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An Adrenal Hepatoid Adenocarcinoma with Left Renal Vein Thrombosis Extending into the Inferior Vena Cava

Xiaokai Deng, Yuting Jin, Wenxue Yang, Shuaibin Wang, Haiqi Mu, Kaiyuan Yu, Youhua He
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Abstract

Hepatoid adenocarcinoma (HAC) is an uncommon tumor with morphological resemblance to hepatocellular car­cinoma. HAC of the adrenal glands is extremely rare. Here, we report the case of an 83-year-old man with adrenal HAC who presented with a greatly increased preoperative serum alpha-fetoprotein level (> 24,200 ng/mL). The findings of magnetic resonance imaging and contrast-enhanced abdominal computed tomography revealed a large mass occupying the left adrenal gland region as well as thrombosis of the renal vein extending into the inferior vena cava. Subsequently, the adrenal HAC was treated by surgical resection and targeted sorafenib therapy. How­ever, the patient died 9 months later because of systemic metastasis of the tumor. In conclusion, adrenal HAC with inferior vena cava tumor thrombosis is extremely rare and challenging to diagnose and treat. Pathological and immunohistochemical examination are helpful for diagnosis and surgical excision is the main strategy for treating the tumor.


References

. Metzgeroth G, Strobel P, Baumbusch T, Reiter A and Hastka J: Hepatoid adenocarcinoma - review of the literature illustrated by a rare case originating in the peritoneal cavity. Onkologie 2010; 33(5): 263-269.

. Malya FU, Bozkurt S, Hasbahceci M, Cipe G, Ahmad IC, Gucin Z, et al: A rare tumor in a patient with hepatic hydatic cyst: adrenal hepatoid adenocarcinoma. Case Rep Med 2014; 2014: 824574.

. Kuo PC, Chen SC, Shyr YM, Kuo YJ, Lee RC, Wang SE: Hepatoid carcinoma of the pancreas. World J Surg Oncol 2015; 13: 185.

. Ishikura H, Fukasawa Y, Ogasawara K, Natori T, Tsukada Y, Aizawa M: An AFP-producing gastric carcinoma with features of hepatic differentiation. A case report. Cancer 1985; 56(4): 840-848.

. Lin J, Cao Y, Yu L, Lin L: Non-α-fetoprotein-producing adrenal hepatoid adenocarcinoma: A case report and literature review. Medicine 2018; 97(39): e12336.

. Yoshioka M, Ihara H, Shima H, Mori Y, Ikoma F, Ueno Y, et.al: Adrenal hepatoid carcinoma producing alpha-fetoprotein: a case report. Hinyokika Kiyo 1994; 40(5): 411-414.

. Su JS, Chen YT, Wang RC, Wu CY, Lee SW, Lee TY: Clinicopathological characteristics in the differential diagnosis of hepatoid adenocarcinoma: a literature review. World J Gastroenterol 2013; 19(3): 321-327.

. Laan DV, Thiels CA, Glasgow A, Wise KB, Thompson GB, Richards ML, et al. Adrenocortical carcinoma with inferior vena cava tumor thrombus. Surgery, 2017; 161: 240-248.

. Cong Q, Li G, Jiang W, Li B, Wang Y, Yao L, et.al: Ectopic choriocarcinoma masquerading as a persisting pregnancy of unknown location: case report and review of the literature. J Clin Oncol 2011; 29(35): e845-848.




DOI: http://dx.doi.org/10.22037/uj.v0i0.5250

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