patel DP, Hanson HA, Sweeney C, Lowrance WT. Recent decline in prostate cancer incidence in the United States, by age, stage, and Gleason score. Cancer medicine. 2016;5:136-41.
Howlader N. SEER cancer statistics review, 1975-2008. http://seer. cancer. gov/csr/1975_2008/. 2011.
Ferlay J, Steliarova-Foucher E, Lortet-Tieulent J, et al. Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012. Eur J Cancer. 2013;49:1374-403.
Center MM, Jemal A, Lortet-Tieulent J, et al. International variation in prostate cancer incidence and mortality rates. Eur Urol. 2012;61:1079-92.
Ahmadi M, Ranjbaran H, Amiri MM, et al. Epidemiologic and socioeconomic status of bladder cancer in Mazandaran Province, northern Iran. Asian Pac J Cancer Prev. 2012;13:5053-6.
Akbari ME, Hosseini SJ, Rezaee A, Hosseini MM, Rezaee I, Sheikhvatan M. Incidence of genitourinary cancers in the Islamic Republic of Iran: a survey in 2005. Asian Pac J Cancer Prev. 2008;9:549-52.
Basiri A, Shakhssalim N, Jalaly NY, Miri HH, Partovipour E, Panahi MH. Difference in the incidences of the most prevalent urologic cancers from 2003 to 2009 in Iran. Asian Pac J Cancer Prev. 2014;15:1459-63.
Pakzad R, Rafiemanesh H, Ghoncheh M, et al. Prostate cancer in Iran: trends in incidence and morphological and epidemiological characteristics. Asian Pacific Journal of Cancer Prevention. 2016;17:839-43.
Bhurgri Y, Kayani N, Pervez S, et al. Incidence and Trends of Prostate Cancer in Karachi South. Asian Pac J Cancer Prev. 2009;10:45-8.
Albasri A, El-Siddig A, Hussainy A, Mahrous M, Alhosaini AA, Alhujaily A. Histopathologic characterization of prostate diseases in Madinah, Saudi Arabia. Asian Pac J Cancer Prev. 2014;15:4175-9.
Arshad H, Ahmad Z. Overview of benign and malignant prostatic disease in Pakistani patients: a clinical and histopathological perspective. Asian Pacific Journal of Cancer Prevention. 2013;14:3005-10.