The Association of MYNN and TERC Gene Polymorphisms and Bladder Cancer in a Turkish Population

Fikriye Polat, Meral Yilmaz, Songul Budak Diler

Abstract


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Purpose: Researchers reported that, MYNN rs10936599 polymorphism is in strong or moderate linkage disequilibrium with SNPs within the 3q26.2 chromosomal region where is also includes the TERC gene. In addition, it has been reported that MYNN rs10936599 had a strong cumulative association with bladder cancer risk, and TERC gene suppresses cell growth in bladder cancer cell lines. In literature, there was not any study together evaluated of their effects of MYNN rs10936599 and TERC rs2293607 polymorphisms on BC risk. Therefore, we aimed to determine whether polymorphisms of MYNN rs10936599 and TERC rs2293607 play any role for bladder cancer in a Turkish population in this study.

Materials and Methods: In this case-control study, 70 patients and 150 controls were investigated. Genotyping analysis was performed by polymerase chain reaction, restriction fragment length polymorphism and DNA sequencing techniques.

Results: Genotype distribution among both groups for MYNN rs10936599 SNP was significant different (p = .001); in spite of there was no difference in genotype distribution for TERC rs2293607 SNP. In addition, patients with CT genotype and CT+TT genotype combination of MYNN SNP have a decreased risk for bladder cancer. Two times increased risk ratio on development of bladder cancer was obtained for CC genotype of the SNP (p = .001). Besides, it has been found that genotype combination of GG+AG/CC versus AA/CC genotypes (TERC/MYNN) shown stronger correlation. Even, we obtained that statistically significant relationship of the C-G haplotypes of two polymorphisms on bladder cancer risk (p = .0001).

Conclusion: At the end of the study, we suggested that, there may an association between a combination of MYNN rs10936599 and TERC rs2293607 polymorphisms and development of bladder cancer in Turkish population.


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DOI: http://dx.doi.org/10.22037/uj.v0i0.4083


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