Sexual Dysfunction in Premenopausal Women With Obstructive Sleep Apnea

Zahide Yilmaz, Pinar Bekdik Sirinocak, Bekir Voyvoda, Levent Ozcan

Abstract


70

Purpose: Sexual functions in the males with obstructive sleep apnea syndrome (OSAS) have been well investigated in the literature; however sexual functions in the premenopausal women with OSAS have been studied to a lesser extent.
Materials and methods: The study included 22 premenopausal women diagnosed as OSAS by the polysomnographic (PSG) evaluation. The control group included 13 premenopausal women suspected of sleep-related
respiratory disorder, but whose PSG tests were determined to be normal. Both groups were administered Epworth Sleep Scale (ESS), Beck Depression Scale (BDS), and Female Sexual Function Index (FSFI) questionnaire forms. Relations between disease parameters, and the total FSFI score, and scores of the six FSFI parameter were analyzed.
Results: The total FSFI score in the cases with OSAS, was determined to be significantly lower than that of the control subjects (P = .031). Scores of the desire, arousal, and orgasm were determined to be significantly lower in
the patient group, compared to control group (P = .034; P = .048; P = .039). The total FSFI scores, and scores of the desire, arousal, lubrication, orgasm, satisfaction and pain subscales in the cases did not correlate significantly with the apnea-hypopnea index (AHI), Non-Rapid Eye Movement 1 (NREM1)%, NREM2%, NREM3%, REM%, the time spent with saturation O2< 90%, minimum oxygen saturation (%), ESS scores, and BDS scores (all P > .05).
Conclusion: Women with OSAS experience sexual dysfunction when compared with normal population. Clinical evaluation has to include also the evaluation of sexual life in women.

Full Text:

PDF

52

References


Raina R, Pahlajani G, Khan S, Gupta S, Agarwal A, Zippe CD. Female sexual dysfunction: classification, pathophysiology, and management. FertilSteril. 2007; 88, 1273–84.

Kammerer-Doak D, Rogers RG. Female sexual function and dysfunction. ObstetGynecolClin North Am. 2008; 35:169–83.

Addis IB, Van Den Eeden SK, Wassel-Fyr CL, Vittinghoff E, Brown JS, Thom DH. Sexual activity and function in middle aged and older women. Obstet Gynecol. 2006; 107:755–64.

Chedraui P, Perez-Lopez FR, San Miguel G, Avila C. Assessment of sexualityamong middle- aged women using the Female Sexual Function Index. Climacteric. 2009;12:213–21.

Pasquali D, Maiorino MI, Renzullo A, Bellastella G, Accardo G, Esposito D et al. Female sexual dysfunction in women with thyroid disorders. J Endocrinol Invest. 2013 .

Salonia A, Munarriz RM, Naspro R, Nappi RE, Briganti A, Chionna R et al. Women’s sexual dysfunction: a pathophysiological review. BJU Int. 2004; 93: 1156–64.

Imbimbo C, Gentile V, Palmieri A, Longo N, Fusco F, Granata AM et al. Female sexual dysfunction: an update on physiopathology. J Endocrinol Invest. 2003; : 102-104.

Subramanian S, Bopparaju S, Desai A, Wiggins T, Rambaud C, Surani S.Sexual dysfunction in women with obstructive sleep apnea. Sleep Breath. 2010;14:59-62.

Goncalves MA, Guilleminault C, Ramos E, Palha A, PaivaT. Erectil dysfunction, obstructive sleep apnea syndrome and nasal CPAP treatment. Sleep Med. 2005; 6: 333-9.

Oksuz E, Malhan S. Prevalence and risk factors for female sexual dysfunction in Turkish women. J Urol. 2006; 175: 654–658.

Rosen R, Brown, C, Heiman J, Leiblum S, Meston C, Shabsigh R et al. The Female Sexual Function Index (FSFI): Amultidimensional self-report instrument for the assessment of female sexual function. J Sex Marita.lTher. 2000; 26, 191–208.

Michele D,Marleide da Mota G. Obstructive sleep apnea (OSA) and depressive symptoms. Arq. Neuro-Psiquiatr. 2009 67.

Popovic RM, White DP. Upper airway muscle activity in normal women: influence of hormonal status. J Appl Physio.1998;84:1055-62.

Onem K, Erol B, Sanli O, Kadioglu P, Yalin AS, Canik U et al. Is sexual dysfunction in women with obstructive sleep apnea-hypopnea syndrome associated with the severity of the disease? A pilot study. J Sex Med. 2008; 5:2600-9.

Jurado-Gámez B, Fernandez-Marin MC, Gómez-Chaparro JL, Muñoz-Cabrera L, Lopez-Barea J, Perez-Jimenez F, et al.Relationship of oxidative stres and endothelial dusfunction in sleep apnoea. EurRespir J. 2011;37:873-9.

Mayer P, Dematteis M, Pépin JL, Wuyam B, Veale D, Vila Aet al.Peripheral neuropathy in sleep apnea: a tissue marker of the severity of nocturnal desaturation. Am J Cirt Care Med.1999;159: 213-9.

Dziewas R, Schilling M, Engel P, Boentert M, Hor H, OkegwoAet al. Treatment for obstructive sleep apnoea; effect on peripheral nerve function. J NeurolNeurosurgpsychiatry 2007;78:295-7.

Behan M, WenningerJM.Sexs steroidal hormones and respiratory control. RespirPhysiolNeurobiol. 2008; 164:213-21.

Fanfulla F, Malaguti S, Montagna T, Salvini S, Bruschi C, Crotti Pet al. Erectile dysfunction in men with obstructive sleep apnea: an earlysign of nevre involvement. Sleep. 2000; 23:775-80.

Karkoulias K, Perimenis P, Charokopos N, Efremidis G, Sampsonas F, KaparianosAetal. Does CPAP therapy improve erectile dysfunction in patients with obstructive sleep apnea syndrome? Clin Ter. 2007; 158: 515-8.

Koseoğlu N, Koseoğlu H, Itil O, Oztura I, Baklan B, Ikiz AO et al. Sexual function status in women with obstructive sleep apnea syndrome. J SexMed 2007; 4:1352-7.

Stavaras C, Pastaka C, Papala M, Gravas S, Tzortzis V, Melekos M et al. Sexual function in pre-and post-menopausal women with obstructive sleep apnea syndrome. Int J Impot Res. 2012;24:228-233.

Fanfulla F, Malaguti S, Montagna T, Salvini S, Bruschi C, Crotti P, et al. Erectile dysfunction in men with obstructive sleep apnea: an earlysign of nevre involvement. Sleep. 2000;23:775-80.

Reynaert C, Zdanowicz N, Janne P, Jacques D. Depression and sexuality. PsychiatrDanub. 2010; 22(sppl 1): S: 111-3.

Shindel AW, Eisenberg ML, Breyer BN, Sharlip ID, Smith JF. Sexual function and depressive symptomsamong female North American medical students. J Sex Med. 2011;8:391-9.

Harris M, Glozier N, Ratnavadiel R, Grunstein RR. Obstructive sleep apnea and depression. Sleep Med Rev. 2009; 13:437-44.




DOI: http://dx.doi.org/10.22037/uj.v14i6.3891


Creative Commons License 
This work is licensed under a Creative Commons Attribution 3.0 License