Mesalazine: A Novel Etiology For Drug-Induced Urinary Calculi

Blaise Corbery, Souhil Lebdai, Shahed Borojeni, Pierre Bigot, Abdel-Rahmène Azzouzi, Thibaut Culty



We report the case of a 23-year-old woman treated by mesalazine for ulcerative colitis and who subsequently presented recurrent renal colic due to mesalazine urinary stones. This is the second case described in the literature.
Mesalazine stones are soft, friable and have an orange-beige color. They are not visible on non-contrast computed tomography (CT). Their diagnosis is based on morpho-constitutional analysis and CT-urography. Patients treated
by mesalazine who present renal colic should undergo CT-urography in order to make the diagnosis.

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[No authorlisted]. Vidal 2017: The Dictionary. 93th ed. Issy-les-Moulineaux: VIDAL France; 2017:2114-7.

Watanabe M, Nishino H, Sameshima Y, Ota A, Nakamura S, Hibi T. Randomised clinical trial: evaluation of the efficacy of mesalazine

(mesalamine) suppositories in patients with ulcerative colitis and active rectal inflammation -- a placebo-controlled study. Aliment Pharmacol Ther. 2013;38:264-73.

Klotz U, Maier KE. Pharmacology and pharmacokinetics of 5-aminosalicylic acid. Dig Dis Sci. 1987;32:46S-50S.

Gisbert JP, Gonzalez-Lama Y, Mate J. 5-Aminosalicylates and renal function in inflammatory bowel disease: a systematic review. Inflamm Bowel Dis. 2007;13:629-38.

Sacks A, Davis MK. A curious case of redbrown urine in a child taking mesalamine. J Pediatr Gastroenterol Nutr. 2013;56:e38-9.

Jacobsson H, Eriksen J, Karlen P. Mesalazineinduced renal calculi. Am J Case Rep. 2013;14:551-3.

Daudon M, Traxer O, Lechevallier E, Saussine C. [Epidemiology of urolithiasis]. Prog Urol. 2008;18:802-14.

Hess B. Drug-induced urolithiasis. Curr Opin Urol. 1998;8:331-4.

Daudon M. [Drug-induced urinary calculi in 1999]. Prog Urol. 1999;9:1023-33.

De Koninck AS, Groen LA, Maes H, Verstraete AG, Stove V, Delanghe JR. An Unusual Type of Kidney Stone. Clin Lab. 2016;62:235-9.

Schwartz BF, Schenkman N, Armenakas NA, Stoller ML. Imaging characteristics of indinavir calculi. J Urol. 1999;161:1085-7.

Vasanth P, Parmley M, Torrealba J, Hamdi T. Interstitial Nephritis in a Patient with Inflammatory Bowel Disease. Case Rep Nephrol. 2016;2016:4260365.

Mehta RL, Awdishu L, Davenport A, et al. Phenotype standardization for drug-induced kidney disease. Kidney Int. 2015;88:226-34.


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