Bilateral Keratocystic Odontogenic Tumor Invading Maxillary Sinuses: A Case Report

Hasan Mohajerani, Amir Hosein Pakravan, Seyed Farzad Aghdashi, Golnaz Nahvi, Saeed Reza Motamedian

Abstract


338

Keratocystic odontogenic tumor (KCOT) is an odontogenic tumor which has the highest rate of recurrence. This report describes a rare case of bilateral ciliated epithelium-lined odontogenic keratocyst in the maxilla of a 15-year-old male. Panoramic radiography showed two lytic lesions on both sides of the maxilla associated with impacted third molars. Computerized tomography image revealed the involvement of both maxillary sinuses by the lesion which was destroying both sinuses’ floors and posterior walls. Histopathologically, the keratinized epithelial-lined cyst of OKC was changed to a ciliated columnar hyperchromatic epithelium, suggesting the fusion of both these epithelia rather than a metaplastic transformation. The patient was treated by surgical enucleation of the cyst and was followed for one year. In this case report the biological behaviour of odontogenic keratocysts and its treatment options are discussed.


Keywords


Keratocystic odontogenic tumor; Odontogenic tumor; Paranasal sinuses

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References


Philipsen H. Om keratocyster (kolesteatomer) i kaeberne. Tandlaegebladet. 1956;60(963):3.

Chhaya S, Walsh R, Salama N. Odontogenic keratocyst: an unusual cause of unilateral nasal swelling. ORL. 1995;57(5):286-8.

Rajkumar G, Hemalatha M, Shashikala R, Sonal P. Massive keratocystic odontogenic tumor of mandible: A case report and review of literature. Indian J Dent Res. 2011;22(1):181.

Shear M, Seward GR. Odontogenic Keratocyst (Primordial Cyst). Cysts of the Oral Regions. Oxford, Butterworth-Heinemann; 1992.

Minami M, Kaneda T, Ozawa K, Yamamoto H, Itai Y, Ozawa M, et al. Cystic lesions of the maxillomandibular region: MR imaging distinction of odontogenic keratocysts and ameloblastomas from other cysts. AJR Am J Roentgenol. 1996;166(4):943-9.

Janse van Rensburg L, Nortje C, Thompson I. Correlating imaging and histopathology of an odontogenic keratocyst in the nevoid basal cell carcinoma syndrome. Dentomaxillofac Radiol. 1997;26(3):195-9.

Browne RM, Smith AJ. Pathogenesis of odontogenic cysts. In: Browne RM, editor. Investigative pathology of odontogenic cysts: CRC Press; 1990. p. 88-109.

Prasad ML, Busam KJ, Patel SG, Hoshaw-Woodard S, Shah JP, Huvos AG. Clinicopathologic differences in malignant melanoma arising in oral squamous and sinonasal respiratory mucosa of the upper aerodigestive tract. Arch Pathol Lab Med. 2003;127(8):997-1002.

Brannon RB. The odontogenic keratocyst: a clinicopathologic study of 312 cases. Part I. Clinical features. Oral Surg Oral Med Oral Pathol. 1976;42(1):54-72.

Myoung H, Hong S-P. Odontogenic keratocyst: review of 256 cases for recurrence and clinicopathologic parameters. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001;91(3):328-33.

Welkoborsky H, Reck R, Sorger K. [Keratocysts of the maxilla and zygoma. Case report and review of the literature]. Laryngorhinootologie. 1989;68(8):464-9.

Zhao Y-F, Wei J-X, Wang S-P. Treatment of odontogenic keratocysts: a follow-up of 255 Chinese patients. Oral Surgery, Oral Medicine, Oral Surg Oral Med Oral Pathol. 2002;94(2):151-6.

Ram H, Mohammad S, Husain N, Gupta S, Kumar A. Bilateral odontogenic keratocyst of the mandible. J Maxillofac Oral Surg. 2014;13(3):341-5.

Devi BY, Rakesh N, Nisha VA, Sagar P, Prasad K. Bilateral keratocystic odontogenic tumor of mandible. Indian J Multidisciplin Dent. 2010;1(1):12.

Gupta A, Rai B, Nair MA, Bhut MK. Keratocystic odontogenic tumor with impacted maxillary third molar involving the right maxillary antrum: an unusual case report. Indian J Dent Res. 2011;22(1):157.

Çakur B, Miloglu Ö, Yolcu Ü, Göregen M, Gürsan N. Keratocystic odontogenic tumor invading the right maxillary sinus: a case report. J Oral Science. 2008;50(3):345-9.

Choi YS, Lee HC, Joo M. Odontogenic Keratocyst In The Maxillary Sinus. J Korean Associat Maxillofacial Plastic and Reconstructive Surgeons. 2002;24(1):61-4.

Kinard BE, Chuang S-K, August M, Dodson TB. For treatment of odontogenic keratocysts, is enucleation, when compared to decompression, a less complex management protocol? J Oral and Maxillo Surg. 2015;73(4):641-8.

Pindborg J, Hansen J. Studies on odontogenic cyst epithelium. Acta Histochem. 1963;58(3):283-94.

Barreto D, Gomez R, Bale A, Boson W, De Marco L. PTCH gene mutations in odontogenic keratocysts. J Dent Res. 2000;79(6):1418-22.

Cohen Jr MM. Nevoid basal cell carcinoma syndrome: molecular biology and new hypotheses. Int J Oral & Maxillo Surg. 1999;28(3):216-23.

Knudson AG. Mutation and cancer: statistical study of retinoblastoma. PNAS. 1971;68(4):820-3.

Bale A, Gailani M, Leffell D. The Gorlin syndrome gene: a tumor suppressor active in basal cell carcinogenesis and embryonic development. Proc Natl Acad Sci U S A. 1995;107(2):253.

Lench NJ, Telford EA, High AS, Markham AF, Wicking C, Wainwright BJ. Characterisation of human patched germ line mutations in naevoid basal cell carcinoma syndrome. Hum Genet. 1997;100(5-6):497-502.

Levanat S, Gorlin RJ, Fallet S, Johnson DR, Fantasia JE, Bale AE. A two-hit model for developmental defects in Gorlin syndrome. Nature Genet. 1996;12(1):85-7.

Nawshad A, Savage N, Young W, Smyth I, Wicking C. Allelic losses in chromosome 9q22. 3-31q in odontogenic keratocysts. J Oral Pathol Med. 2000;29:353.

Farndon PA, Del Mastro RG, Kilpatrick M, Evans D. Location of gene for Gorlin syndrome. The Lancet. 1992;339(8793):581-2.

Heikinheimo K, Jee K, Morgan P, Nagy B, Happonen R, Knuutila S. Gene expression profiling of odontogenic keratocyst. J Oral Pathol Med. 2004;33:462.

Muzio LL, Staibano S, Pannone G, Bucci P, Nocini P, Bucci E, et al. Expression of cell cycle and apoptosis-related proteins in sporadic odontogenic keratocysts and odontogenic keratocysts associated with the nevoid basal cell carcinoma syndrome. J Dent Res. 1999;78(7):1345-53.

Ahlfors E, Larsson Å, Sjögren S. The odontogenic keratocyst: a benign cystic tumor? J Oral and Maxill Surg. 1984;42(1):10-9.

MacLeod R, Soames J. Squamous cell carcinoma arising in an odontogenic keratocyst. Br J Oral Maxillofac Surg. 1988;26(1):52-7.

Woolgar JA, Rippin J, Browne R. The odontogenic keratocyst and its occurrence in the nevoid basal cell carcinoma syndrome. Oral Surg Oral Med Oral Pathol. 1987;64(6):727-30.

Yamazaki M, Cheng J, Nomura T, Saito C, Hayashi T, Saku T. Maxillary odontogenic keratocyst with respiratory epithelium: a case report. J Oral Pathol & Med. 2003;32(8):496-8.

Browne R. The odontogenic keratocyst. Histological features and their correlation with clinical behaviour. Brit Dent J. 1971;131:249-59.

Gardner AF. The odontogenic cyst as a potential carcinoma: a clinicopathologic appraisal. J Am Dent Assoc. 1969;78(4):746-55.

Madras J, Lapointe H. Keratocystic odontogenic tumour: reclassification of the odontogenic keratocyst from cyst to tumour. Texas Dent J. 2008;125(5):446.

Okoje-Adesomoju VN, Adisa AO, Gbolahan OO, Olajide MA. Bimaxillary Keratocystic Odontogenic Tumour: A Case of Diagnostic and Therapeutic Difficulty. Case Rep Med. 2014;2014.

Kwon HI, Lim WB, Kim JS, Ko YJ, Kim IA, Yoon SJ, et al. Odontogenic keratocyst associated with an ectopic tooth in the maxillary sinus: a report of two cases and a review of the literature. Korean J Pathol. 2011;45(Suppl 1):S5-S10.




DOI: https://doi.org/10.22037/rrr.v1i2.10515

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