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Role of chronic inflammation as a predictor of upstaging/upgrading in prostate cancer: Finding a new group eligible for active surveillance

Mohammad Reza Nowroozi, Mohsen Ayati, Erfan Amini, Seyed Majid Aghamiri, Seyed Ali Momeni, Solmaz Ohadian Moghadam, Farzin Valizadeh
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Abstract

Purpose: We aimed to investigate the correlation between presence of inflammation and pathology upgrading/upstaging in patients with prostate cancer. Materials and Methods: A retrospective study accomplished on 315 patients with prostate cancer, eligible for active surveillance except prostate-specific antigen (PSA) level (PSA<30ng/dL), who underwent radical prostatectomy between 2005 and 2015. Patients divided into two groups based on needle biopsy: A; with evidence of inflammation (chronic prostatitis) and B; without inflammation. The frequency of upstaging and upgrading in both groups was compared in different ranges of PSA level (<10, 10-20 and 20-30ng/dL). Upgrading/Upstaging was defined as increase from one prognostic grade group to another. Statistical analyses were performed to investigate the relation between inflammation and upgrading/upstaging. Results: The mean age of the patients was 68.2 years and the mean PSA level was 10.2 ng/ml. Chronic prostatitis was identified in 82 of 315 cases therefore upgrading/upstaging were seen in only three patients (3.7%) while 39 of 194 (16.7%) patients without inflammation had upgrading/upstaging in final pathology (p-value = 0.003). Other variables including the patient's PSA before surgery, PSA density, and the presence of hypoechoic areas in ultrasound had a significant relationship with the incidence of postoperative upgrading/upstaging. Among studied variables, presence of inflammation in biopsies was found to be the most important predictor of upstaging/upgrading (OR: 0.205). Conclusion: Our data demonstrated that patients with concurrent prostatitis and PCa may have a better prognosis even if the PSA level is higher than 10ng/mL.

Keywords

prostate cancer, chronic prostatitis, serum PSA, active surveillance

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DOI: http://dx.doi.org/10.22037/uj.v0i0.5375

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