Association of Severity of Lower Extremity Arterial Disease and Overactive Bladder Syndrome: A Cross Sectional Study
Vol. 17 No. 2 (2020),
16 March 2020
AbstractPurpose: The aim of this study aim is to clarify the relationship between Overactive bladder syndrome (OAB) and severity of lower extremity ischemia by using Fontaine classification system.
Materials and Methods: Patients who were diagnosed with lower extremity arterial disease were enrolled into the study. The Fontaine score of each patient was taken and all patients completed the validated Turkish version of OAB-V8 questionnaire. Body mass index, serum creatinine, blood urea nitrogen, cholesterol and fasting plasma glucose levels were measured. The patients were divided into two groups. Patients with OAB-V8 score above 8 were enrolled into group 1 and patients with OAB-V8 score under 8 were enrolled into group 2.
Results: At the end of study period, 181 patients who met the inclusion criteria were enrolled into the study. Patients with OAB ? 8 score (n= 79) were compared with patients with OAB < 8 score (n= 102). The mean age and the mean BMI were significantly higher in patients with OAB ? 8 (P = .001 and P = .001, respectively). Also, HDL- cholesterol level was found significantly lower in group 1 patients (P= .001). Multivariate regression analysis showed that presence of Fontaine score ? class 2b, age ? 60 years, BMI ? 30 kg/m2 , and HDL-cholesterol levels < 60 mg/dL were predictive factors for OAB.
Conclusion: The present study demonstrated that incidence of OAB is higher in patients with severe lower extremity ischemic symptoms, older age, high BMI, and lower HDL-cholesterol level.
Azurı J, Kafri R, Ziv-Baran T, Stav K. Outcomes of different protocols of pelvic floor physical therapy and anti‐cholinergics in women with wet over‐active bladder: A 4‐year follow‐up. Neurourology and urodynamics, 2017, 36.3: 755-8.
Irwin D, Kopp Z, Agatep B et al. Worldwide prevalence estimates of lower urinary tract symptoms, overactive bladder, urinary incontinence and bladder outlet obstruction. BJU Int 2011; 08:1132–8
Herrington W, Lacey B, Sherliker P et al. Epidemiology of atherosclerosis and the potential to reduce the global burden of atherothrombotic disease. Circ Res 2016;118:535–46
Chapple C (2014) Chapter 2: Pathophysiology of neurogenic detrusor overactivity and the symptom complex of “overactive bladder”. Neurourol Urodyn 33(Suppl 3):S6–S13.
Novo S., Coppola G. Milio G. Critical limb ischemia: definition and natural history. Current Drug Targets-Cardiovascular & Hematological Disorders, 2004, 4.3: 219-25.
Tarcan T, Mangir N, Ozgur MO et al. OAB-V8 overactive bladder questionnaire validation study. Üroloji Bülteni 2012; 21:113–6
Montorsi P, Ravagnani PM, Galli S et al (2006) Association between erectile dysfunction and coronary artery disease: matching the right target with the right test in the right patient. Eur Urol 50:721–31
Acquadro C, Kopp Z, Coyne KS, Corcos J, Tubaro A, Choo MS. Translating overactive bladder questionnaires in 14 languages. Urology, 2006, 67, 536-40.
Ozgor F, Yanaral F, Savun M, Ozdemir H, Sarilar O, Binbay M. Comparison of STONE, CROES and Guy’s nephrolithometry scoring systems for predicting stone-free status and complication rates after percutaneous nephrolithotomy in obese patients. Urolithiasis, 2017, 1-7.
Pinggera G, Mitterberger M, Steiner E et al Association of lower urinary tract symptoms and chronic ischaemia of the lower urinary tract in elderly women and men: assessment using colour Doppler ultrasonography. BJU Int 2008, 102:470–4
Kilinc MF, Yasar E, Aydin HI, Yildiz Y, Doluoglu OG. Association between coronary artery disease severity and overactive bladder in geriatric patients. World journal of urology, 2018; 36(1), 35-40.
Richter HE, Creasman JM, Myers DL, Wheeler TL, Burgio KL, Subak LL. Urodynamic characterization of obese women with urinary incontinence undergoing a weight loss program: the Program to Reduce Incontinence by Diet and Exercise (PRIDE) trial. International Urogynecology Journal, 208, 19, 1653-8.
Tolekova AN, Hadzhibozheva PV, Iliev RN et al. Participation of extracellular Ca2+ or ghrelin in peptide-mediated contraction of strips from rat urinary bladder. Regulatory peptides, 2010; 162(1-3), 79-83.
Zhou P, Li B, Liu B, Chen T, Xiao J. Prognostic role of serum total cholesterol and high-density lipoprotein cholesterol in cancer survivors: A systematic review and meta-analysis. 2017 Clinica Chimica Acta.
- Abstract Viewed: 272 times
- pdf/4886 Downloaded: 136 times