We herein report a case of left renal Wilms’ tumor and right renal hamartoma combined with hypospadias and incomplete orchiocatabasis in a 10-month-old boy. In the literature to date, no case has been reported. The preoperative abdominal computerized tomography (CT) scan was suggestive of bilateral nephroblastomas, and clinical diagnosis was bilateral renal tumors with external genitals malformation, a syndrome? Finally, this case was used by B-ultrasonic guided percutaneous biopsy to help determine the nature of bilateral renal tumors. Afterwards, the boy underwent preoperative chemotherapy, surgery ( a left radical nephrectomy and right wedge excision of the renal tumor) and postoperative chemotherapy. After 3 years of follow-up, there was no evidence of tumor recurrence, the renal function was normal, and the boy’s height, weight and intelligence were also within normal range. Owing to no similar cases as a reference, we discussed the preoperative imaging diagnosis, final etiological diagnosis and appropriate treatment of this disease. Long-term follow-up with a sufficient number of cases may be needed to optimize methods of diagnosis and define optimal treatment options for patients with this extremely rare disease.
Riccardi VM, Sujansky E, Smith AC, et al. Chromosomal imbalance in the Aniridia-Wilms’ tumor association: 11p interstitial deletion. Pediatrics. 1978; 61:604-610.
Reddy JK, Schimke RN, Chang CHJ,et al. Beckwith-Wiedemann syndrome. Wilms’ tumor, cardiac hamartoma, persistent visceromegaly and glomeruloneogenesis in a 2-year-old boy. Arch Pathol. 1972;94:523–531.
Neri G, Martini-Neri ME, Katz BE, et al. The Perlman syndrome: familial renal dysplasia with Wilms tumor, fetal gigantism and multiple congenital anomalies. Am J Med Genet. 1984;19(1):195-207.
De Cicco C, Bellomi M, Bartolomei M, et al. Imaging of lung hamartomas by multidetector computed tomography and positron emission tomography. Ann Thorac Surg. 2008;86:1769–72.
Yamashita K, Matsunobe S, Tsuda T, et al. Solitary pulmonary nodule: preliminary study of evaluation with incremental dynamic CT. Radiology. 1995;194:399-405.
Alwaidh MH, Woodhall CR, Catry TH. Mesenchymal hamartoma of the liver: a case report. Pediatr Radiol. 1997;27:247-249.
Cetin M, Demirpolat G, Elmas N, et al. Stromal predominant type mesenchymal hamartoma of liver: CT and MR features. Comput Med Imaging Graph . 2002;26:167-169.
Rohrschneider WK, Weirich A, Rieden K, et al. US, CT and MR imaging characteristics of nephroblastomatosis. Pediatr Radiol. 1998;28:435-443.
Ko EY, Ritchey ML. Current management of Wilms tumor in children. J Pediatr Urol. 2009;5:56-65.