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Effect of Visceral, Subcutaneous and Retroperitoneal Adipose Tissue on Renal Function After Living Donor Nephrectomy: A Retrospective Analysis of 69 Cases

Murat Ferhat Ferhatoglu, Eray Atli, Alp Gurkan
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Abstract

Purpose: Recent studies reported that the presence of metabolic syndrome is closely correlated with impaired kidney function after living donor nephrectomy. Since the measurement of body mass index cannot differentiate the amount of body adipose tissue from total body weight, body mass index is not a reliable or enough alone parameter for determining metabolic syndrome. In the present study, we investigated the correlation between body adipose tissue and kidney function recovery following living donor nephrectomy procedure.

Materials and Methods: The patients who underwent living kidney donor nephrectomy consequently from July 2016 through December 2017 were enrolled in the study. A preoperative computed tomography scan measured the visceral (VAdT), retroperitoneal (RPAdT), and subcutaneous (SCAdT) adipose tissue volume. Body mass index, adipose tissue measurements were analyzed according to a postoperative estimated glomerular filtration rate (eGFR).

Results: The decrease between preoperative eGFR, and the first day, the first month and the sixth month eGFR after surgery was statistically significant (p = .001; p = .001; p = .001, respectively). The negative correlation between VAdT/SCAdT measurements and changes in eGFR at the first and the sixth postoperative month compared to preoperative eGFR were found to be statistically significant (p = .049; p = .041, respectively). Additionally, RPAdT measurements and changes in eGFR at the first and the sixth postoperative month compared to preoperative eGFR (decreasing as RPAdT value increased) were found to be statistically significant (p = .035; p = .026, respectively).

Conclusion: According to a preoperative computed tomography scan, VAdT, RPAdT, and VAdT-to-SAdT ratio can predict impaired kidney function recovery. Furthermore, RPAdT measurement is a new variable to predict the impaired kidney function after donor nephrectomy at a postoperative six months in living kidney donors. 


Keywords

Adipose tissue; metabolic syndrome; donor; kidney; retroperitoneal; visceral

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DOI: http://dx.doi.org/10.22037/uj.v0i0.5558

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