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The role of Vitamin E – Selenium - Folic acid supplementation in improving the sperm parameters after varicocelectomy: a randomized clinical trial

Arash Ardestani Zadeh, Davood Arab, Naim Sadat Kia, Sajjad Heshmati, Seyed Nilofar Amirkhalili



Purpose: In this study, we aimed to evaluate the effects of antioxidants including Vitamin E-Selenium-Folic acid (Vit E -Se- FA) on semen parameters following varicocelectomy (VCT).

Materials and Methods: Sixty from 64 infertile male patients diagnosed with varicocele (VC) and underwent sub-inguinal VCT were included in the study. Following sub-inguinal VCT, the patients were randomized into two groups: 30 receiving Vit E-Se-FA supplementation for six months, and 30 as the control group with no treatment. The post-operative semen parameters of Vit E-Se-FA receiving group were compared with control group at the end of experiment. The sperm count, percentage of motile and abnormal sperms were considered.

Results: There were statistically significant increasing in terms of count (P=.031) and motility (P=.01) of sperm after six months of receiving Vit E-Se-FA supplementation comparing with control group.

Conclusion: In conclusion, Vit E-Se-FA supplementation could improve the sperm parameters (count and motility of sperm) after VCT. Further studies with larger number of samples are needed to make a proper decision on Vit E-Se-FA supplementation after VCT.

DOI: http://dx.doi.org/10.22037/uj.v0i0.4653


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