Bilateral Primary Renal Lymphoma Presented As Homogenous Renal Enlargement And Acute Interstitial Nephritis
Vol. 17 No. 3 (2020),
16 May 2020
AbstractPrimary renal lymphoma(PRL) is an extremely rare form of extranodal lymphoma andexhibitsas single (10-20%), multifocal nodules (60%), renal invasion from contiguous retroperitoneal disease (25-30%), diffuse infiltration (20%) or perirenal involvement (10%) .Here we report a case of bilateral primary renal lymphoma in a 13 year-old boy who presented with homogenous nephromegaly and acute interstitial nephritis(AIN).The renal biopsy revealed primary renal T lymphoblastic lymphoma. Hyper-CVAD regimen was initiated and the renal function had been recovered after the first round of chemotherapy. To our knowledge, there have only been three reports of primary renal T lymphoblastic lymphoma including ours so far. All the three patients were young and showed as AIN and bilateral renal enlargement. We also reviewed 16 cases of PRL presenting with AIN and enlarged kidneys that have been reported since 1997. Although PRL is quite rare, it must be taken into account when making a differential diagnosis of AIN. Renal biopsy is the gold standard and intensive chemotherapy can preserve the renal function.
Sheth S, Ali S, Fishman E. Imaging of renal lymphoma: Patterns of disease with Pathologic correlation. Radiographics.2006;26:1151-68.
Malbrain ML, Lambrecht GL, Daelemans R, Lins RL, Hermans P, Zachée P. Acute renal failure due to bilateral lymphomatous infiltrates. Primary extranodal non Hodgkin’s lymphoma (p-EN-NHL) of the kidneys: does it really exist? Clin Nephrol. 1994;42(3):163-69.
Stallone G, Infante B, Manno C, Campobasso N, Pannarale G, Schena FP. Primary renal lymphoma does exist: case report and review of the literature. J Nephrol. 2000;13:367-72.
Chen X, Hu D, Fang L, Chen Y, Che X, Tao J, et al. Primary renal lymphoma: A case report and literature review. Oncol Lett. 2016;12(5):4001-4008.
Kose F, Sakalli H, Mertsoylu H, Sezer A, Kocer E, Tokmak N, et al. Primary renal lymphoma: report of four cases. Onkologie. 2009;32(4):200-2.
Cortelazzo S, Ferreri A, Hoelzer D, Ponzoni M. Lymphoblastic lymphoma. Crit Rev Oncol Hematol. 2017;113:304-317.
Becker AM, Bowers DC, Margraf LR, Emmons J, Baum M. Primary renal lymphoma presenting with hypertension. Pediatr Blood Cancer. 2007;48(7):711-3.
Kwakernaak AJ, Hazenberg MD, Roelofs JJ, van Noesel CJ, van Oers MH, van Tellingen A. Precursor T-lymphoblastic lymphoma presenting as primary renal lymphoma with acute renal failure. NDT Plus. 2011;4(5):289-91.
James TC, Shaikh H, Escuadro L, Villano JL. Bilateral primary renal lymphoma. Br J Haematol. 2008;143(1):1.
Hu R, Zhang R, Miao M, Zhu K, Yang W, Liu Z. Central nervous system involvement of primary renal lymphoma with diffuse large B-cell type lymphoma. Am J Case Rep. 2013;14:292-4.
Levendoglu-Tugal O, Kroop S, Rozenblit GN, Weiss R. Primary renal lymphoma and hypercalcemia in a child. Leuk Lymphoma. 2002;43(5):1141-6.
Kaya A, Kanbay M, Bayrak O, Eken G, Memis L, Akcay A, Duranay M. Primary renal lymphoma associated with hepatitis C virus infection. Leuk Lymphoma. 2006;47(9):1976-8.
Omer HA, Hussein MR. Primary renal lymphoma. Nephrology (Carlton). 2007;12(3):314-5.
Li SJ, Chen HP, Chen YH, Zhang LH, Tu YM, Liu ZH. Renal involvement in non-Hodgkin lymphoma: proven by renal biopsy. PLoS One. 2014;9(4):e95190.
Hughes DJ, Fitzgerald N, Sran H, Konig M, Moore-Moffatt R, Webb A, et al. Acute kidney injury as a presentation of primary renal diffuse large B-cell lymphoma in HIV. Int J STD AIDS. 2014;25(5):380-2.
de Menezes Neves PD, Machado JR, Dos Reis MA, de Paiva Marques V. Primary renal lymphoma: an uncommon diagnosis for acute kidney failure. Clin Kidney J. 2012;5(5):476-7.
Guilpain P, Delarue R, Matignon M, Noël LH, Knebelmann B, Fakhouri F. Primary Bilateral Diffuse Renal Lymphoma. Am J Hematol. 2006;81(10):804-5.
Ozaltin F, Yalçin B, Orhan D, Sari N, Caglar M, Besbas N, Bakkaloglu A. An unusual cause of acute renal failure: renal lymphoma. Pediatr Nephrol. 2004;19(8):912-4.
O'Riordan E, Reeve R, Houghton JB, O'Donoghue DJ, Waldek S. Primary bilateral T-cell renal lymphoma presenting with sudden loss of renal function. Nephrol Dial Transplant. 2001;16(7):1487-9.
Stallone G, Infante B, Manno C, Campobasso N, Pannarale G, Schena FP. Primary renal lymphoma does exist: case report and review of the literature. J Nephrol. 2000;13(5):367-72.
Sieniawska M, Bialasik D, Jedrzejowski A, Sopylo B, Maldyk J. Bilateral primary renal Burkitt lymphoma in a child presenting with acute renal failure. Nephrol Dial Transplant. 1997;12(7):1490-2.
Neuhauser TS1, Lancaster K, Haws R, Drehner D, Gulley ML, Lichy JH, Taubenberger JK. Rapidly progressive T cell lymphoma presenting as acute renal failure: case report and review of the literature. Pediatr Pathol Lab Med. 1997;17(3):449-60.
Heggermont WA, Verhoef G, Evenepoel P, Sprangers B, Lerut E, Tousseyn T, Claes K.Clinical case report: a rare cause of acute kidney failure - tissue is the issue. Acta Clin Belg. 2017;72(3):201-204.
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